A5100651414- Rheumatoid Arthritis Research and Therapies
- Neurological Disorders and Treatments
- COVID-19 Clinical Research Studies
- Virus-based gene therapy research
- Oral microbiology and periodontitis research
- Autoimmune and Inflammatory Disorders Research
- Diabetic Foot Ulcer Assessment and Management
- Calpain Protease Function and Regulation
- Remote Sensing and Land Use
- Cancer Research and Treatments
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Gut microbiota and health
- Bone and Joint Diseases
- Bone Metabolism and Diseases
- Erythrocyte Function and Pathophysiology
- Inflammatory Bowel Disease
- Neurological Disease Mechanisms and Treatments
- Environmental Quality and Pollution
- Environmental Changes in China
- Air Quality and Health Impacts
- Cerebrovascular and Carotid Artery Diseases
- Neural and Behavioral Psychology Studies
- Platelet Disorders and Treatments
- Apelin-related biomedical research
Nankai University
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Beijing YouAn Hospital
2024
Union Hospital
2013-2024
Huazhong University of Science and Technology
2014-2024
National Institutes for Food and Drug Control
2024
Zhengzhou University
2011-2024
Beijing Tongren Hospital
2023-2024
Capital Medical University
2022-2024
Guangdong University of Technology
2024
Following peripheral nerve injury (PNI), Wallerian degeneration (WD) in the distal stump can generate a microenvironment favorable for regeneration. Brief low-frequency electrical stimulation (ES) is an effective treatment PNI, but mechanism underlying its effect on WD remains unclear. Therefore, we hypothesized that ES could enhance regeneration by accelerating WD. To verify this hypothesis, used rat model of sciatic transection and provided at injured nerve. The was then evaluated after 1,...
Rheumatoid arthritis (RA) is an autoimmune disease that may be associated with gut microbiota via the aryl hydrocarbon receptor (AhR). Human umbilical mesenchymal stem cells (HUMSCs) have therapeutic potential against RA, but underlying mechanism has not been fully elucidated. The purpose of this study was to explore action HUMSCs in rats collagen-induced (CIA).HUMSCs (1 × 106) were transplanted into each rat CIA. tissue localization and effects ankles assessed. immune status expression...
Abstract Background The study of soil organic carbon characteristics and its relationship with environment vegetation types is great significance to the evaluation sink provided by inland salt marshes. This paper reports fractions in 0–50 cm layers at four communities Qinwangchuan marsh. Results (1) content Phragmites australis community (9.60 ± 0.32 g /kg) was found be higher than that Salicornia europae (7.75 0.18 Tamarix ramosissima (4.96 Suaeda corniculata (4.55 0.11 /kg). (2) dissolved...
Neonatal bacterial meningitis is associated with substantial mortality and morbidity worldwide. meningitis-causing Escherichia coli (NMEC) the most common gram-negative bacteria responsible for this disease. However, interactions of NMEC its environment within host are poorly understood. Here, we showed that a low level leucine, niche-specific signal in blood, promotes pathogenicity by enhancing survival replication blood. A leucine downregulates expression NsrP, small RNA (sRNA) identified...
Acoustic roughness is a psychoacoustic metric frequently employed to characterize the discomfort or unpleasant sensations associated with fast fluctuation features of noise. Generally, higher values are thought be increased discomfort. However, contradictory phenomena have also been observed, e.g., recent study [Huang, Lv, Ni, and Jiang, J. Acoust. Soc. Am. 154(4), 1963–1976 (2023)] found that was predominantly influenced by loudness exhibited negative correlation for aircraft cabin To...
In the diabetic state, local rennin-angiotensin system (RAS) is activated in pancreas, and strongly associated with islet dysfunction. The angiotensin-converting enzyme 2 (ACE2)/angiotensin (1-7) [Ang(1-7)]/Mas axis a protective, negative regulator of classical renin-angiotensin system. this study, we assessed role ACE2/Ang(1‑7)/Mas pancreatic β cell survival function. ACE2 knockout wild-type mice were fed high-fat diet for 16 weeks. We then performed terminal deoxynucleotidyl...
Abstract Nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH) are global epidemic public health problems with pathogenesis incompletely understood. Hepatocyte excessive apoptosis is a significant symbol for NAFLD/NASH patients, and therefore anti-apoptosis therapy could be used treatment. Up-regulation of BCL-2 has been found to closely related anti-apoptosis. gene promoter region C-rich sequence, which can form i-motif structure play important role in regulating...
Diabetic cardiomyopathy (DCM), one severe complication in the diabetes, leads to high mortality diabetic patients. However, understanding of molecular mechanisms underlying DCM is far from completion. Herein, we investigated disease-related differences proteomes based on db/db mice and verified protective roles peroxiredoxin-4 (Prdx4) H9c2 cardiomyocytes treated by palmitic acid (PA). Fasting blood glucose (FBG) cardiac function was detected 6-month-old control mice. The hearts were then...
The aim of this study was to evaluate the effects angiotensin-converting enzyme 2 (ACE2) on glucose homeostasis and islet function in mice. Male wildtype (WT) ACE2 knockout (ACE2 KO) mice were divided into chow diet group long-term high-fat (HFD) group. After 16 weeks feeding, animals evaluated by intraperitoneal tolerance test (IPGTT) insulin releasing (IPIRT). pancreas immunohistochemically stained analyze relative content (IRC), vascular endothelial growth factor (VEGF), microvessel...
Objective: Analysis of the relationship between single nucleotide polymorphisms (SNPs) and outcomes methotrexate (MTX) therapy for rheumatoid arthritis (RA) in China. Materials Methods: TYMS 28 bp VNTR (rs34743033), MTHFR [677C>T (rs1801133) 1298A>C (rs1801131)], ATIC 347C>G (rs2372536), MTR A2756G (rs1805087), MTRR 66A>G (rs1801394) enzyme proteins may be related to MTX therapy, according our previous meta-analysis. A total 162 patients with RA were included study. SNPs evaluated using...
Background: FOLFOX treatment is a method used widely to reduce tumor size in low-set rectal cancer, with variable clinical results. agents comprise mixture of oxaliplatin and 5-fluorouracil, the efficacy which might be modulated by gut microbiome humans. This study aimed determine whether bowel microbiota factor that influences treatment. Methods: To investigate role during treatment, we carried out comprehensive metagenomic metabolomic analyses on 62 fecal samples collected from 37 cancer...
Rheumatoid arthritis (RA) is a common autoimmune disease characterized by chronic inflammation and multifactorial etiology. We previously showed that gut microbiota dysbiosis in the rat ileum involved development of collagen-induced (CIA). The distinct gastrointestinal tract (GIT) plays region-specific roles, but information on different roles GIT compartments CIA rats limited. This study aimed to evaluate differences microbial communities certain gut-associated immunologic factors cecum...
Background Changes in the intestinal microenvironment affected bone destruction rheumatoid arthritis (RA), and spleen deficiency (SD) was closely related to microenvironment. In this study, we aimed explore aggravation of SD on collagen-induced (CIA) protection compound Xiong Fu powder (XFP) CIA with (SD-CIA) based Method An SD-CIA rat model established using Rheum officinale Baill. decoction combined then treated XFP. The aggravating action rats efficacy XFP were evaluated AI scores,...