A5100388717- Aquaculture disease management and microbiota
- Rheumatoid Arthritis Research and Therapies
- Immune Cell Function and Interaction
- Natural product bioactivities and synthesis
- Renal Diseases and Glomerulopathies
- Pharmacological Effects of Natural Compounds
- Invertebrate Immune Response Mechanisms
- Insect symbiosis and bacterial influences
- Viral Infectious Diseases and Gene Expression in Insects
- Osteoarthritis Treatment and Mechanisms
- Cancer and Skin Lesions
- Phytochemistry and Bioactive Compounds
- Chronic Kidney Disease and Diabetes
- Toxin Mechanisms and Immunotoxins
- Bone and Dental Protein Studies
- Phytochemistry and Biological Activities
- Metabolomics and Mass Spectrometry Studies
- T-cell and B-cell Immunology
- Chronic Lymphocytic Leukemia Research
- Breast Lesions and Carcinomas
- Renal and Vascular Pathologies
- Genomics, phytochemicals, and oxidative stress
- dental development and anomalies
- Soft tissue tumor case studies
- Bone Metabolism and Diseases
Peking University Cancer Hospital
2025
Peking University
2025
University of Alberta
2024
Guangzhou University
2024
Shenzhen Pingle Orthopedic Hospital
2024
Liaoning University of Traditional Chinese Medicine
2024
Guangzhou University of Chinese Medicine
2020-2024
Guizhou University
2023
Beijing Hospital of Traditional Chinese Medicine
2023
Inner Mongolia Medical University
2023
Background Intratumoral oncolytic herpes simplex virus 2-GM CSF (OH2) injection has shown safety and antitumor efficacy in patients with solid tumors. Here, we examined the of OH2 as a single agent or combination HX008, an NMPA-approved PD-1 inhibitor, locally advanced metastatic sarcoma patients. Methods This multicenter, phase 1/2 trial enrolled injectable lesions, who had failed at least 1 more lines standard treatment. Patients were treated three dose levels (10 6 , 10 7 8 CCID 50 /mL)...
Rheumatoid arthritis (RA) causes serious disability and productivity loss, there is an urgent need for appropriate biomarkers diagnosis, treatment assessment, prognosis evaluation. To identify serum markers of RA, we performed mass spectrometry (MS)-based proteomics, obtained 24 important in normal RA patient samples using a random forest machine learning model 11 protein–protein interaction (PPI) network topological analysis methods. Markers were reanalyzed additional proteomics datasets,...
Yishen Tongbi decoction (YSTB) which is an herbal formula, has been used for the treatment of rheumatoid arthritis (RA) more than ten years with a better curative effect. Methotrexate (MTX) effective anchoring agent to treat arthritis. There were, however, no head-to-head comparative randomized controlled trials comparing traditional Chinese medicine (TCM) MTX, Therefore, we performed this double-blind, double-model, trial efficacy and safety YSTB MTX in active RA 24 weeks. Patients who met...
Transforming growth factor-ß (TGF-ß) signaling plays an important role in regulating crucial biological processes such as cell proliferation, differentiation, apoptosis, and extracellular matrix remodeling. Many of these are also integral part amelogenesis. In order to delineate a precise TGF-ß during amelogenesis, we developed transgenic mouse line that harbors bovine amelogenin promoter-driven Cre recombinase, bred this with receptor II floxed mice generate ameloblast-specific conditional...
Mannan oligosaccharides (MOS) are a type of functional oligosaccharide which have received increased attention because their beneficial effects on fish intestinal health. However, structural integrity is necessary prerequisite for This study focused exploring the protective dietary MOS supplementation grass carp’s (Ctenopharyngodon idella) (including tight junction (TJ) and adherent (AJ)) its related signalling molecule mechanism. A total 540 carp (215.85 ± 0.30 g) were fed six diets...
The aim of this study was to explore the efficacy Compound small peptide Chinese medicine (CSPCM) on cyclophosphamide (CTX) induced immunosuppression in mice. 100 male Kunming mice were divided into 5 groups: group A (control group), B (model C (100 mg/kg.bw CSPCM), D (200 CSPCM) and E (400 CSPCM). At 1-3 days, B, C, intraperitoneally injected with 80 CTX. results showed that compared A, immune organ index, body weight change, RORγ T gene expression, protein CD3+ cell number, Th17 number...
Tick hemolymph bathes internal organs, acts as an exchange medium for nutrients and cellular metabolites, offers protection against pathogens. Hemolymph is abundant in proteins. However, there has been limited integrated protein analysis tick thus far. Moreover, are difficulties differentiating tick-derived proteins from the host source. The aim of this study was to profile tick/host components Haemaphysalis flava. adult engorged H. flava females collected by leg amputation Erinaceus...
Objective: Analysis of the relationship between single nucleotide polymorphisms (SNPs) and outcomes methotrexate (MTX) therapy for rheumatoid arthritis (RA) in China. Materials Methods: TYMS 28 bp VNTR (rs34743033), MTHFR [677C>T (rs1801133) 1298A>C (rs1801131)], ATIC 347C>G (rs2372536), MTR A2756G (rs1805087), MTRR 66A>G (rs1801394) enzyme proteins may be related to MTX therapy, according our previous meta-analysis. A total 162 patients with RA were included study. SNPs evaluated using...
Peripheral T cell lymphopenia is a clinical phenomenon in some patients with dermatomyositis (DM). Patients are more susceptible to life-threatening infections. However, the pathogenesis of remains unclear. In this study, we aimed determine retinoic acid-inducible gene I (RIG-I) expression peripheral lymphocytes and explore correlation between RIG-I DM. The mRNA protein levels were determined 26 treatment-naive DM by q-PCR Western blot. apoptosis was detected flow cytometry. associations...
Abstract BACKGROUND Citrus pulp (CP) is rich in pectin, and studies have shown that pectin possesses antioxidant, anti‐inflammatory, gut microbiota‐regulating properties. However, the application of CP aquafeed limited. In this study, effect dietary inclusion on intestinal health largemouth bass ( Micropterus salmoides ) was investigated. Juveniles similar size (6.95 ± 0.07 g) were fed isonitrogenous isoenergetic diets containing different levels (0%, 3%, 6%, 9%, 12%, or 15%) for 58 days....
Introduction: Rheumatoid arthritis (RA) is a globally challenging and refractory autoimmune disease, constituting serious menace to human health. RA characterized by recurrent pain difficult resolve, necessitating prolonged medication for control. Yishen Tongbi decoction traditional Chinese herbal compound prescribed treating RA. We have completed 3-year RCT study that confirmed the clinical efficacy of Notably, we observed faster remission rate compared MTX week 4 treatment. In our...
Naru-3 is a prescribed formulation based on the theory of Mongolian medicine for treatment rheumatoid arthritis (RA). consists three medicinal agents: Aconitum kusnezoffii Reichb (caowu), Terminalia chebula Retz (hezi), and Piper longum L (biba). These agents are widely distributed in area China have been used to treat rheumatism centuries.Mongolian commonly RA, but its mechanism action unknown.A rat collagen-induced (CIA) model was established investigate Naru-3. Rats were treated with...
Osthole was traditionally used in treatment for various diseases. However, few studies had demonstrated that osthole could suppress bladder cancer cells and its mechanism unclear. Therefore, we performed a research to explore the potential against cancer.Internet web servers SwissTargetPrediction, PharmMapper, SuperPRED, TargetNet were predict targets. GeneCards OMIM database indicate The intersection of two target gene fragments obtain key genes. Protein-protein interaction (PPI) analysis...
Objective To investigate the clinical features of unicentric Castleman's disease(UCD)with paraneoplastic pemphigus(PNP)and bronchiolitis obliterans(BO).Method Data UCD patients with PNP and BO from Peking Union Medical College Hospital were retrospectively analyzed,along literatures review. Results Totally 23 cases(11 males 12 females)were enrolled.The median age was 31 years(13-56 years).The most common pathological type hyaline-vascular variant(91.4%),and tumors located in abdominopelvic...
Two new oleanane triterpenoid saponins, bodiniosides Q (1) and R (2), along with five known niga-ichigoside F1 (3), 3-O-[β-D-glucopyranosyl]-28-O-[α-L-rhamnopyranosyl -(1→2)-β-D-glucopyranosyl] arjunolic acid (4), asiaticoside E (5), sericoside (6), bodinioside (7), were isolated from the aerial parts of Elsholtzia bodinieri. The structures 1 2 characterized by spectroscopic techniques chemical evidence as 3-O-β-D- xylopyranosyl-2α, 23-dihydroxy-olean-12-en-28-oic 28-O-α-L-rhamnopyranosyl-...
Investigation of the n-BuOH extract aerial parts Elsholtzia bodinieri led to isolation two new ursane-type triterpenoid saponins, bodiniosides O (1) and P (2), along with five known rotungenoside (3), 3,28-O-bis-β-d-glucopyranosides 19α-hydroxyarjunolic acid (4), oblonganosides I (5), rotungenic 28-O-α-L-rhamnopyranosyl-(1→2)-β-d-glucopyranoside (6), bodinioside M (7) isolated from species. The structures compounds 1 2 were characterized by spectroscopic data as well hydrolysis GC analysis...