A5030901098- Immune Cell Function and Interaction
- Rheumatoid Arthritis Research and Therapies
- Chronic Lymphocytic Leukemia Research
- Pharmacological Effects of Natural Compounds
- Autophagy in Disease and Therapy
- Cytokine Signaling Pathways and Interactions
- T-cell and B-cell Immunology
- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Atrial Fibrillation Management and Outcomes
- Viral Infections and Vectors
- Systemic Lupus Erythematosus Research
- Toxin Mechanisms and Immunotoxins
- Systemic Sclerosis and Related Diseases
- Poisoning and overdose treatments
- Spinal Hematomas and Complications
- Leptospirosis research and findings
- Monoclonal and Polyclonal Antibodies Research
- Neuropeptides and Animal Physiology
- Diagnosis and treatment of tuberculosis
- Lymphoma Diagnosis and Treatment
- Hepatitis C virus research
- Peptidase Inhibition and Analysis
- IL-33, ST2, and ILC Pathways
Shandong Provincial Hospital
2024
Shandong First Medical University
2024
Guangzhou University of Chinese Medicine
2019-2023
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2019
Gilead Sciences (United States)
2018
Qingdao University
2017
Affiliated Hospital of Qingdao University
2017
Henan Provincial People's Hospital
2016
Zhengzhou University
2016
Rheumatoid arthritis (RA) causes serious disability and productivity loss, there is an urgent need for appropriate biomarkers diagnosis, treatment assessment, prognosis evaluation. To identify serum markers of RA, we performed mass spectrometry (MS)-based proteomics, obtained 24 important in normal RA patient samples using a random forest machine learning model 11 protein–protein interaction (PPI) network topological analysis methods. Markers were reanalyzed additional proteomics datasets,...
Yishen Tongbi decoction (YSTB) which is an herbal formula, has been used for the treatment of rheumatoid arthritis (RA) more than ten years with a better curative effect. Methotrexate (MTX) effective anchoring agent to treat arthritis. There were, however, no head-to-head comparative randomized controlled trials comparing traditional Chinese medicine (TCM) MTX, Therefore, we performed this double-blind, double-model, trial efficacy and safety YSTB MTX in active RA 24 weeks. Patients who met...
Rheumatoid arthritis (RA) is a chronic autoimmune disease. Strong evidence supports that excessive activation of B cells plays critical role in the pathogenesis RA. Fc gamma receptor b (FcγRIIb) cell inhibitory and inhibits BCR (B receptor) signalling part by selectively dephosphorylating CD19 which considered co-receptor for essential activation. Our previous study demonstrated FcγRIIb I232T polymorphism presented strong genetic link to RA may lead cells. Therefore, novel therapeutic...
IL-37 is a cytokine that plays critical protective roles in many metabolic inflammatory diseases, and its therapeutic potential has been confirmed by exogenous administration. However, regulatory mechanisms remain unclear. U937 cells were treated with autophagy-modifying reagents (3-MA, chloroquine, rapamycin) or without LPS stimulation. Thereafter, expression autophagic markers (Beclin1, P62/SQSTM1, LC3) determined. For signal pathways, phosphorylated proteins of NF-κB (p65 IκBα), AP-1...
<h3>Background</h3> Autophagy has been shown as an intrinsic cellular defense mechanism in innate and adaptive immune responses is reported to regulate inflammation during infection [1], Accumulating evidence indicates that autophagy suppresses inflammasome activation [2-5]. IL-37 identified anti-inflammatory factor translocates into the nucleus downregulates other pro-inflammatory cytokines [6]. Nevertheless, whether regulates expression of not elucidated. <h3>Objectives</h3> The purpose...
Objectives: To investigate the clinical value of T-SPOT.TB technology (γ-interferon release assay for tuberculosis (TB) infection in diagnosis TB elderly patients.Methods: One-hundred forty out patients and diagnosed with our hospital from February 2013 to 2014 were classified into a young adult group or an group.Patients both groups underwent peripheral blood tests purified protein derivative test (tuberculin test), results analyzed. Results:The positive rate patient was 90.3%,...
<h3>Background</h3> In addition to gender and ethnicity, modifiable variables like geography, socioeconomic status, health system structure, education, physician expertise may influence outcomes in systemic lupus erythematosus (SLE). <h3>Objectives</h3> To compare characteristics of treatment options for subsets Chinese American patients with SLE elucidate factors that contribute disease activity damage. <h3>Methods</h3> Chart review 77 (Qingdao) 48 Midwestern (Louisville, Kentucky) meeting...
<h3>Background:</h3> Filgotinib (FIL), an oral selective JAK1 inhibitor, has shown good safety and efficacy in two phase 2b studies (background methotrexate (MTX, DARWIN 1) as monotherapy (DARWIN 2)) active rheumatoid arthritis (RA) patients with inadequate response to MTX<sup>1,2</sup>. We conducted a large-scale RNA sequencing study of genes expressed blood samples from these studies. <h3>Objectives:</h3> Identify RA-associated gene transcripts that are altered FIL treatment....
Abstract Background Rheumatoid arthritis (RA) is a common chronic autoimmune disease that seriously affects the quality of life patients because damage to joints. Presently, RA mainly treated with disease-modifying antirheumatic drugs (DMARDs) or biological agents; however, they offer limited efficacy in some patients. Therefore, additional therapeutic strategies need be developed. Yishen Tongbi decoction traditional Chinese medicine formulation widely used treat China. However, currently,...