A5102019967- Phytochemicals and Medicinal Plants
- Medicinal Plants and Neuroprotection
- Essential Oils and Antimicrobial Activity
- Phytochemical Studies and Bioactivities
- Phytochemistry and Bioactive Compounds
- Natural product bioactivities and synthesis
- Andrographolide Research and Applications
- Metabolomics and Mass Spectrometry Studies
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Biological Activities
- Adipose Tissue and Metabolism
- Cholinesterase and Neurodegenerative Diseases
- Diet and metabolism studies
- Berberine and alkaloids research
- Endometriosis Research and Treatment
- Pregnancy and preeclampsia studies
- Gut microbiota and health
- Plant biochemistry and biosynthesis
- Liver Disease Diagnosis and Treatment
- Food Science and Nutritional Studies
- Plant-derived Lignans Synthesis and Bioactivity
- Pharmacological Effects of Medicinal Plants
- Cancer-related Molecular Pathways
- Computational Drug Discovery Methods
- Moringa oleifera research and applications
Heilongjiang University of Chinese Medicine
2016-2025
Innovation Team (China)
2024
Chinese Academy of Sciences
2024
Ministry of Education of the People's Republic of China
2023
Heilongjiang University
2007-2021
Zhengzhou University
2016
Henan Provincial People's Hospital
2016
Harbin Medical University
2015
Second Affiliated Hospital of Harbin Medical University
2015
Abstract Tetrandrine (Tet) bisbenzylisoquinoline alkaloids isolated from Stephania tetrandra and other related species of Menispermaceae. It has been demonstrated to have positive therapeutic effects on cardiovascular disease, hypertension, silicosis, autoimmune diseases. In recent years, some reports shown that Tet anticancer activity in human cancers. To explore the pharmacological mechanism colon cancer its unique advantages as a natural product. present study, analyses cell cycle,...
Bear bile powder is an essential, traditional and valuable Chinese herbal medicine that clears heat, calms the liver, improves eyesight. Early studies have shown bear has lipid-lowering activity, but due to scarcity of natural resources, it yet be used on a large scale. Researchers found tauroursodeoxycholic acid (TUDCA) primary characteristic bioactive substance powder. This study aimed investigate therapeutic effect TUDCA high-fat diet (HFD)-induced hyperlipidemia. A hyperlipidemia model...
Four new withanolides named dmetelins A–D (compounds 1–4), along with the known compound 7α,27-dihydroxy-1-oxo-witha-2,5,24-trienolide (5) were isolated from leaves of Datura metel L. (Solanaceae). Their structures elucidated on basis detailed analysis 1D and 2D NMR mass spectrometry data. All compounds evaluated for their inhibitory effects lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells. Compounds 1, 4 5 showed significant activities, 2 3 moderate activities...
Chemical investigation of the 50% ethanol eluate fraction from a macroporous resin flowers Datura metel L. collected in Jiangsu Province China resulted isolation two new withanolides, baimantuoluoline G (1) and baimantuoluoside H (2). Their structures were elucidated as (12β,6β,22R)-1,10-seco-6,12,27-trihydroxy-26-oxo-witha-3,5,24-trienolide-1-oic acid-ε-lactone (5β,6α,12β,22R)-5,6,12,27-tetra-hydroxy-1,26-dioxo-witha-2,24-dienolide-27-O-β-glucopyranoside (2) on basis extensive spectroscopic...
A new sesquiterpenoid glycoside, consisting of one vetispirane-type, dmetelisproside (1), together with two known megastigmane sesquiterpenoids, citroside (2) and staphylionoside D (3) were isolated from the leaves Datura metel L. The structures determined by analysis their MS NMR data as well comparison literature values. All isolates evaluated for cytotoxicity toward SGC-7901, Hepg2, HeLa, MCF-7, MDA-MB-231 cancer cell lines, anti-inflammatory activity against nitric oxide (NO) in RAW...
Abstract Three new withanolide compounds named baimantuoluoline A ( 1 ), B 2 and C 3 ) the two known withanolides withafastuosin E 4 withametelin 5 were isolated from fraction exhibiting activity for psoriasis in flower of Datura metel L. The three structures determined as (5 α ,6 ,7 ,12 β ,15 ,22 R )‐6,7‐epoxy‐5,12,15‐trihydroxy‐1‐oxowitha‐2,24‐dienolide )‐ 5,6,15,21‐tetrahydroxy‐1‐oxowith‐24‐enolide )‐5,6,12,21‐tetrahydroxy‐27‐methoxy‐1‐oxowitha‐2,24‐dienolide on basis extensive...
Abstract Three new withanolide compounds, named baimantuoluolines D–F, along with three known withanolides and a lignan were isolated from the flower of Datura metel L., parts effective against psoriasis. The structures compounds elucidated as (5 α ,6 β ,12 ,20 R ,22 ,24 ,25 S )‐21,24‐epoxy‐5,6,12‐trihydroxy‐27‐methoxy‐1‐oxowith‐2‐enolide ( 1 ), )‐21,24‐epoxy‐5,6,12,27‐tetrahydroxy‐1‐oxowith‐2‐enolide 2 )‐5,6,12,21‐tetrahydroxy‐1‐oxowith‐24‐enolide( 3 ) on basis physicochemical evidence.
Abstract In search for bioactive compounds from the flower of Datura metel L., three new withanolide glucosides, namely baimantuoluosides A, B, and C ( 1 – 3 , resp.) were isolated. Enzymatic hydrolysis afforded corresponding aglycones 1a, 2a 3a respectively. The structures elucidated as (5 α ,6 ,7 ,12 β ,22 R )‐5,12‐dihydroxy‐1,26‐dioxo‐6,7 : 22,26‐diepoxyergosta‐2,24‐dien‐27‐yl ‐ D ‐glucopyranoside ), 2 )‐5‐hydroxy‐1,26‐dioxo‐6,7 ) on basis chemical physicochemical evidence, are further...
AIM:To investigate whether the Chinese medicine Tong Xie Yao Fang (TXYF) improves dysfunction in an irritable bowel syndrome (IBS) rat model. METHODS:Thirty baby rats for IBS modeling were separated from mother (1 h per day) days 8 to 21, and rectum was expanded by angioplasty 12.Ten normal used as controls.We examined effects of TXYF on defection frequency, colonic transit function smooth muscle contraction, expression 5-hydroxytryptamine (5-HT) substance P (SP) hypothalamus tissues Western...
Daturataturin A (DTA), a withanolide compound in Datura metel L., exhibits excellent anti‐inflammatory and anti‐proliferative activities. Here, we report the study of DTA‐induced proliferation inflammation human immortalized keratinocytes (HaCaTs) associated molecular mechanisms. HaCaTs are model epidermal proliferative state cells. The pharmacodynamics mechanism DTA were studied by western blot, immunofluorescence, apoptosis detection, real‐time quantitative polymerase chain reaction. We...