A5101481894- Traumatic Brain Injury and Neurovascular Disturbances
- Optical Imaging and Spectroscopy Techniques
- Advanced MRI Techniques and Applications
- Electrical and Bioimpedance Tomography
- Systemic Lupus Erythematosus Research
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Cytokine Signaling Pathways and Interactions
- Intracerebral and Subarachnoid Hemorrhage Research
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Neurological Disease Mechanisms and Treatments
- Inflammasome and immune disorders
- Nosocomial Infections in ICU
- Traditional Chinese Medicine Analysis
- Flavonoids in Medical Research
- Traumatic Brain Injury Research
- Polyamine Metabolism and Applications
- Cancer-related molecular mechanisms research
- Antibiotic Use and Resistance
- Radiomics and Machine Learning in Medical Imaging
- Spondyloarthritis Studies and Treatments
- Neuropeptides and Animal Physiology
- Chemical Synthesis and Analysis
- Antibiotics Pharmacokinetics and Efficacy
Huazhong University of Science and Technology
2025
Tongji Hospital
2025
The First Affiliated Hospital, Sun Yat-sen University
2010-2024
The First People's Hospital of Xiaoshan District, Hangzhou
2021-2024
Wenzhou Medical University
2024
Sun Yat-sen University
2010-2024
Sixth Affiliated Hospital of Sun Yat-sen University
2024
Guangzhou University of Chinese Medicine
2022-2023
Hunan Normal University
2020-2023
Hunan Provincial People's Hospital
2020-2023
It is still a clinical challenge to sustain the remission of rheumatoid arthritis (RA); thus, identifying more effective and safer agents for RA treatment remains an urgent demand. We investigated anti-arthritic activity potential mechanism action sodium Danshensu (SDSS), structurally representative water-soluble derivative Danshen, on collagen-induced (CIA) mice. Our results showed that paw edema, synovium hyperplasia, bone destruction, serum levels both IL-1β IL-6 were ameliorated by SDSS...
Dihydroarteannuin (DHA), the primary element of artemisinin extracted from traditional Chinese herb Artemisia annua L., has been used in malaria treatment for a long time. Recently, many studies have indicated that DHA also exhibits potent anti-rheumatoid arthritis (RA) activity. In this study, collagen-induced (CIA) DBA/1J mice and inflammatory model THP-1 cells were established to evaluate modulatory effects on joint destruction explore underlying mechanisms. Our results showed decreased...
As a common secondary disease, edema after traumatic brain injury (TBI) can increase volume, resulting in elevated intracranial pressure (ICP), shift, and cerebral hernia, eventually lead to death. The real-time continuous monitoring of may significantly reduce mortality disability. In this paper, dual-parameter synchronous system based on the reflection transmission characteristics two-port test network was established; 15 rabbits were chosen perform 24-h phase shift (RPS) (TPS)...
Cerebral edema (CE) is a non-specific pathological swelling of the brain secondary to any type neurological injury. The real-time monitoring focal CE mostly found in early stage great significance reduce mortality and disability. Magnetic Induction Phase Shift (MIPS) expected achieve non-invasive continuous CE. However, most existing MIPS sensors are made hard materials which makes it difficult accurately retrieve information. In this article, we designed conformal two-coil structure...
Recently, research on rheumatoid arthritis (RA) has made rapid progress and grown rapidly. It is a challenge to comprehensively understand RA hotspots. The aim of this study was explore the current status trends through bibliometric analysis provide directions for future development.Publications from 2011 2020 were retrieved Web Science Core Collection database (WoSCC). VOSviewer, CiteSpace online platform used analyze publication characteristics, including countries, institutions, journals,...
Background: Ischemic stroke is a highly complex disorder. This study aims to identify novel methylation changes in ischemic stroke. Methods: We carried out an epigenome-wide of using Infinium HumanMethylation 850K array (cases:controls = 4:4). 10 CpG sites 8 candidate genes from gene ontology analytics top-ranked pathway were selected validate BeadChip results 20:20). further qualified the level promoter regions 188:188). Besides, we performed subgroup analysis, dose-response relationship...
Closed cerebral hemorrhage (CCH) is a common symptom in traumatic brain injury (TBI) patients who suffer intracranial with the dura mater remaining intact. The diagnosis of CCH prior to hospitalization and early stage disease can help get earlier treatments that improve outcomes. In this study, noncontact, portable system for TBI-induced detection was constructed measures magnetic induction phase shift (MIPS), which associated mean conductivity caused by ratio between liquid (blood/CSF...
A novel method was developed based on near-field coupling phase shift (NFCPS) to perform non-contact and bedside monitoring of cerebral edema in the intensive care unit (ICU). total 17 subjects were selected conduct real-time NFCPS divided into surgical group, conservative group control group. The data collected at an interval 12 h, until patients left ICU for various reasons, such as being transferred general ward or discharged from hospital. Continuous collection conducted 15 min each time...
Objective Immune checkpoint inhibitor pneumonitis (CIP) is a prevalent form of immunotherapy-induced pulmonary toxicity, ranking among the leading causes mortality associated with immune inhibitors (ICIs). Despite its significance, risk stratification CIP in advanced non-small cell lung cancer (NSCLC) remains uncertain. In this study, we conducted comprehensive analysis, comparing various factors such as histological types, treatment regimens, PD-L1 expression levels, and EGFR/ALK negativity...
Pneumonia is a major complication leading to death after stroke. The risk factors of pneumonia in convalescent patients who have experienced stroke remain poorly defined.
Ceftazidime-avibactam (CAZ-AVI) is a new cephalosporin/β-lactamase inhibitor combination that received clinical approval in China 2019. This study aims to investigate the efficacy and safety of CAZ-AVI treatment Klebsiella pneumoniae (KP) infection hospital, differences among various sites between monotherapy therapy, providing valuable insights for its further application.Patients who used January 2019 April 2023 were identified through hospital information system. Demographic information,...
Abstract In order to protect the environment and public health, microwave irradiation was investigated as a means of reducing nitrosamines level tobacco smoke under mild conditions where energy 1 kW time shorter than 2 min. The microwave‐induced elimination such N ‐nitrosopyrrolidine (NPYR) ‐nitrosodiphenylamine (NDPA) impact presence water salt in medium on reduction assessed detail. existence crucial for NDPA, because rapid movement molecules influence microwaves strongly affects adjacent...
盲速旁瓣可能增加长时间相干积累方法Radon-Fourier变换(RFT)的虚警概率并影响检测性能。为此，该文提出一种基于脉冲重复间隔(PRI)设计的盲速旁瓣抑制方法。利用不同PRI盲速旁瓣位置及速度分辨率的关系，给出了PRI具体设计方法。然后，联合处理两个相邻相参处理间隔(CPI)的RFT输出结果，在不降低RFT积累性能的情况下实现盲速旁瓣(BSSL)的抑制。最后，数值实验结果验证了该文所提方法的有效性。
Advancement in the treatment of glioma has been vacant since temozolomide proved its therapeutic value glioblastoma 2005.To help investigators understand landscape clinical research, we analyzed characteristics and trends globally registered trials past decades.This is a cross-sectional analysis on ClinicalTrials.gov between January 2006 December 2021. Characteristics regarding phase, enrollment number, study design type, funding source, tumor site, pathology, patient status, age population,...
ObjectiveTo explore the value of metagenomic next-generation sequencing (mNGS) and culture in microbial diagnosis patients with acute infection.MethodsWe retrospectively analyzed 206 specimens from 163 who were admitted to emergency department The First Affiliated Hospital Sun Yat-sen University between July 2020, 2021. We evaluated diagnostic efficacy mNGS in-hospital traditional culture.ResultsThe total positive rate was significantly higher than that methods (71.4 % vs 40.8 %, p < 0.001),...
Bipolar disorder is a serious psychiatric condition whose cause remains unknown. Previous diffusion MRI studies suggest white matter alterations may be involved, but standard tensor scalars provide limited information regarding potential pathophysiology. Here we used Neurite Orientation Dispersion and Density Imaging (NODDI) to examine select bundles additional changes in microstructure. We found that the uncinate fasciculus, cingulum hippocampus, corpus callosum genu showed evidence of...
This study aimed to compare the rates of disease remission evaluated using various criteria, including Boolean2.0, Boolean1.0, clinical activity index (CDAI), simplified (SDAI), and score 28 joints based on C-reactive protein (DAS28-CRP) in patients with rheumatoid arthritis (RA).
Cerebrovascular autoregulation (CVAR) is the mechanism that maintains constant cerebral blood flow by adjusting caliber of vessels. It important to have an effective, contactless way monitor and assess CVAR in patients with ischemia.The adjustment leads changes conductivity whole brain. Here, whole-brain measured magnetic induction phase shift method a valuable alternative volume for non-contact assessment CVAR. Therefore, we proposed correlation coefficient between spontaneous slow...
BACKGROUND: As a common secondary pathophysiological process in postischemic stroke (IS), cytotoxic brain edema (CBE) is an independent factor leading to poor prognosis of patients. Near-field coupling (NFC) technology has some advantages such as non-invasive, non-contact, and unimpeded penetration the skull. In theory, it can reflect difference between normal tissues through near-field phase shift (NFCPS) electromagnetic wave transmission trait. METHODS: Combining NFC detection principle...