- Neurological Disease Mechanisms and Treatments
- Cardiovascular Health and Disease Prevention
- Acute Ischemic Stroke Management
- Epigenetics and DNA Methylation
- Blood properties and coagulation
- Cancer-related molecular mechanisms research
Harbin Medical University
2022-2024
First Affiliated Hospital of Harbin Medical University
2022-2024
Background: Ischemic stroke is a highly complex disorder. This study aims to identify novel methylation changes in ischemic stroke. Methods: We carried out an epigenome-wide of using Infinium HumanMethylation 850K array (cases:controls = 4:4). 10 CpG sites 8 candidate genes from gene ontology analytics top-ranked pathway were selected validate BeadChip results 20:20). further qualified the level promoter regions 188:188). Besides, we performed subgroup analysis, dose-response relationship...
Here, we aim to investigate whether D-dimer (DD)/fibrinogen (FIB) ratio or combination of DD and FIB contribute the prognosis stroke subtypes.