A5101683633- Computational Drug Discovery Methods
- Pharmacological Effects of Natural Compounds
- Metabolomics and Mass Spectrometry Studies
- Advanced Computational Techniques and Applications
- Advanced Image and Video Retrieval Techniques
- MicroRNA in disease regulation
- Diabetes Treatment and Management
- Bone Tissue Engineering Materials
- Genomics and Phylogenetic Studies
- Helicobacter pylori-related gastroenterology studies
- RNA Research and Splicing
- Extracellular vesicles in disease
- Immune Cell Function and Interaction
- Medical Image Segmentation Techniques
- Traditional Chinese Medicine Analysis
- Environmental Toxicology and Ecotoxicology
- Protein Structure and Dynamics
- RNA modifications and cancer
- Heavy metals in environment
- Pancreatic function and diabetes
- Receptor Mechanisms and Signaling
- Inflammatory mediators and NSAID effects
- Machine Learning in Bioinformatics
- Virus-based gene therapy research
- Marine Biology and Environmental Chemistry
XinHua Hospital
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Wuhan University of Science and Technology
2021-2024
China Mobile (China)
2023-2024
Sun Yat-sen University
2017-2024
Rice Research Institute
2024
Anhui Academy of Agricultural Sciences
2024
The First Affiliated Hospital, Sun Yat-sen University
2017-2024
Second Hospital of Shandong University
2020-2024
Dalian Jiaotong University
2010-2023
Modern medicine often clashes with traditional such as Chinese herbal because of the little understanding underlying mechanisms action herbs. In an effort to promote integration both sides and accelerate drug discovery from medicines, efficient systems pharmacology platform that represents ideal information convergence pharmacochemistry, ADME properties, drug-likeness, targets, associated diseases interaction networks, are urgently needed.The database analysis (TCMSP) was built based on...
Orally administered drugs must overcome several barriers before reaching their target site. Such depend largely upon specific membrane transport systems and intracellular drug-metabolizing enzymes. For the first time, P-glycoprotein (P-gp) cytochrome P450s, main line of defense by limiting oral bioavailability (OB) drugs, were brought into construction QSAR modeling for human OB based on 805 structurally diverse drug drug-like molecules. The linear (multiple regression: MLR, partial least...
In silico prediction of drug-target interactions from heterogeneous biological data can advance our system-level search for drug molecules and therapeutic targets, which efforts have not yet reached full fruition. this work, we report a systematic approach that efficiently integrates the chemical, genomic, pharmacological information targeting discovery on large scale, based two powerful methods Random Forest (RF) Support Vector Machine (SVM). The performance derived models was evaluated...
Abstract Bone related diseases have caused serious threats to human health owing their complexity and specificity. Fortunately, the unique 3D network structure with high aqueous content functional properties, emerging hydrogels are regarded as one of most promising candidates for bone tissue engineering, such repairing cartilage injury, skull defect, arthritis. Herein, various design strategies synthesis methods (e.g., 3D‐printing technology nanoparticle composite strategy) introduced...
Abstract 3D‐printed polycaprolactone (PCL) scaffolds have been extensively studied for application in bone tissue engineering. However, PCL‐based with enhanced bioactivity and intelligent delivery capability repair remains challenging. Herein, CuS nanoparticle‐PEG soft hydrogel‐coated 3D hard (denoted as CuS‐PEG‐PCL scaffold) are rationally designed efficient regeneration. nanoparticles cross‐linked PEG hydrogel (CuS‐PEG‐hydrogel) endows the scaffold excellent photothermal properties stable...
Compound Danshen Formula (CDF) is a widely used Traditional Chinese Medicine (TCM) which has been extensively applied in clinical treatment of cardiovascular diseases (CVDs). However, the underlying mechanism administrating CDF on CVDs not clear. In this study, pharmacological effect was analyzed at systemic point view. A systems-pharmacological model based chemical, chemogenomics and data developed via network reconstruction approach. By using model, we performed high-throughput silico...
Computer-aided detection and diagnosis in ECG signals for heart diseases are gaining increasing attention. However, developing selecting the highly performing diagnostic model suitable clinical implications is still challenging. In this paper, we proposed a combined network of convolutional neural (CNN) Recurrent Neural Network (RNN), designed classification purpose. The consists 2 layers with <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Traditional Chinese Medicine (TCM) involves a broad range of empirical testing and refinement plays an important role in the health maintenance for people all over world. However, due to complexity herbs, full understanding TCM’s action mechanisms is still unavailable despite plenty successful applications TCM treatment various diseases, including especially cardiovascular diseases (CVD), one leading causes death. Thus present work, by incorporating chemical predictors, target predictors...
Background. Clinical trials reveal that multiherb prescriptions of herbal medicine often exhibit pharmacological and therapeutic superiority in comparison to isolated single constituents. However, the synergistic mechanisms underlying this remain elusive. To address question, a novel systems biology model integrating oral bioavailability drug-likeness screening, target identification, network pharmacology method has been constructed applied four clinically widely used herbs Radix Astragali...
Concentrations and ecological health risks of metals in the resuspended particles urban street dust collected from an industrial city, Baotou, China were studied. The results show that average concentrations Ba, Co, Cr, Cu, Mn, Ni, Pb, V Zn studied samples are 990.1, 56.2, 247.8, 31.5, 566.3, 26.1, 59.9, 82.2 77.5 mg kg -1 respectively, which higher than background values Inner Mongolia soil, especially Cr Pb. potential risk analysis demonstrate V, Ni low levels whereas Cu Pb to moderate...
The biogenesis and function of mature microRNAs (miRNAs) is dependent on the nuclear export miRNA precursors (pre-miRNA) by Exportin-5 (Exp5). To characterize molecular mechanisms how pre-miRNA recognized transported Exp5, we have performed 21 dynamic (MD) simulations RNA-bound Exp5 (Exp5-RanGTP-premiRNA, Exp5-RanGDP-premiRNA, Exp5-premiRNA), RNA-unbound (Exp5-RanGTP, Exp5-RanGDP, apo-Exp5), pre-miRNA. Our with standard MD, steered dynamics (SMD), energy analysis shown that (1) Free...
Given the imminent threat of influenza pandemics and continuing emergence new drug-resistant virus strains, novel strategies for preventing treating disease are urgently needed. Herbal medicine, used thousands years in combinational therapies (Herb Formula), plays a significant role stimulating host immune system vivo, meanwhile, fighting against pandemic by directly inhibiting vitro. Such potential Janus functions may spark interest therapeutic manipulation diseases. Unfortunately,...
Abstract Recent studies have shown that L-proline is a natural osmoprotectant and an antioxidant to protect cells from injuries such as caused by freezing thawing in many species including plant, ram sperm human endothelial cells. Nevertheless, this nontoxic cryoprotectant has not yet been applied mammalian oocyte vitrification. In study we evaluated the efficiency safety of new The results indicated improves survival rate vitrified oocytes, protects mitochondrial functions could be mouse
Only a small fraction of patients with cancer receiving immune checkpoint therapy (ICT) respond, which is associated tumor microenvironment (TIME) subtypes and tumor-infiltrating lymphocytes (TILs).To examine whether germline variants natural killer (NK) cells, key component the system, are TIME subtypes, abundance TILs, response to ICT, clinical outcomes, risk.This genetic association study explored examined genomic information prognosis, risk. Clinical information, RNA sequencing,...
The Dashan Region was a Se-rich region of China. In this study, 131 residents' human hair samples were collected. concentrations Se and toxic metals analyzed, the health risk estimated using concentration data. Cd As significantly higher than in East most metal increased with age (except for aged people). Furthermore, gender smoking habits might have significant impact on levels. Multivariable statistics analysis revealed that primarily originate environment are then transferred to body via...
The incidence of breast cancer is increasing rapidly around the world. Accurate classification subtype from hematoxylin and eosin images key to improve precision treatment. However, high consistency disease subtypes uneven distribution cells seriously affect performance multi-classification methods. Furthermore, it difficult apply existing methods multiple datasets. In this article, we propose a collaborative transfer network (CTransNet) for histopathological images. CTransNet consists...