A5022116113- Liver physiology and pathology
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Bone Tissue Engineering Materials
- Epigenetics and DNA Methylation
- Osteoarthritis Treatment and Mechanisms
- Cancer Cells and Metastasis
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune cells in cancer
- Bone Metabolism and Diseases
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Bone and Joint Diseases
- Tissue Engineering and Regenerative Medicine
- Hepatitis B Virus Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune Response and Inflammation
- Drug Transport and Resistance Mechanisms
- Bacterial Infections and Vaccines
- Drug-Induced Hepatotoxicity and Protection
- Virus-based gene therapy research
- Cytokine Signaling Pathways and Interactions
Shanghai University
2020-2025
New York University Shanghai
2024
Shaoxing University
2023-2024
Shenzhen University
2023
Soochow University
2023
Eastern Hepatobiliary Surgery Hospital
2012-2021
Second Military Medical University
2012-2021
Wuhan University
2012-2017
Ministry of Education of the People's Republic of China
2012
The epithelial to mesenchymal transition (EMT) plays crucial roles in the formation of body plan and also tumor invasion process. In addition, EMT causes disruption cell-cell adherence, loss apico-basal polarity, matrix remodeling, increased motility invasiveness promoting metastasis. microenvironment an important role facilitating cancer metastasis may induce occurrence cells. A large number inflammatory cells infiltrating site, as well hypoxia existing a area tumor, addition many stem...
The differentiation shift from osteogenesis to adipogenesis of bone marrow mesenchymal stem cells (BMSCs) characterizes many pathological loss conditions. Stromal cell-derived factor-1 (SDF1) is highly enriched in the for C-X-C motif chemokine receptor 4 (CXCR4)-positive hematopoietic cell (HSC) homing and tumor metastasis. In this study, we displayed CXCR4 on surface exosomes derived genetically engineered NIH-3T3 cells. CXCR4+ selectively accumulated marrow. Then, fused with liposomes...
Abstract 3D‐printed polycaprolactone (PCL) scaffolds have been extensively studied for application in bone tissue engineering. However, PCL‐based with enhanced bioactivity and intelligent delivery capability repair remains challenging. Herein, CuS nanoparticle‐PEG soft hydrogel‐coated 3D hard (denoted as CuS‐PEG‐PCL scaffold) are rationally designed efficient regeneration. nanoparticles cross‐linked PEG hydrogel (CuS‐PEG‐hydrogel) endows the scaffold excellent photothermal properties stable...
Abstract With an increasingly aging society, bone defects and fractures have become significant threats to human health quality of life. Currently, autologous allogeneic grafts remain the “gold standard” for clinical treatment repair. However, transplantation is still clinically insufficient, owing its substantial limitations, such as graft rejection, donor functional defects, risk infection. Therefore, a variety biomaterials been developed facilitate advancement tissue engineering, focus...
Abnormal subchondral bone remodeling featured by overactivated osteoclastogenesis leads to articular cartilage degeneration and osteoarthritis (OA) progression, but the mechanism is unclear. We used lymphocyte cytosolic protein 1 (Lcp1) knockout mice suppress osteoclasts in a OA model with anterior cruciate ligament transection (ACLT), Lcp1-/- showed decreased retarded degeneration. For mechanisms, activated induced type-H vessels elevated oxygen concentration, which ubiquitylated...
Diabetes mellitus is a chronically inflamed disease that predisposes to delayed fracture healing. Macrophages play key role in the process of healing by undergoing polarization into either M1 or M2 subtypes, which respectively exhibit pro-inflammatory anti-inflammatory functions. Therefore, modulation macrophage subtype beneficial for Exosomes perform an important improving osteoimmune microenvironment due their extremely low immunogenicity and high bioactivity. In this study, we extracted...
Osteoarthritis (OA), a common degenerative disease, is characterized by high disability and imposes substantial economic impacts on individuals society. Current clinical treatments remain inadequate for effectively managing OA. Organoids, miniature 3D tissue structures from directed differentiation of stem or progenitor cells, mimic native organ functions. They are useful drug testing serve as active grafts repair. However, organoid construction requires extracellular matrix-like scaffolds...
Osteoporosis (OP) is a systematic bone disease characterized by low mass and fragile microarchitecture. Conventional treatment for OP has limited efficacy long-term toxicity. Synthetic biology makes bacterial extracellular vesicle (BEVs)-based therapeutic strategies promising alternative the of OP. Here, we constructed recombinant probiotics Escherichia coli Nissle 1917-pET28a-ClyA-BMP-2-CXCR4 (ECN-pClyA-BMP-2-CXCR4), in which BMP-2 CXCR4 were overexpressed fusion with BEVs surface protein...
Mesenchymal stem cells (MSCs), which are modulated by cytokines present in the tumor microenvironment, play an important role progression. It is well documented that inflammation part of so we investigated whether stimulation MSCs inflammatory would contribute to their ability promote growth. We first showed could increase C26 colon cancer growth mice. This growth-promoting effect was further accelerated when were pre-stimulated factors IFN-γ and TNF-α. At same time, demonstrated both...
STING (also known as MITA) is critical for host defence against viruses and the activity of regulated by ubiquitination. However, deubiquitination not fully understood. Here, we show that ubiquitin-specific protease 13 (USP13) a STING-interacting protein catalyses STING. Knockdown or knockout USP13 potentiates activation IRF3 NF-κB expression downstream genes after HSV-1 infection transfection DNA ligands. deficiency results in impaired replication HSV-1. Consistently, deficient mice are...
Development of a tumor is very complex process, and invasion metastasis malignant tumors are hallmarks difficult problems to overcome. The microenvironment plays an important role in controlling fate autophagy induced by the attracting more attention. Autophagy can be several stressors modifies microenvironment, too. has dual roles growth. In this review, we discussed interaction between paradoxical on growth at different stages development.
Abstract Background The endotoxin level in the portal and peripheral veins of hepatocellular carcinoma (HCC) patients is higher lipopolysaccharide (LPS), a cell wall constituent gram-negative bacteria, has been reported to inhibit tumor growth. However, this study, we found that LPS-induced toll-like receptor 4 (TLR4) signaling was involved invasion survival, molecular mechanism investigated, Methods Four HCC lines splenic vein metastasis nude mouse model were used study ability cells...
Background/Aims: TGF-β plays a key role in the progression of various tumors. The main objective our study was to investigate whether is able regulate N-nitrosodiethylamine (DEN)-induced hepatocellular carcinoma (HCC) mouse model by inducing Treg cell polarization. Methods: HCC progression, and Foxp3 expression levels, serum TGF-β, IL10 GP73 levels as well percentage cells were analyzed healthy, HCC+SM-16 groups. effect on polarization vitro measured flow cytometric analysis. identified IHC...
Metastasis and recurrence severely impact the treatment effect of hepatocellular carcinoma (HCC). HCC complicated with cholestasis is more prone to metastasis. Previous studies have implicated pathogenesis by bile acid; however, underlying mechanism unknown yet. Glycochenodeoxycholate (GCDC) one most important component acid (BA). In present study, role GCDC in cells invasion was detected vitro vivo assays. found significantly enhance invasive potential cells; Further showed that could...
Skeletal muscle disorders have posed great threats to health. Selective delivery of drugs and oligonucleotides skeletal is challenging. Aptamers can improve targeting efficacy. In this study, for the first time, human muscle-specific ssDNA aptamers (HSM01, etc.) were selected identified with Systematic Evolution Ligands by Exponential Enrichment (SELEX). The HSM01 aptamer preferentially interacted cells