A5101423388- Liver physiology and pathology
- Autophagy in Disease and Therapy
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Hippo pathway signaling and YAP/TAZ
- Cancer Cells and Metastasis
- Mesenchymal stem cell research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Lipid metabolism and biosynthesis
- MicroRNA in disease regulation
- Pancreatic function and diabetes
- NF-κB Signaling Pathways
- Calcium signaling and nucleotide metabolism
- RNA Research and Splicing
- Extracellular vesicles in disease
- Cancer Mechanisms and Therapy
- Adenosine and Purinergic Signaling
- Immunotherapy and Immune Responses
- Endoplasmic Reticulum Stress and Disease
Shanghai Cancer Institute
2022-2025
Hubei University of Medicine
2024
Taihe Hospital
2024
Eastern Hepatobiliary Surgery Hospital
2012-2023
Second Military Medical University
2013-2023
Northwest Institute of Eco-Environment and Resources
2021
Chinese Academy of Sciences
2008-2021
Institute of Zoology
2008
Cancer Institute (WIA)
1994
Chinese Academy of Medical Sciences & Peking Union Medical College
1994
Hypoxia commonly exists in solid tumors. In this adverse condition, adaptive responses including autophagy are usually provoked to promote cell survival. our study, autophagy, a lysosomal-mediated degradation pathway, is demonstrated protective way make hepatocellular carcinoma cells be resistant chemotherapy under hypoxia. Compared with normoxia, chemotherapeutic agents-induced death hypoxia was significantly decreased, as result of the reduced apoptosis. However, when inhibited by 3-MA or...
Mesenchymal stem cells (MSCs), which are modulated by cytokines present in the tumor microenvironment, play an important role progression. It is well documented that inflammation part of so we investigated whether stimulation MSCs inflammatory would contribute to their ability promote growth. We first showed could increase C26 colon cancer growth mice. This growth-promoting effect was further accelerated when were pre-stimulated factors IFN-γ and TNF-α. At same time, demonstrated both...
Abstract Background The endotoxin level in the portal and peripheral veins of hepatocellular carcinoma (HCC) patients is higher lipopolysaccharide (LPS), a cell wall constituent gram-negative bacteria, has been reported to inhibit tumor growth. However, this study, we found that LPS-induced toll-like receptor 4 (TLR4) signaling was involved invasion survival, molecular mechanism investigated, Methods Four HCC lines splenic vein metastasis nude mouse model were used study ability cells...
Background/Aims: TGF-β plays a key role in the progression of various tumors. The main objective our study was to investigate whether is able regulate N-nitrosodiethylamine (DEN)-induced hepatocellular carcinoma (HCC) mouse model by inducing Treg cell polarization. Methods: HCC progression, and Foxp3 expression levels, serum TGF-β, IL10 GP73 levels as well percentage cells were analyzed healthy, HCC+SM-16 groups. effect on polarization vitro measured flow cytometric analysis. identified IHC...
SIRT1 is a member of the mammalian sirtuin family with ability to deacetylate histone and nonhistone proteins. The correlation between expression tumor metastasis in several types cancer has aroused widespread concern. This study investigated its prognostic value hepatocellular carcinoma (HCC). function hepatocarcinogenesis was further cell culture mouse models. Western blotting immunohistochemistry were used explore HCC lines primary clinical specimens. functions migration invasion line...
Most primary liver cancer (PLC) cases progress mainly due to underlying chronic inflammation, yet the mechanisms of inflammation-mediated PLC remain unclear. Here we uncover a TNF receptor II (TNFR2)-hnRNPK-YAP signaling axis in hepatic progenitor cells (HPC) essential for development. TNFR2, but not I (TNFR1), was required TNFα-induced activation YAP during malignant transformation HPCs and tumorigenesis. Mechanistically, heterogeneous nuclear ribonuclear protein K (hnRNPK) acted downstream...
Angiogenesis inhibitors have long been considered desirable anticancer agents. However, it was found that many tumors could develop resistance to antiangiogenesis inhibitors. Antiangiogenic therapy results in metabolic stress. Autophagy is an important survival mechanism cancer cells under stress; however, remains unknown if autophagy contributes resistance. In this study, we reported bevacizumab treatment reduced the development of new blood vessels and inhibited cell growth xenografts...
Hepatic progenitor cells (HPC) play important roles in both liver regeneration and carcinogenesis. Combined hepatocellular-cholangiocarcinoma (CHC), a malignant primary tumor with poor prognosis, is thought to be of HPC origin. However, the prognostic significance this etiology not well defined. Therefore, we retrospectively investigated relationship HPC-related pathological features long-term outcome patients CHC our department. In cohort 80 identified between 1997 2003, including 70 who...
Babaodan (BBD), a traditional Chinese medicine, has been shown to have protective effects during liver injury and ameliorate disease progression, but little is known about its effect on non-alcoholic fatty (NAFLD). The aim of this study was investigate the BBD obesity-induced NAFLD.C57BL/6 J mice were fed with normal diet, high fat diet (HFD) or HFD + for 8 weeks. Weights all recorded every 3 days. At end experiments, level livers, kidneys adipose tissues each animal weighed. Blood serum...
Society could sustain the impact of climate change by adapting to and mitigating risks from adverse effects increasing changes, so that it can continue maintaining its prospect improving wellbeing. Nevertheless, is more or less affecting society's functions at different scales, including both individuals communities. In this review, we discuss relationship between society in China aspects needs socioeconomic developing stages. The as well current spatial pattern future impacts on societies...
As the main source of extracellular matrix proteins in tumor stroma, hepatic stellate cells (HSCs) have a great impact on biological behaviors hepatocellular carcinoma (HCC). In present study, we investigated mechanism whereby HSCs modulate chemoresistance hepatoma cells. We used human HSC line lx-2 and chemotherapeutic agent cisplatin to investigate their effects HCC cell Hep3B. The results showed that resistance Hep3B was enhanced with LX-2 CM (cultured medium) exposure vitro as well...
Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in liver. Chronic inflammation is regarded as major trait of primary liver cancer. However, characteristics endogenous MSCs inflammatory environment their role occurrence cancer remain obscure.Using single-cell RNA sequencing, we identified a distinct inflammation-associated subset MSCs, namely AIF1 + CSF1R which existed before Furthermore, found this MSC subgroup...
Cancer-associated fibroblasts (CAFs) play important roles in the occurrence and development of hepatocellular carcinoma (HCC) are a key component immunosuppressive microenvironment. However, origin CAFs has not been fully elucidated. We employed single-cell sequencing technology to identify dynamic changes different subsets at time points rat primary HCC model. Inflammation-associated (Pdgfrα+ CAFs) were subsequently identified, which demonstrated significant correlation with survival...
The biological behaviors of hepatocellular carcinoma (HCC) are complex mainly due to heterogeneity progressive genetic and epigenetic mutations as well tumor environment. Hepatocyte growth factor (HGF)/c-Met signaling pathway is regarded be a prototypical example for stromal-epithelial interactions during developmental morphogenesis, wound healing, organ regeneration cancer progression. And p53 plays an important regulator Met-dependent cell motility invasion. Present study showed that 2 HCC...
Inflammatory cytokine is important in modulating injured diseases. Tumor necrosis factor-α (TNF-α), one of potent inflammatory cytokines, plays a dominant role host defense reaction. However, the concrete effect TNF-α on acute liver injury totally unclear. Here we reported and possible mechanisms induced by carbon tetrachloride (CCl4). SD male rats were equally divided into nine groups. CCl4 (1 ml/kg) was subcutaneously injected rats. Enbrel, inhibitor, intraperitoneally at dose 0, 0.25,...
Hepatocellular carcinoma (HCC) usually occurs at the late stage of chronic liver injury. Oncostatin M (OSM) is a tumor-associated cytokine highly expressed in cirrhosis and HCC patients; however, its role hepatocarcinogenesis has not been clearly elucidated. In this study, we investigated effect OSM on occurrence rat model N-diethylnitrosamine-induced HCC. overexpression significantly increased number tumor nodules shortened overall survival rats. Notably, promoted HPC activation vivo but...
Peptidylarginine deiminase IV (PADI4) is widely distributed in several tissues and the expression correlated with many pathological processes. Chemotherapy remains a major treatment alternatively to surgery for large number of patients at advanced stage hepatocellular carcinoma (HCC). However, role PADI4 chemoresistance HCC has not been identified.MTT PI/Annexin V assay were employed examine proliferation apoptosis cell lines. The MDR1 detected by Realtime PCR. GFP tagged LC3 vector electron...