A5100326968- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Autophagy in Disease and Therapy
- Neuroendocrine Tumor Research Advances
- MicroRNA in disease regulation
- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Liver Disease Diagnosis and Treatment
- Respiratory viral infections research
- Genetic factors in colorectal cancer
- Telomeres, Telomerase, and Senescence
- Adipokines, Inflammation, and Metabolic Diseases
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Pneumonia and Respiratory Infections
- Pancreatic and Hepatic Oncology Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Histiocytic Disorders and Treatments
- Hepatitis B Virus Studies
- Epigenetics and DNA Methylation
- Gestational Trophoblastic Disease Studies
- Lung Cancer Treatments and Mutations
- Colorectal and Anal Carcinomas
- Cardiovascular Disease and Adiposity
- Sarcoidosis and Beryllium Toxicity Research
Shaoxing City Women and Children Hospital
2021-2025
Shaoxing University
2025
Beijing Normal University
2024
Women's Hospital, School of Medicine, Zhejiang University
2024
Peking University
2022-2024
Peking University Cancer Hospital
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Shanxi Academy of Medical Sciences
2022-2024
Shanxi Medical University
2022-2024
State Key Laboratory of Medicinal Chemical Biology
2022-2023
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease with unknown etiology, high mortality and limited treatment options. It characterized by myofibroblast proliferation extensive deposition of extracellular matrix (ECM), which will lead to fibrous the destruction structure. Transforming growth factor-β1 (TGF-β1) widely recognized as central pathway fibrosis, suppression TGF-β1 or TGF-β1-regulated signaling may thus offer potential antifibrotic therapies....
Cisplatin (DDP) is the first-line drug for treatment of gastric cancer (GC). However, DDP resistance common. Autophagy, which closely related to chemoresistance, a process resolving and recycling proteins damaged cellular organs. Additionally, O-6-methylguanine-DNA methyltransferase (MGMT) responsible alkylating resistance. relationship between autophagy MGMT in response GC still unknown. In present study, we determined that induced by decreases chemosensitivity cell lines. may have...
Pediatric non-alcoholic fatty liver disease (NAFLD) is emerging as a worldwide health concern with the potential to advance cirrhosis and cancer. NAFLD can also directly contribute heart problems through inflammation insulin resistance, even in individuals without other risk factors. The pathological mechanisms of are linked functional differences miRNAs different biological environments. miRNA serum exosomes may reflect state changes systemic metabolism, while be associated physiological...
Abstract Small cell cervical carcinoma (SCCC) is a rare but aggressive malignancy. Here, we report human papillomavirus features and genomic landscape in SCCC via high-throughput HPV captured sequencing, whole-genome whole-transcriptome OncoScan microarrays. HPV18 infections integrations are commonly detected. Besides MYC family genes (37.9%), identify SOX (8.4%), NR4A (6.3%), ANKRD (7.4%), CEA (3.2%) as HPV-integrated hotspots. We construct the local haplotype around sites, find tandem...
It is now understood that the Coronavirus disease 2019 (COVID-19) pandemic and its associated containment measures have influenced epidemiology of other respiratory viruses. This study aimed to characterize virus infections in pediatric patients hospitalized for acute (ARIs) East China both prior during COVID-19 pandemic.We collected nasal secretions from 9782 ARI admitted Shaoxing Maternal Child Health Care Hospital between January 2018 December 2022. We analyzed compared changes viral...
Background: Accumulating evidence demonstrates that perivascular adipose tissue (PVAT) plays an important role in maintaining vascular homeostasis. The formation of macrophage foam cells is a central feature atherosclerosis. This study aimed to evaluate the effect PVAT-derived exosomes (EXOs) on lipid accumulation macrophages and verify anti-atherogenic characteristics PVAT. Methods Results: We extracted EXOs from PVAT subcutaneous (SCAT) wild-type C57BL/6J mice. After coincubation, were...
Fusobacterium nucleatum ( Fn ) is reportedly involved in poor prognosis of oesophageal squamous cell carcinoma (ESCC), but the responsible mechanisms remain unclear. The present study aimed to explore function ESCC progression, and identify key genes or signals involved. Fluorescence situ hybridization quantitative PCR assays were applied measure abundance tissues, finding that tissues displayed a higher compared adjacent tissues. Furthermore, advanced was found be than early stage ESCC....
Cervical cancer is characterized by a complex immunosuppressive tumor microenvironment (TME). Disulfidptosis recently identified form of programmed cell death that has emerged as crucial factor in tumorigenesis. However, the research on specific involvement disulfidptosis within TME still its early stages. Under glucose starvation, SiHa and HeLa cells underwent experiments employing diverse inhibitors SLC7A11 knockdown to observe their impact survival. TCGA-CESC cohort was subjected...
Background . Recent evidence demonstrated that the circulating levels of omentin-1 are related to presence ischemic heart disease and failure. However, plasma in patients with nonischemic dilated cardiomyopathy (DCM), which is most common etiology failure, have yet be investigated. Methods Plasma adiponectin were measured 100 DCM 45 healthy controls. Results significantly decreased compared control group, whereas increased group. negatively correlated (<mml:math...
Abstract The study aimed to explore predictors of Mycoplasma pneumoniae pneumonia (MPP) in adults and develop a nomogram predictive model order identify high-risk patients early. We retrospectively analysed the clinical data total 337 adult with community-acquired (CAP) divided them into MPP non-MPP groups according whether they were infected MP. Univariate multivariate logistic regression analyses used screen independent developed model. Receiver operating characteristic (ROC) curve,...
Gap Junction Protein Alpha 1 (GJA1) belongs to the gap junction family and has been widely studied in cancers. We evaluated role of GJA1 cervical cancer (CC) using public data from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) database. difference expression level between CC normal tissues was analyzed by Profiling Interactive Analysis (GEPIA), six GEO datasets, Human (HPA). relationship clinicopathological features chi-squared test logistic regression. Kaplan–Meier survival...
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are used as standard therapies for advanced nonsmall cell lung cancer (NSCLC) patients with EGFR mutation positive. Because these targeted could cause tumor necrosis and shrinkage, the purpose of study is to search a value optimal shrinkage an appropriate indicator outcome NSCLC. A total 88 NSCLC enrollees 3 clinical trials (IRESSA registration trial, TRUST ZD6474 study), who received Gefitinib (250 mg, QD), Erlotinib...