A5101439302- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pulmonary Hypertension Research and Treatments
- Computational Drug Discovery Methods
- Lung Cancer Treatments and Mutations
- Circular RNAs in diseases
- Flavonoids in Medical Research
- Cancer, Hypoxia, and Metabolism
- Glycosylation and Glycoproteins Research
- Sarcoidosis and Beryllium Toxicity Research
- MicroRNA in disease regulation
- Bone and Dental Protein Studies
- RNA modifications and cancer
- Diverse Scientific Research Studies
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Sesquiterpenes and Asteraceae Studies
- Inflammasome and immune disorders
- Natural product bioactivities and synthesis
- Cancer Research and Treatments
- Phytochemicals and Antioxidant Activities
- PI3K/AKT/mTOR signaling in cancer
- Plant Toxicity and Pharmacological Properties
- NF-κB Signaling Pathways
- SARS-CoV-2 detection and testing
- Chemokine receptors and signaling
Nankai University
2015-2024
Central South University
2024
Second Xiangya Hospital of Central South University
2024
Hunan Children's Hospital
2024
Tianjin International Joint Academy of Biomedicine
2015-2023
State Key Laboratory of Medicinal Chemical Biology
2018-2023
University of Tübingen
2022
Jinyintan Hospital
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2018
Peking Union Medical College Hospital
2017
Abstract In this study, we identified a novel circRNA, circ_0002483, and further investigated its functions in the progression Taxol resistance of NSCLC. We found that circ_0002483 was expressed at low levels NSCLC tissues cell lines. Functional assays indicated overexpression significantly inhibited proliferation invasion vitro vivo enhanced sensitivity cells to Taxol. Mechanistically, sponge multiple miRNAs including miR-182-5p (also named miR-182), miR-520q-3p, miR-582-3p, miR-587,...
The coronavirus disease 2019 (COVID-19) has spread widely around the world and seriously affected human health of tens millions people. In view lacking anti-virus drugs target to SARS-CoV-2, there is an urgent need develop effective new drugs. this study, we reported our discovery SARS-CoV-2 M pro inhibitors. We selected 15 natural compounds, including 7 flavonoids, 3 coumarins, 2 terpenoids, one henolic, aldehyde steroid compound for molecular docking enzymatic screening. Myricetin were...
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease, and the molecular mechanisms remain poorly understood. Our findings demonstrated that pyruvate kinase M2 (PKM2) promoted progression by directly interacting with Smad7 reinforcing transforming growth factor-β1 (TGF-β1) signaling. Total PKM2 expression portion of tetrameric form elevated in lungs fibroblasts were derived from mice bleomycin (BLM)-induced fibrosis. Pkm2 deletion markedly alleviated BLM-induced...
// Yuan Qin 1, 2, * , Qiang Zhang Shan Lee Wei-long Zhong Yan-rong Liu 2 Hui-juan Dong Zhao Shuang Chen Ting Xiao Jing Meng Xue-shuang Wang Bo Sun Ting-ting Dai Cheng Yang Tao Hong-gang Zhou 1 State Key Laboratory of Medicinal Chemical Biology and College Pharmacy, Nankai University, Tianjin, China Tianjin Molecular Drug Research, International Joint Academy Biomedicine, These authors have contributed equally to this work Correspondence to: Sun, e-mail: sunrockmia@hotmail.com Zhou,...
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease with unknown etiology, high mortality and limited treatment options. It characterized by myofibroblast proliferation extensive deposition of extracellular matrix (ECM), which will lead to fibrous the destruction structure. Transforming growth factor-β1 (TGF-β1) widely recognized as central pathway fibrosis, suppression TGF-β1 or TGF-β1-regulated signaling may thus offer potential antifibrotic therapies....
Parthenolide (PTL) is a natural molecule isolated from Tanacetum parthenium that exhibits excellent anti-inflammatory and antitumor activities. Pulmonary fibrosis (PF), especially idiopathic pulmonary (IPF), chronic lung disease lacks proven effective therapy. The present study evaluated the therapeutic effect of PTL on PF. Serum-starved primary fibroblasts HFL1 cells were treated with different doses PTL, cell viability migration rate measured. Western blot analysis dual-luciferase assay...
Doxycycline have been reported to exert anti-cancer activity and assessed as agents in clinical trials. However, the direct targets of doxycycline cancer cells remain unclear. In this study, we used a chemical proteomics approach identify Protease-activated receptor 1 (PAR1) specific target inhibition doxycycline. Binding assays single-molecule imaging were performed confirm PAR1. The effect on multi-omics cell functions based PAR1/thrombin model. Molecular docking molecular dynamic...
Circular RNAs (circRNAs) are single‐stranded which form a covalently closed continuous loop. Although originally shown to be non‐protein‐coding, some circRNAs can give rise micropeptides. have also been play essential regulatory roles in variety of developmental and disease processes. In previous study, hsa_circ_0030998 was identified as circRNA downregulated lung cancer, but its potential implications mechanisms cancer were not addressed. Here, we showed that overexpressing circ_0030998...
The super-enhancer, a cluster of enhancers with strong transcriptional activity, has become one the most interesting topics in recent years. This study aimed to investigate pathogenic super-enhancer-driven genes IBD and screen therapeutic drugs based on results. In this study, through analysis differentially expressed colitis patients from GEO database super-enhancer-associated database, we found that super-enhancer PCK1 EFNA1 were simultaneously regulated by transcription factor CEBPB two...
Hepatocellular carcinoma (HCC) ranks as one of the most common and lethal malignancies worldwide. A better understanding mechanism responsible for HCC metastasis will be helpful treatment patients. Thymidine phosphorylase (TP), a key enzyme that catalyzes conversion thymidine to thymine deoxyribose-1-phosphate, was demonstrated promote invasion in our study. Clinical retrospective analysis revealed metastatic tumor tissues have higher TP expression, expression significantly correlated with...
Locally advanced rectal cancer (LARC) is frequently treated with neoadjuvant chemoradiotherapy (NACRT) to reduce the risk of local recurrence and improve survival. Tumour response NACRT variable may influence prognosis after subsequent surgery. This study compared prognostic values tumour regression grade (TRG) pathological (ypTNM) downstaging in patients Stage II III followed by curative surgery.This included 185 LARC long-course radiotherapy (45 Gy 25 fractions) plus 5-fluorouracil over 5...
DJ-1 is a novel oncogene that can transform NIH3T3 cells in cooperation with the activated ras gene. appears to have its greatest effect on tumourigenesis, and it may greater impact early-stage lung cancers. In this study, we proposed investigate clinical value of protein early diagnosis cancer compared diagnostic other biomarkers. Preoperative serum levels were measured 300 patients benign pulmonary disease (n = 44) healthy volunteers 64). Using tissue microarrays immunohistochemical...
Most antiangiogenic inhibitors targeting endothelium-dependent vessels cannot inhibit tumor growth but promote invasion and metastasis in some patients. Vasculogenic mimicry (VM) employs mechanisms that differ from those used to construct vessels. Inhibiting VM may be a novel strategy against alternative vascularization. In this paper, myricetin was selected among several flavonoid compounds as an effective PAR1 antagonist. two different hepatocellular carcinoma (HCC) cell lines...
At present, viral nucleic acids are generally sampled using throat swabs and detected by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). However, the capacity for SARS-CoV-2 acid detection is largely limited number of instruments, kits, experienced laboratory personnel available. These limitations have caused low screening efficiency, which leads to a lag in identifying potential infections may then exacerbate spread COVID-19 (Carter et al. 2020). Therefore,...
Sesquiterpene lactones (SL) have a wide range of applications in anti-tumor and anti-inflammatory therapy. However, the pharmacological mechanism such substances is not clear. In this study, parthenolide (PTL) was used as an example to explore effect natural molecules their common mechanism. We showed that PTL inhibited proliferation migration by reverse EMT via ERK2/NF-κB/Snail pathway vivo vitro. Interestingly, Multiple potential targets contain Gly-Leu-Ser/Lys-"co-adaptation pocket". This...
Numerous researches have reported on the regulatory network of liver regeneration induced by partial hepatectomy (PH). However, information key molecules and/or signaling pathways regulating termination stage remains limited. In this study, we identify hepatic mitotic arrest deficient 1 (MAD1) as a crucial regulator transforming growth factor β (TGF-β) in hepatocyte to repress regeneration. MAD1 has low expression level at rapid proliferation phase but significantly increases We show that...