A5084839714- Computational Drug Discovery Methods
- Flavonoids in Medical Research
- Diverse Scientific Research Studies
- Insect-Plant Interactions and Control
- Antibiotics Pharmacokinetics and Efficacy
- Inflammatory Myopathies and Dermatomyositis
- SARS-CoV-2 and COVID-19 Research
- Meat and Animal Product Quality
- Protein Degradation and Inhibitors
- Angiogenesis and VEGF in Cancer
- Heme Oxygenase-1 and Carbon Monoxide
- Gastroesophageal reflux and treatments
- Potassium and Related Disorders
- Medicinal plant effects and applications
- Mosquito-borne diseases and control
- Identification and Quantification in Food
- Blood Coagulation and Thrombosis Mechanisms
- Neurobiology and Insect Physiology Research
- Cancer Cells and Metastasis
- Histone Deacetylase Inhibitors Research
- Aquaculture disease management and microbiota
- Immune Response and Inflammation
- Eosinophilic Disorders and Syndromes
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
Shandong Provincial QianFoShan Hospital
2024
Shandong First Medical University
2024
Nankai University
2020-2023
State Key Laboratory of Medicinal Chemical Biology
2020-2023
University of Ottawa
2023
Tianjin International Joint Academy of Biomedicine
2020-2022
Qingdao Agricultural University
2018-2022
Northeast Normal University
2021
Yonsei University
2020
Severance Hospital
2020
The coronavirus disease 2019 (COVID-19) has spread widely around the world and seriously affected human health of tens millions people. In view lacking anti-virus drugs target to SARS-CoV-2, there is an urgent need develop effective new drugs. this study, we reported our discovery SARS-CoV-2 M pro inhibitors. We selected 15 natural compounds, including 7 flavonoids, 3 coumarins, 2 terpenoids, one henolic, aldehyde steroid compound for molecular docking enzymatic screening. Myricetin were...
Abstract Parasitic plants rarely attack themselves, suggesting the activity of a kin-avoidance mechanism. In root parasitic plant Phtheirospermum japonicum , prehaustorium formation is triggered by host-secreted haustorium-inducing factors (HIFs), but it unresponsive to its own exudates. Here we report identification spo ntaneous pre h austorium 1 ( spoh1 ) mutant, which forms prehaustoria without external HIFs. harbors point mutation in gene encoding UDP-glycosyltransferase GT72B1, an...
Histone deacetylases (HDACs) exhibit increased expression in cancer and promote oncogenesis via the acetylation of or interactions with key transcriptional regulators.HDAC inhibitors (HDACis) decrease HDAC activity to selectively inhibit occurrence development tumors.Our study screened obtained a new HDACi structure.In vitro experiments have showed that among leads, Z31216525 significantly inhibited proliferation induced apoptosis epithelial ovarian (EOC) cells.In vivo demonstrated compared...
Most antiangiogenic inhibitors targeting endothelium-dependent vessels cannot inhibit tumor growth but promote invasion and metastasis in some patients. Vasculogenic mimicry (VM) employs mechanisms that differ from those used to construct vessels. Inhibiting VM may be a novel strategy against alternative vascularization. In this paper, myricetin was selected among several flavonoid compounds as an effective PAR1 antagonist. two different hepatocellular carcinoma (HCC) cell lines...
Jasmonates are critical plant hormones, mediating stress response in plants and regulating growth development. The jasmonate receptor is a multi-component complex, composed of Arabidopsis SKP-LIKE PROTEIN1 (ASK1), CORONATINE INSENSITIVE 1 (COI1), inositol phosphate (InsP), ZIM-domain protein (JAZ). COI1 acts as signaling hub that binds with each component. InsP suggested to play important roles the hormone perception. How structural changes upon binding InsP, JA-Ile, JAZ not well understood....
A simple, rapid sample extraction method for the determination of FQs was developed. Fishery samples were extracted with 2% 5-sulfosalicylic acid dihydrate and extracts analyzed directly without any further purification or clean-up procedures. The determined standards in concentration range 0.1-25.6 μg L−1, limit detection (LOD) 0.1 L−1. matrix interference originated from fishery eliminated by did not interact horseradish peroxidase (HRP) labeled IgG western blotting. No significant...
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic interstitial lung disease of unknown etiology. At present, the mortality rate deadly still very high, while existing treatments only delay progression and improve quality life patients. Lung cancer (LC) most fatal in world. In recent years, IPF has been considered to be an independent risk factor for development LC. The incidence increased patients with also significantly inflicted two diseases. this study, we evaluated...
YH4808 is a novel potassium-competitive acid blocker that was developed as therapeutic agent for gastric acid-related diseases; it may replace proton pump inhibitors, which are widely used in combination with amoxicillin and clarithromycin Helicobacter pylori eradication. We compared the pharmacokinetic (PK) profiles safety of amoxicillin, clarithromycin, monotherapies or evaluating potential drug interactions. An open-label, randomized, single-dose, Latin-square (4 × 4) crossover study...
Hepatocellular carcinoma (HCC) is the most common malignant liver disease in world. Existing screening and early diagnosis methods are not highly sensitive for HCC, patients likely to develop middle advanced stages before being diagnosed. Therefore, finding new efficient treatment has become an urgent problem. We aimed at verifying cancer markers by combining informatics analysis with experimental exploration provide ideas of clinical cancer. used two different bioinformatic pipelines...
Abstract Severe acute syndrome coronavirus 2(SARS-CoV-2) caused the global pandemic of COVID-19 since December 2019. Although most COVID-19’s patients are mild or common, severe have sepsis by cytokine storm, which greatly increases case fatality rate. Moreover, there is no effective drug that can resist novel so far, it’s urgent to develop antiviral for SARS-CoV-2. In our research, we screened 29 compounds with a score lower than -6 from 35 flavonoid molecular docking. (-)-Gallocatechin...
In today's society, people are increasingly mindful of their daily dietary habits, with particular attention given to sugar consumption. While provides a quick source energy, excessive intake can lead oxidative stress and have detrimental health effects. It has been linked number illnesses, including obesity, type 2 diabetes, dental problems, even cancer. Additionally, lasting effects on skin through process known as antiglycation. Hence, the call reduce or combat is gaining traction. The...