Kun Zhang

ORCID: 0009-0002-0808-482X
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About
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Research Areas
  • Insect and Pesticide Research
  • Insect-Plant Interactions and Control
  • Insect Resistance and Genetics
  • Natural product bioactivities and synthesis
  • Indoor and Outdoor Localization Technologies
  • Insect symbiosis and bacterial influences
  • Genomics, phytochemicals, and oxidative stress
  • Biochemical and Structural Characterization
  • Insect Pest Control Strategies
  • Antimicrobial Peptides and Activities
  • MicroRNA in disease regulation
  • Robotics and Sensor-Based Localization
  • Speech and Audio Processing
  • Plant and animal studies
  • Biological Activity of Diterpenoids and Biflavonoids
  • Insect and Arachnid Ecology and Behavior
  • Ultra-Wideband Communications Technology
  • RNA regulation and disease
  • Pomegranate: compositions and health benefits
  • Energy Efficient Wireless Sensor Networks
  • Robotic Path Planning Algorithms
  • Target Tracking and Data Fusion in Sensor Networks
  • Innovative Energy Harvesting Technologies
  • Radio Wave Propagation Studies
  • Kruppel-like factors research

Kunming University
2025

China University of Petroleum, Beijing
2025

Hainan University
2017-2024

Chinese Academy of Agricultural Sciences
2021-2024

Sanya University
2023-2024

Nanyang Normal University
2022-2024

Feed Research Institute
2023-2024

Sichuan University
2024

Ministry of Agriculture and Rural Affairs
2023

Guangdong University of Technology
2012-2023

Abstract The low activity and yield of antimicrobial peptides (AMPs) are pressing problems. improvement through modification heterologous expression, a potential way to solve the problem, is research hot-pot. In this work, new plectasin-derived variant L-type AP138 (AP138L-arg26) was constructed for study recombination expression druggablity. As result, total protein concentration AP138L-arg26 3.1 mg/mL in Pichia pastoris X-33 supernatant after 5 days induction 5-L fermenter. recombinant...

10.1007/s00253-023-12947-w article EN cc-by Applied Microbiology and Biotechnology 2024-01-13

Neonicotinoids have been widely used to control pests with remarkable effectiveness. Excessive insecticides led serious insect resistance. Mutations of the nicotinic acetylcholine receptor (nAChR) are one reasons for neonicotinoid resistance conferred in various agricultural pests. Two mutations, V65I and V104I, were found nAChR β1 subunit two neonicotinoid-resistant aphid populations. However, specific functions mutations remain unclear. In this study, we cloned identified four subunits...

10.1021/acs.jafc.3c09456 article EN Journal of Agricultural and Food Chemistry 2024-03-05

In recent years, higher-order sonic topological insulators have transformed our understanding of how waves are trapped, and led to the discovery unique edge corner states resistant small perturbations. Programmable coding a insulator realizes logic or xor gates. Despite rapid advancements in this field, it has been significant challenge achieve programmable binary codes waves. We propose solution challenge, based on states. Using parity phase difference two sources, we can realize...

10.1103/physrevapplied.23.014010 article EN Physical Review Applied 2025-01-06

Summary Deep coalbed methane (CBM) is an important unconventional gas resource following shallow coal seam development, vital for energy supply and security. The deep seams in the study area are characterized by low porosity, permeability, high stress, strong plasticity, leading to significant differences fracturing effectiveness production among wells. This highlights need sweet spot identification seams. focuses on developing evaluating integrated geological engineering spots (ESSs)...

10.2118/224418-pa article EN SPE Journal 2025-03-01

Parkinson's disease (PD) is a neurodegenerative disease, hallmark by the formation of misfolded and aggregated α-synuclein proteins. The expression potential microRNA (miRNA) candidates isolated from serum cerebrospinal fluid (CSF) exosomes PD patients was assessed for their diagnostic value role as biomarkers explored. In this study, we characterize level miRNAs in blood sera explore PD. A total 209 having an onset PD, along with 60 (ND) disorders 50 healthy controls were enrolled. Blood...

10.1155/2022/8683877 article EN cc-by Parkinson s Disease 2022-04-06

The effectiveness of pyrethroid insecticides is seriously threatened by knockdown resistance (kdr), which induced in insects inherited single-nucleotide polymorphisms the voltage-gated sodium channel (VGSC) gene. VGSC's L1014F substitution results classic kdr mutation, found many pest species. Other substitutions L1014 locus, such as L1014S, L1014C, L1014W, and L1014H, were also reported. In 2022, a new amino acid substitute L1014S Blattella germanica was first discovered China. We modified...

10.1021/acs.jafc.2c05625 article EN Journal of Agricultural and Food Chemistry 2023-01-26

The chemical compositions of essential oils (EOs) extracted from Curcuma kwangsiensis rhizomes collected six natural habitats in P. R. China were evaluated using gas chromatography/mass spectrometry (GC/MS). Fifty-seven components identified the EOs, and their main constituents 8,9-dehydro-9-formyl-cycloisolongifolene (2.37 - 42.59%), germacrone (6.53 22.20%), l-camphor (0.19 6.12%). EOs exhibited different DPPH radical-scavenging activities (IC50 , 2.24 31.03 μg/ml), with activity most...

10.1002/cbdv.201700020 article EN Chemistry & Biodiversity 2017-04-11

The emergence of drug-resistant Staphylococcus aureus (S. aureus) has resulted in infections humans and animals that may lead to a crisis the absence highly effective drugs. Consequently, development alternative or complementary antimicrobial agents is urgently needed. Here, series peptides derived from AP138 were designed with high expression, activity, antibiofilm properties via bioinformatics. Among them, best peptide, A24 (S9A), demonstrated greatest stability bactericidal efficiency...

10.1038/s42003-024-07216-z article EN cc-by-nc-nd Communications Biology 2024-11-27

We investigated the effects of Wolbachia infection on mtDNA variation in spider mites by sequencing a portion mitochondrial cytochrome oxidase I (COI) gene from 198 individuals known status. Four strains were described current study, namely wUrtOri1, wUrtOri2, wUrtOri3 and wUrtCon1. As predicted, haplotype nucleotide diversity lower infected than uninfected individuals. However, these data are not entirely concordant with surface protein wolbachia (wsp) sequence both found same haplotype....

10.1111/j.1365-2583.2010.01066.x article EN Insect Molecular Biology 2011-01-04

One of the key advantages using Drosophila melanogaster as a genetic model organism is ability to conduct saturation mutagenesis screens identify genes and pathways underlying given phenotype. Despite large number tools developed facilitate downstream cloning mutations obtained from such screens, current procedure remains labor intensive, time consuming, costly. To address this issue, we designed an efficient strategy for rapid identification heterozygous in fly genome by combining rough...

10.1101/gr.102921.109 article EN Genome Research 2010-05-14

Abstract Aphids exhibit wing polyphenism. Winged and wingless aphid morphs are produced by parthenogenesis depending on population density host plant quality. Recent studies showed that microRNAs in alate apterous individuals have differential expression involved dimorphism of Acyrthosiphon pisum. From which miR-92a-1-p5 can target the mRNA flight muscle gene flightin vitro, but what effect they development is unclear. Here with nanocarrier-delivered RNA interference (RNAi) method, was...

10.1093/jisesa/ieac033 article EN cc-by-nc-nd Journal of Insect Science 2022-05-01

The citrus red mite, Panonychus citri (McGregor) (Acari: Tetranychidae), is regarded as one of the most important pests in many countries, such Japan, Spain, and China. In this study, mitochondrial cytochrome oxidase subunit I gene was used to analyze genetic diversity population structure 15 P. populations collected from three (Citrus spp.) planting regions Our analysis found that these had relatively low diversities. Bayesian tree haplotype network showed 22 haplotypes formed two lineages...

10.1603/ec09392 article EN Journal of Economic Entomology 2010-12-01

Transplantation of neural progenitor cells (NPCs) derived from human-induced pluripotent stem (hiPSCs) is one the promising treatment strategies for motor neuron diseases (MNDs). However, inefficiency in committed differentiation NPCs vivo limits its application. Here, we tried to establish a potential therapeutic strategy MNDs by directional hiPSCs engineered with (MN) specific transcription factors and Tet-On system.We three MN-specific system. The were directly transplanted into...

10.1111/cpr.13319 article EN Cell Proliferation 2022-08-09

The western flower thrips Frankliniella occidentalis, a worldwide agricultural pest, has developed resistance to an array of insecticides. Spinosad confers apparent fitness cost in F. occidentalis. In the present study, we compared reproductive capacities, ovary development, and expression vitellogenin (Vg) gene spinosad-susceptible (Ivf03) -resistant (NIL-R) near isogenetic lines occidentalis order clarify reason for spinosad resistance.The NIL-R strain exhibited 17.9% decrease fecundity...

10.1002/ps.7253 article EN Pest Management Science 2022-10-20
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