A5100319659- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Esophageal Cancer Research and Treatment
- Urologic and reproductive health conditions
- Reconstructive Surgery and Microvascular Techniques
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Testicular diseases and treatments
- Organ and Tissue Transplantation Research
- Cleft Lip and Palate Research
- Digital Imaging in Medicine
- Thyroid Cancer Diagnosis and Treatment
- Surgical Sutures and Adhesives
- Lung Cancer Treatments and Mutations
- Facial Rejuvenation and Surgery Techniques
- Mesenchymal stem cell research
- COVID-19 Clinical Research Studies
- Sarcoma Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Nausea and vomiting management
- Genital Health and Disease
- Colorectal and Anal Carcinomas
- CAR-T cell therapy research
Simcere Pharmaceutical (China)
2025
Affiliated Hospital of Jining Medical University
2024-2025
First People's Hospital of Foshan
2025
Huazhong University of Science and Technology
2016-2025
Tongji Hospital
2016-2025
Hangzhou Cancer Hospital
2015-2025
Shandong First Medical University
2025
Fujian Medical University
2019-2024
Union Hospital
2016-2024
Huazhong Agricultural University
2022-2024
PurposeTo evaluate the performance of a multi-parametric MRI (mp-MRI)-based radiomics signature for discriminating between clinically significant prostate cancer (csPCa) and insignificant PCa (ciPCa).Materials methodsTwo hundred eighty patients with pathology-proven were enrolled randomly divided into training test cohorts. Eight nineteen features extracted from mp-MRI each patient. The minority group in cohort was balanced via synthetic over-sampling technique (SMOTE) method. We used...
•This is the first phase III trial comparing SCRT followed by immunochemotherapy to LCRT chemotherapy in LARC.•Neoadjuvant CAPOX and camrelizumab significantly improved pCR versus neoadjuvant CAPOX.•Neoadjuvant demonstrated promising efficacy LARC patients with pMMR/MSS.•The treatment arm provides opportunity for organ preservation a watch-and-wait strategy.•No unexpected toxicities were observed, safety profile of was manageable. BackgroundNeoadjuvant short-course radiotherapy (SCRT) (a...
To investigate the clinical features and prognosis of severe central nervous system (CNS) injury in children caused by coronavirus disease 2019 (COVID-19). We retrospectively studied confirmed pediatric cases COVID-19 complicated with CNS injury. Nine patients diagnosed were admitted to intensive care unit Affiliated Hospital Jining University from December 1, 2022 January 12, 2023. Of nine patients, seven male (77.78%). Five aged ≥ 10 years, others 1–2 years old. All had fever, eight...
More and more evidence has confirmed the efficacy safety of immunotherapy drugs, such as camrelizumab pembrolizumab. There are several phase-I/II studies showing that toripalimab an acceptable profile promising clinical activity in patients with advanced solid tumors. To further confirm its safety, aim study was to evaluate combined docetaxel cisplatin neoadjuvant therapy for locally esophageal squamous cell carcinoma (ESCC).This investigator-initiated, open-label, non-randomized,...
Background: The tear trough and palpebromalar groove are of increasing interest to plastic surgeons, but their mechanisms formation remain unclear. This study evaluated the anatomical foundation for groove. Methods: Sagittal dissection layered were performed on 20 elderly cadaveric hemifaces with obvious troughs grooves 16 young without grooves. Cross-sectional specimens tissue sections compared between two groups identify differences. Results: malar fat pad becomes atrophic descends aging....
Background: Cytomegalovirus (CMV) infection is common in the digestive and central nervous systems can infect entire tract from mouth to rectum. In immunocompromised patients, CMV prone develop into disease, especially Acquired Immune Deficiency Syndrome (AIDS) patients. Severe cases may accelerate progression of AIDS patients form systemic infection. Timely diagnosis treatment are very important for prognosis Case Presentation: this paper, we report a 36-year-old man with Human...
Targeted next-generation sequencing (tNGS) is a high-throughput and cost-effective diagnostic alternative for pneumonia, with the ability to simultaneously detect pathogens, antimicrobial resistance genes, virulence genes. We aimed explore applicability of tNGS in co-detection responsible (AMR) genes patients pneumonia. A prospective study was conducted among suspected pneumonia at Ruijin Hospital from March 1 May 31, 2023. Bronchoalveolar lavage fluid (BALF) or sputum samples were collected...
To explore and compare the value of 131I-TFMP-Y4 131I-Caerin 1.1 in internal irradiation therapy for hepatocellular carcinoma. (1) 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) analysis revealed inhibitory effects Caerin TFMP-Y4 on Hepg2 LO2 cell growth. (2) The chloramine-T method was used to prepare 131I-TFMP-Y4. (3) Uptake elution assays that cells bound retained 131I-TFMP-Y4, were verified with cellular proliferation/toxicity assays. (4) A hormonal nude mouse model...
Atelectasis is a common postoperative complication in patients with obesity, contributing to respiratory insufficiency, pneumonia and poor clinical outcomes. Studies have shown that driving pressure (DP)-guided individualised positive end-expiratory can improve mechanics oxygenation, while also reducing the incidence of atelectasis other pulmonary complications (PPCs). However, effect this ventilation strategy on morbid obesity remains unclear. The trial presented here aims use lung...
Distinguishing between benign and malignant testicular lesions on clinical magnetic resonance imaging (MRI) is crucial for guiding treatment planning. However, conventional MRI-based radiomics to identify cancer requires expert machine learning knowledge. This study aims investigate the potential of utilizing automatic (AutoML) based MRI diagnose without need algorithm optimization. Retrospective preoperative scans from 115 patients diagnosed with disease through pathology were obtained. A...
Abstract Background Anoikis resistance is a hallmark characteristic of oncogenic transformation, which crucial for tumor progression and metastasis. The aim this study was to identify validate novel anoikis‐related prognostic model prostate cancer (PCa). Methods We collected gene expression profile, single nucleotide polymorphism mutation copy number variation (CNV) data 495 PCa patients from the TCGA database 140 samples MSKCC dataset. extracted 434 genes unsupervised consensus cluster...
Objective: To evaluate the performance of a T2-weighted image (T2WI)-based radiomics signature for differentiating between seminomas and nonseminomas. Materials Methods: In this retrospective study, 39 patients with testicular germ-cell tumors (TGCTs) confirmed by radical orchiectomy were enrolled, including 19 cases 20 All underwent 3T magnetic resonance imaging (MRI) before orchiectomy. Eight hundred fifty-one features extracted from T2WI each patient. Intra- interclass correlation...
Background As a developing country with the world's largest population in state of economic transition, reforms to China's health system, including community services (CHS), are very complex and difficult. The aim this study is provide evidence policy recommendations for sustainable development CHS China, which could also be applicable other countries. Methods A cross-sectional survey was conducted door-to-door face-to-face Wuhan city, central China sample 1134 individuals aged 15 older....
Our previous researches have identified immunoevasive subtype muscle‐invasive bladder cancer (MIBC) characterized with immune cells infiltration patterns. study explored the clinical significance, immunoregulatory role and therapeutic value of intratumoral IL22‐producing in MIBC. Two hundred fifty‐nine formalin‐fixed paraffin‐embedded MIBC samples 83 freshly resected tissues 391 TCGA were retrospectively evaluated. Immunohistochemistry flow cytometry applied to identify cell functional...