A5039219524- Acute Kidney Injury Research
- Developmental Biology and Gene Regulation
- Chronic Kidney Disease and Diabetes
- Retinal Development and Disorders
- Organ Transplantation Techniques and Outcomes
- Hedgehog Signaling Pathway Studies
- Cardiac Ischemia and Reperfusion
- Hippo pathway signaling and YAP/TAZ
- Neuroscience and Neuropharmacology Research
- Craniofacial Disorders and Treatments
- Renal Transplantation Outcomes and Treatments
- Advanced Combustion Engine Technologies
- Cellular transport and secretion
- Renal and related cancers
- Ocular Oncology and Treatments
- Systemic Lupus Erythematosus Research
- Ocular Disorders and Treatments
- Paraquat toxicity studies and treatments
- Wind Energy Research and Development
- Radiomics and Machine Learning in Medical Imaging
- Wave and Wind Energy Systems
- Structural Health Monitoring Techniques
- Maritime Transport Emissions and Efficiency
- Axon Guidance and Neuronal Signaling
- Cellular Mechanics and Interactions
Shanghai Jiao Tong University
2019-2024
Renji Hospital
2019-2024
Henan Provincial People's Hospital
2024
Zhengzhou University
2024
Tongji University
2013-2022
Shanghai Tenth People's Hospital
2016-2022
University of Victoria
2011-2019
Shanghai East Hospital
2015-2017
University of Münster
2004
Acute kidney injury (AKI) is a critical clinical condition that causes fibrosis, and it currently lacks specific treatment options. In this research, we investigate the role of SENP1-Sirt3 signaling pathway its correlation with mitochondrial dysfunction in proximal tubular epithelial cells (PTECs) using folic acid (FA) ischemia-reperfusion-induced (IRI) AKI models. Our findings reveal Sirt3 SUMOylation site mutation (Sirt3 KR) or pharmacological stimulation (metformin) protected mice against...
Abstract Glomerulonephritis is the one of major causes end‐stage kidney disease, whereas pathological process glomerulonephritis still not completely understood. Single‐cell RNA sequencing (scRNA‐seq) emerges to be a powerful tool evaluate full heterogeneity diseases. To reveal cellular gene expression profiles glomerulonephritis, we performed scRNA‐seq 2 human transplantation donor samples, 4 1 malignant hypertension (MH) sample and chronic interstitial nephritis (CIN) sample, all tissues...
Abstract Background Until now, there has been no particularly effective treatment for chronic kidney disease (CKD). Fibrosis is a common pathological change that exist in CKD. Methods To better understand the transcriptional dynamics fibrotic kidney, we make use of single-nucleus assay transposase-accessible chromatin sequencing (snATAC-seq) and single-cell RNA (scRNA-seq) from GEO datasets perform scRNA-seq human biopsy to seek possible transcription factors (TFs) regulating target genes...
Although retinal bipolar cells represent a morphologically well defined population of interneurons, very little is known about the developmental mechanisms that regulate their processing. Furthermore, identity specific cell types function in distinct visual circuits remains poorly understood. Here, we show homeobox gene Vsx1 expressed Type 7 ON cells. In absence Vsx1, exhibit proper morphological specification but defects terminal expression. required for repression cell-specific markers,...
Abstract Transferrin receptor (TFR) is an important iron transporter regulating homeostasis and has long been used as a marker for clathrin mediated endocytosis. However, little known about its additional function other than transport in the development of central nervous system (CNS). Here we demonstrate that TFR functions regulator to control AMPA trafficking efficiency synaptic plasticity. The conditional knockout (KO) neural progenitor cells causes mice develop progressive epileptic...
Interneuronal subtype diversity lies at the heart of distinct molecular properties and synaptic connections that shape formation neuronal circuits are necessary for complex spatial temporal processing sensory information. Here, we investigate role Irx6, a member Iroquois homeodomain transcription factor family, in regulating development retinal bipolar interneurons. Using knock-in reporter approach, show that, mouse retina, Irx6 is expressed type 2 3a OFF interneurons required expression...
Abstract Purpose We investigated the role of farnesoid X receptor (FXR), a ligand‐dependent transcription factor, in renal ischaemia‐reperfusion (I/R) injury. Materials and Methods performed unilateral I/R model FXR knockout ( Fxr −/− ) wild‐type (WT) mice vivo hypoxia‐reoxygenation (H/R) vitro. The pathways by which induces apoptosis were detected using proteome profiler array. effects on evaluated immunoblotting, TUNEL assays flow cytometry. Results Compared with WT mice, showed improved...
Noninvasively predicting kidney tubulointerstitial fibrosis is important because it's closely correlated with the development and prognosis of chronic disease (CKD). Most studies shear wave elastography (SWE) in CKD were limited to non-linear statistical dependencies didn't fully consider variables' interactions. Therefore, support vector machine (SVM) learning was used assess prediction value SWE traditional ultrasound techniques fibrosis.We consecutively recruited 117 patients biopsy. SWE,...
Kidney ischemia and reperfusion injury could cause microvascular barrier dysfunction, lung inflammatory cascades activation, programmed cell death of pulmonary endothelium, leading to acute injury. Our study aimed at determining whether erythropoietin (EPO) can ameliorate dysfunction following renal (IR) explored the underlying mechanisms. In vivo, C57BL/6 mice received EPO (6000 U/kg) before right vascular pedicles clamping for 30 minutes, followed by 24 hours reperfusion. The...
Abstract The Pierre Robin Sequence (PRS), consisting of cleft palate, glossoptosis and micrognathia, is a common human birth defect. However, how this abnormality occurs remains largely unknown. Here we report that neural crest cell (NCC)-specific knockout transferrin receptor (Tfrc), well known transporter protein, caused severe respiratory distress inability to suckle in mice, which highly resemble PRS. Histological anatomical analysis revealed the palate due failure palatal shelves...
(1) Background: Astragaloside IV (AS-IV) is derived from Astragalus membranous (AM), which used to treat kidney disease. Macrophages significantly affect the whole process of renal ischemia-reperfusion (I/R). The regulation macrophage polarization in kidneys by AS-IV was focus. (2) Methods: Renal tubular injury and fibrosis mice were detected Hematoxylin Eosin staining Masson Trichrome Staining, separately. An ELISA quantitative real-time polymerase chain reaction explore cytokine mRNA...
Monitoring allograft function during the early stages is crucial, and therefore requires biomarkers more sensitive than serum creatinine (Scr). Kidney injury molecular-1 (KIM-1) a potent biomarker; however, disparities exist in literature concerning its predictive value function. Therefore, this study aimed to evaluate for long-term prognosis of kidney transplantation patients.A prospective with cohort comprising 160 patients scheduled was conducted power urinary KIM-1 (uKIM-1) other renal...
The heterotrimeric G protein subunit Gsα couples receptors to activate adenylyl cyclase and is required for the intracellular cAMP response kinase A (PKA) activation. ubiquitously expressed in many cell types; however, role of neural crest cells (NCCs) remains unclear. Here we report that NCCs-specific knockout mice die within hours after birth exhibit dramatic craniofacial malformations, including hypoplastic maxilla mandible, cleft palate skeleton defects. Histological anatomical analysis...
During a developmental period that extends postnatally in the mouse, proliferating multipotent retinal progenitor cells produce one of 7 major cell types (rod, cone, bipolar, horizontal, amacrine, ganglion, and Müller glial cells) as they exit cycle consecutive waves. Cell production retina is tightly regulated by intrinsic, extrinsic, spatial, temporal cues, coupled to timing exit. Arsenic-resistance protein 2 (ARS2, also known SRRT) component nuclear cap-binding complex involved RNA...
MicroRNAs (miRNAs) regulate several biological processes, including tumorigenesis. In order to comprehend the roles of miRNAs in cancer, various screens were performed investigate changes expression levels that occur different types cancer. The present review focuses on results five recent screens, whereby a number overlapping identified be downregulated or differentially regulated, whereas no observed frequently upregulated. Furthermore, majority common >1 screen involved signaling...
Background: Shear wave elastography ultrasound (SWE) is an emerging non-invasive candidate for assessing kidney stiffness. However, its prognostic value regarding injury unclear. Methods: A prospective cohort was created from biopsy patients in our hospital May 2019 to June 2020. The primary outcome the initiation of renal replacement therapy or death, while secondary eGFR < 60 mL/min/1.73 m2. Ultrasound, biochemical, and examinations were performed on same day. Radiomics signatures...