A5000011443- Carbon Nanotubes in Composites
- Graphene and Nanomaterials Applications
- Graphene research and applications
- Nanoparticles: synthesis and applications
- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Nanotechnology research and applications
- Fullerene Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- MRI in cancer diagnosis
- Diamond and Carbon-based Materials Research
- Nanoplatforms for cancer theranostics
- Nanopore and Nanochannel Transport Studies
- Central Venous Catheters and Hemodialysis
- Advanced Nanomaterials in Catalysis
- Anesthesia and Neurotoxicity Research
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Adipose Tissue and Metabolism
- Neuroscience and Neural Engineering
- Heme Oxygenase-1 and Carbon Monoxide
- Advanced Neuroimaging Techniques and Applications
- Synthesis and Properties of Aromatic Compounds
Renji Hospital
2006-2025
National Institute of Advanced Industrial Science and Technology
2015-2024
Shanghai Jiao Tong University
2015-2024
Union Hospital
2023
Fujian Medical University
2023
China National Biotechnology (China)
2023
Army Medical University
2020-2023
Southwest Hospital
2020-2023
Jiangmen Central Hospital
2021-2022
Sun Yat-sen University
2021
Contrast-induced acute kidney injury (CI-AKI) occurs in more than 30% of patients after intravenous iodinated contrast media and causes serious complications, including renal failure mortality. Recent research has demonstrated that routine antioxidant alkaline therapy failed to show benefits CI-AKI with high risk for complications. Mitophagy is a mechanism selective autophagy, which controls mitochondrial quality reactive oxygen species (ROS) through degradation damaged mitochondria. The...
The pathogenetic mechanism of contrast-induced acute kidney injury (CI-AKI), which is the third most common cause hospital-acquired AKI, has not been elucidated. Previously, we demonstrated that renal and cell apoptosis were attenuated in nlrp3 knockout CI-AKI mice. Here, investigated underlying NLRP3 inhibition-mediated attenuation CI-AKI. RNA sequencing analysis cortex revealed or casp1 mice exhibited upregulated cellular response to hypoxia, mitochondrial oxidation, autophagy when...
Abstract Single-chirality, single-wall carbon nanotubes are desired due to their inherent physical properties and performance characteristics. Here, we demonstrate a chromatographic separation method based on newly discovered chirality-selective affinity between gel containing mixture of the surfactants. In this system, two different selectivities found: chiral-angle selectivity diameter selectivity. Since chirality is determined by chiral angle diameter, combining these independent leads...
Cisplatin is widely recommended in combination for the treatment of tumors, thus inevitably increasing incidence cisplatin-induced acute kidney injury. Mitophagy a type mitochondrial quality control mechanism that degrades damaged mitochondria and maintains cellular homeostasis. Ferroptosis, new modality programmed cell death, characterized by iron-dependent phospholipid peroxidation oxidative membrane damage. However, role mitophagy ferroptosis disease unclear. Here, we investigated...
Multifunctionalization of carbon nanotubules is easily achieved by attaching functional molecules that provide specific advantages for microscopic applications. We fabricated a double photodynamic therapy (PDT) and photohyperthermia (PHT) cancer phototherapy system uses single laser. Zinc phthalocyanine (ZnPc) was loaded onto single-wall nanohorns with holes opened (SWNHox), the protein bovine serum albumin (BSA) attached to carboxyl groups SWNHox. In this system, ZnPc PDT agent, SWNHox PHT...
Ultrasonication of single-wall carbon nanotubes (SWNTs) in a monochlorobenzene (MCB) solution poly(methyl methacrylate) (PMMA) enabled us to react SWNTs with MCB or PMMA chemically. After the reacted these organic materials, they turned into ragged (r-SWNTs) many defects sidewall when burned oxygen. We think that sonochemical reaction and materials is simple method functionalize SWNTs.
Mitophagy is a principle mechanism to degrade damaged mitochondria through PARK2-dependent or PARK2-independent pathway. has been identified play an important role in acute kidney disease, whereas its renal fibrosis remains ill-defined. We sought investigate the involvement and regulation of mitophagy tubular epithelial cell(RTEC) injury after unilateral ureteral obstruction(UUO). Mitochondrial damageand mitochondrial reactive oxygen species (ROS) production was increased obstruction left...
Abstract Chronic kidney disease affects approximately 14.3% of people worldwide. Tubulointerstitial fibrosis is the final stage almost all progressive CKD. To date, pathogenesis renal remains unclear, and there a lack effective treatments, leading to replacement therapy. Mitophagy type selective autophagy that has been recognized as an important way remove dysfunctional mitochondria abrogate excessive accumulation mitochondrial-derived reactive oxygen species (ROS) balance function cells....
We show that light-assisted oxidation with hydrogen peroxide effectively and rapidly opens holes in carbon nanohorn walls and, more importantly, creates abundant oxygenated groups such as carboxylic at the hole edges. These reacted protein bovine serum albumin. The obtained conjugates were highly dispersed phosphate-buffered saline taken up by cultured mammalian cells via an endocytosis pathway.
Although chemical functionalization at carboxyl groups of nanocarbons has been vigorously investigated and the identities quantities have well studied, location had not previously clarified. Here, we show that site identification is possible by using Pt-ammine complex as a stain. After complexes were mixed with graphenes in ethanol, many clusters an average size about 0.6 nm found to exist edges graphene sheets, indicating mainly existed edges. These results will make it easier add...
Abstract Near-infrared photoluminescent single-walled carbon nanotubes (CNTs) are expected to provide effectual bio-imaging tools, although, as yet, only limited applications have been reported. Here, we report that CNTs coated with an amphiphilic and biocompatible polymer, poly(2-methacryloyloxyethyl phosphorylcholine- co - n -butyl methacrylate; PMB), generate high-quality images of brown fat. Brown fat is a heat-productive adipose tissue, which attracting increasing attention new...
Background Several studies have suggested that urgent-start peritoneal dialysis (PD) is a feasible alternative to hemodialysis (HD) in patients with end-stage renal disease (ESRD), but the impact of modality on outcome, especially short-term complications, has not been directly evaluated. The aim current study was compare complications and outcomes PD HD ESRD patients. Methods In this retrospective study, who initiated urgently without pre-established functional vascular access or catheter...
Abstract Iodinated contrast media serves as a direct causative factor of acute kidney injury (AKI) and is involved in the progression cellular dysfunction apoptosis. Emerging evidence indicates that NLRP3 inflammasome triggers inflammation, apoptosis tissue during AKI. Nevertheless, underlying renoprotection mechanism against contrast-induced AKI (CI-AKI) was still uncertain. This study investigated role CI-AKI both vitro vivo . In HK-2 cells unilateral nephrectomy model, member ASC were...
Carbon nanotubes (CNTs) are considered to be among the most promising materials of 21st century due their electronic, optical, mechanical, and thermodynamic properties. As projected use CNTs has increased in a variety fields, including nanoelectronics, energy, science, biology, long-term toxicity attracted increasing concern. This issue is especially important because extremely physically chemically stable, therefore may not biodegradable. However, novel approaches for degrading have been...
Marein, an active component of the Coreopsis tinctoria Nutt. plant, is known to improve diabetic nephropathy (DN). However, its anti-diabetic functions in DN and potential mechanisms remain unclear. The aim this study was elucidate effects Marein db/db mice with DN, high glucose–treated HK-2 cells. In vivo, treating for 12 consecutive weeks restored diabetes-induced hyperglycemia dyslipidemia, ameliorated renal function deterioration, glomerulosclerosis, ectopic lipid deposition. exerted...
A new noncovalent and nonorganic method has been utilized in dispersing single-walled carbon nanotubes (SWNTs) water, up to single tube level. SWNTs, otherwise flocculated aqueous solutions, were stabilized through the addition of highly charged nanoparticles. The dispersed SWNTs could be self-assembled into macroscopic materials solutions by application external stimuli. By anchoring solution onto pyrene-modified Si/SiO2 surfaces, discrete, individual have observed atomic force microscopy...
Kidney injury molecule-1 (KIM-1) is highly expressed in renal tubular cells after and usually regarded as an early biomarker of acute kidney injury(AKI). The aim this study was to determine the role KIM-1 development Methods: Clinical samples, three different animal models vitro experiments were utilized possible mechanism underlying involvement injury.Both plasma urinary expression levels significantly higher AKI chronic disease (CKD) patients than healthy volunteers, CKD patients....
With the rapid developments in medical applications of carbon nanomaterials such as nanohorns (CNHs), nanotubes, and graphene based nanomaterials, understanding long-term fate, health impact, excretion, degradation these materials has become crucial. Herein, vitro biodegradation CNHs was determined using a non-cellular enzymatic oxidation method two types macrophage cell lines. Approximately 60% degraded within 24 h phosphate buffer solution containing myeloperoxidase. Furthermore,...
Introduction and objective: With the increase in carbon nanotube-based products on commercial market, public concern regarding possible toxicity of these nanomaterials has attracted much attention. Although previous studies found no obvious related to nanotubes (CNTs), their safety not been established because long-term evaluation is still needed. In vitro assays are used understand nanomaterials. However, data published so far were generated short-term which cells continuously exposed CNTs....