A5101851230- Liver Disease Diagnosis and Treatment
- Membrane Separation Technologies
- Sulfur-Based Synthesis Techniques
- Epigenetics and DNA Methylation
- Hepatitis B Virus Studies
- RNA modifications and cancer
- Synthesis and Catalytic Reactions
- Synthesis and Biological Evaluation
- Radical Photochemical Reactions
- Cell Adhesion Molecules Research
- Catalytic C–H Functionalization Methods
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Wastewater Treatment and Nitrogen Removal
- Hepatitis C virus research
- Chemokine receptors and signaling
- Pharmaceutical and Antibiotic Environmental Impacts
- Organ Transplantation Techniques and Outcomes
- Membrane-based Ion Separation Techniques
- Liver physiology and pathology
- Cancer, Lipids, and Metabolism
- Water Quality Monitoring and Analysis
- Chemical Synthesis and Reactions
- Quantum Information and Cryptography
Shandong Jianzhu University
2025
Ningxia Medical University
2023-2025
Shandong University
2011-2024
University of Jinan
2024
Shuozhou Central Hospital
2024
Shandong First Medical University
2020-2024
Shandong Provincial Hospital
2017-2024
Beijing University of Posts and Telecommunications
2021-2024
Shandong University of Traditional Chinese Medicine
2024
Zero to Three
2023
Interleukin-8 (IL-8) plays a vital role in the invasion and metastasis of hepatocellular carcinoma (HCC), is closely associated with poor prognosis HCC patients. Integrin αvβ3, member integrin family, has been reported to be overexpressed cancer tissues mediate cells. However, relationship between IL-8 αvβ3 underlying mechanism remains unclear.The expression IL-8, αv β3 cells was detected by quantitative real-time PCR, Western blot immunohistochemistry. Transwell assay used detect...
Sulfonamide antibiotics (SMs) and heavy metals, simultaneously existing in swine wastewater, threat ecological security public health. Anaerobic dynamic membrane bioreactor (AnDMBR) technology has shown great potential for excellent cost-effective treatment of various types industrial wastewaters. Herein, it was the first time applied treating wastewater containing both SMs with particular efforts devoted to understanding fate metals their effect on (DM) fouling. The AnDMBR exhibited...
An efficient one-step protocol has been developed to access a variety of 2-amino-1,3-benzoxazine derivatives via tetrabutylammonium iodide-mediated electrochemical desulfurative cyclization isothiocyanates and 2-aminobenzyl alcohols. The reaction proceeds through cycle involving in situ iodine generation, cyclization, iodide regeneration, efficiently forming intermolecular C–O C–N bonds affording 2-amino-1,3-benzoxazines moderate excellent yields. practical utility this strategy is evidenced...
A convenient methodology for the synthesis of benzo[c]naphthyridinone derivatives was developed via Rh(III)-catalyzed and Cu(I)-oxidized annulation 3-diazooxindoles with 3-aryl-5-isoxazolones. This transformation involves in situ generation tricyclic core through...
The present study screened potential genes related to lung adenocarcinoma, with the aim of further understanding disease pathogenesis. GSE2514 dataset including 20 adenocarcinoma and 19 adjacent normal tissue samples from 10 patients aged 45-73 years was downloaded Gene Expression Omnibus. Differentially expressed (DEGs) between two groups were using t-test. Potential gene functions predicted functional pathway enrichment analysis, protein-protein interaction (PPI) networks obtained STRING...
The metastatic potential of colorectal cancer (CRC) is intensively promoted by the tumor microenvironment (TME) in a paracrine manner. As pleiotropic inflammatory cytokine, Interleukin-6 (IL-6) produced and involved CRC, same scenario where integrin α v β 6 also becomes upregulated. However, relationship between IL-6 as well their involvement crosstalk CRC TME remains largely unclear. In present study, we demonstrated positive correlation expression samples. mutually promotive interaction...
Methylation of gene promoter CpG islands is an important early event in hepatocellular carcinoma (HCC), and detection cell‐free tumor‐specific DNA methylation becoming a useful noninvasive method for HCC. This study was aimed at determining the diagnostic value serum insulin‐like growth factor‐binding protein 7 ( IGFBP7 ) hepatitis B virus‐associated A total 217 subjects, including 136 HCC patients, 46 patients with chronic (CHB), 35 healthy controls (HCs), were included. The status...
BACKGROUND Hepatocellular carcinoma (HCC) is the sixth most common type of cancer and fourth leading cause cancer-related death worldwide. Sarcomatoid HCC, which contains poorly differentiated carcinomatous sarcomatous components, a rare histological subtype HCC that differs from conventional HCC. It highly aggressive has poor prognosis. Its clinicopathological characteristics, surgical outcomes underlying mechanisms its nature have not been fully elucidated. AIM To examine characteristics...
Several studies have revealed that MFG-E8 (milk fat globule–epidermal growth factor 8) is related to tumour development and progression. However, the relationship between expression metastasis in colorectal cancer patients role of invasion progression remain unknown. In this study, we performed immunohistochemistry quantitative real-time polymerase chain reaction assess adjacent non-cancerous tissues. Colorectal RNAseq data from The Cancer Genome Atlas project were downloaded was analysed....
Abstract Background and Aim Methylation of tissue factor pathway inhibitor 2 (TFPI2) gene has been detected in hepatocellular carcinoma (HCC). However, the clinicopathologcial significance prognostic value TFPI2 methylation HCC remains largely unknown. This study aimed to investigate after hepatectomy. Methods status was examined 178 surgical specimens 20 normal liver samples using methylation‐specific polymerase chain reaction. Results 44.9% (80 178) primary samples, 10.7% (19 corresponding...
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. Epigenetic analysis has attracted increasing attention in molecular diagnosis HCC. Cysteine dioxygenase 1 (CDO1) a key enzyme taurine biosynthetic pathway and converts cysteine to sulfinate. The CDO1 gene tumor suppressor usually silenced by methylation its promoter carcinogenesis. In this study, we evaluated whether status diagnostic value for hepatitis B virus (HBV)-related was determined serum...
Hepatocellular carcinoma (HCC) is a liver disease with complex underlying mechanism, and patients HCC have low survival rates. Iron metabolism plays crucial role in the pathogenesis of HCC; however, prognostic value iron metabolism-related methylated genes for needs to be further explored. In present study, we identified differentially expressed (DEGs) that play DNA methylation from The Cancer Genome Atlas. Four these DEGs, whose expression levels are correlated prognosis, namely, RRM2,...
Abstract Liver fibrosis is caused by chronic liver injury. There are limited treatments for it, and the pathogenesis unclear. Therefore, there an urgent need to explore of fibrosis, try identify new potential therapeutic targets. For this study we used carbon tetrachloride abdominal injection induced animal model in mice. Primary hepatic stellate cell isolation was performed a density‐gradient separation method, followed immunofluorescence stain analyses. Signal pathway analysis...
An efficient method was developed for the one-pot construction of pyrrolo[1,2- a ]quinoxalines via Cu( ii )-catalyzed domino reaction between 2-(1 H -pyrrol-1-yl)anilines and alkylsilyl peroxides.
Effective biomarkers are needed to predict the efficacy of immune checkpoint inhibitors (ICIs) therapy in hepatocellular carcinoma (HCC). We evaluated early changes serum interleukin-8 (IL-8) levels as a biomarker response ICIs patients with unresectable HCC.
Promoter methylation of tumor suppressor gene SOX11 has been reported to contribute the diagnosis and prognosis various cancerous diseases, including gastric cancer, hematopoietic malignancies nasopharyngeal carcinoma.However, there is no data on diagnostic potential serum promoter in hepatocellular carcinoma (HCC).This study was therefore aimed investigate role as a noninvasive biomarker patients with hepatitis B virus (HBV) associated HCC.A total 205 subjects were retrospectively included,...
Abstract Background and Aim Liver biopsy remains the gold standard to evaluate liver histology. However, it has several limitations. This study aims construct a noninvasive model predict histology for commencing antiviral therapy in HBeAg‐positive chronic hepatitis B (CHB) with aminotransferase (ALT) ≤ 2 upper limit of normal (ULN). Methods Two hundred ninety‐eight patients CHB, ALT 2ULN HBV‐DNA ≥20 000 IU/ml were enrolled randomly divided into training group validation group. A was...