A5100323892- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Microbial Natural Products and Biosynthesis
- Phagocytosis and Immune Regulation
- Glioma Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Cancer Research and Treatments
- Immune cells in cancer
- Central Venous Catheters and Hemodialysis
- Global Cancer Incidence and Screening
- Renal cell carcinoma treatment
- PARP inhibition in cancer therapy
- Fungal Infections and Studies
- Cardiac electrophysiology and arrhythmias
- Pressure Ulcer Prevention and Management
- Surgical site infection prevention
- Bariatric Surgery and Outcomes
Nanjing Medical University
2017-2025
Jiangsu Province Hospital
2017-2025
Dalian Medical University
2024
Second Affiliated Hospital of Dalian Medical University
2024
Beijing Shijitan Hospital
2024
Capital Medical University
2024
Huazhong University of Science and Technology
2024
Tongji Hospital
2024
Chinese Research Academy of Environmental Sciences
2024
Union Hospital
2024
Interleukin-8 (IL-8) plays a vital role in the invasion and metastasis of hepatocellular carcinoma (HCC), is closely associated with poor prognosis HCC patients. Integrin αvβ3, member integrin family, has been reported to be overexpressed cancer tissues mediate cells. However, relationship between IL-8 αvβ3 underlying mechanism remains unclear.The expression IL-8, αv β3 cells was detected by quantitative real-time PCR, Western blot immunohistochemistry. Transwell assay used detect...
<h3>Importance</h3> A higher incidence of pancreatic cancer has been reported in the Chinese population compared with White population, but genetic differences are unknown to date. Large-sample germline testing for both familial and sporadic cancers conducted predominantly populations, whereas similar studies populations limited. <h3>Objective</h3> To assess prevalence sequence variations patients diseases China. <h3>Design, Setting, Participants</h3> This association study was a case series...
This study aims to integrate pancreatic cancer TCGA, GEO, and single-cell RNA-sequencing (scRNA-seq) datasets, explore the potential prognostic markers underlying mechanisms of immune microenvironment through bioinformatics methods, in vitro vivo assays.Expression data clinicopathological GEO (GSE131050), single cell sequencing (PAAD_CRA001160) dataset were downloaded. We used R/Bioconductor edgeR for differential expression analysis. ClusterProfiler was utilized perform GO enrichment...
Several studies have revealed that MFG-E8 (milk fat globule–epidermal growth factor 8) is related to tumour development and progression. However, the relationship between expression metastasis in colorectal cancer patients role of invasion progression remain unknown. In this study, we performed immunohistochemistry quantitative real-time polymerase chain reaction assess adjacent non-cancerous tissues. Colorectal RNAseq data from The Cancer Genome Atlas project were downloaded was analysed....
Diffusion tensor imaging (DTI) measures the displacement of water molecules across tissue components and thus provides information on microstructure brain white matter. This study examined effect Tai Chi relation experiences skills with Fractional anisotropy (FA) was obtained from DTI magnetic resonance images two group participants, namely, long-term practitioners sedentary counterparts. Whole-brain voxel-based analysis showed that had higher FA in splenium corpus callosum (p = 0.015) than...
Abstract Background At present, the treatment of recurrent glioblastoma is extremely challenging. In this study, we used a novel three-dimensional non-coplanar template (3DNPT) combined with open MR to guide 125 I seed implantation for glioblastoma. The aim study was evaluate feasibility, accuracy, and effectiveness technique. Methods Twenty-four patients underwent 3DNPT MR-guided brachytherapy from August 2017 January 2019. Preoperative plan were made according enhanced isovoxel T1-weighted...
Central pancreatectomy (CP) has been applied for treating benign and low-grade malignant tumors in pancreatic neck, but studies regarding CP ductal adenocarcinoma (PDAC) are quite limited. We aimed to investigate the role of central treatment PDAC neck pancreas.Patients who underwent at our hospital between 2009 2016 were identified. Patients treated by distal (DP) matched according tumor size, location, staging. The surgical survival outcomes compared DP groups.Nine patients had CP. Five...
To investigate the safety and efficacy of TRIANGLE operation after neoadjuvant chemotherapy in locally advanced pancreatic cancer(LAPC).
Background: Postoperative pancreatic fistula (POPF) is the major complication following pancreaticoduodenectomy (PD). We sought to develop and validate a risk prediction model for POPF after PD with aim of determining personal probability proposing novel strategy intraoperative placement and/or early-removal prophylactic drainage. Methods: Data from 993 patients undergoing January 2012 December 2016 were retrospectively analyzed. Patients randomly assigned either training cohort or...
Abstract There have been few studies comparing percutaneous transhepatic variceal embolization (PTVE) and transjugular intrahepatic portosystemic shunt (TIPS) for the prevention of recurrent gastric bleeding (GVB). Compare outcomes these 2 procedures in patients with GVB. A total 74 cirrhosis GVB who underwent TIPS modified PTVE were enrolled. The rebleeding mortality rates, portal vein pressure (PVP) variation, rates hepatic encephalopathy (HE) compared between groups. 43 31 enrolled this...
To construct functional human full-thickness corneal replacements.Acellular porcine matrix (APCM) was developed from cornea by decellulariztion. The biomechanical properties of anterior-APCM (AAPCM) and posterior-APCM (PAPCM) were checked using uniaxial tensile testing. Human cells obtained cell culture. Suspending ring designed deformation an acupuncture needle. MTT cytotoxicity assay used to check the suspending soaking solutions. A new three-dimensional organ culture system established...
Objective Pancreatic adenocarcinoma (PAAD) is one of the most lethal malignant tumors worldwide. Various studies based on cell lines, preclinical mouse models, and human tissue samples have shown that cycle-associated proteins are involved in tumorigenesis progression PAAD. Methods Herein, we analyzed relationships between CDK1 CCNA2 gene expression prognosis patients with pancreatic cancer, using information from Oncomine, cBioportal, Kaplan–Meier Plotter, GEPIA databases. Results...
Background Despite the advancements in surgical techniques, postoperative pancreatic fistula (POPF) remains a potentially life-threatening complication of pancreaticoduodenectomy (PD). Pancreatic duct occlusion (PDO) without anastomosis has also been proposed to alleviate clinical consequences POPF selected patients after PD. Objectives To assess safety and effectiveness PDO with mechanical closure PD an atrophic body-tail small duct. Methods We retrospectively identified two female male...
Pancreatic cancer (PC) is a malignant tumor with extremely poor prognosis, exhibiting resistance to chemotherapy and immunotherapy. Nowadays, it ranked as the third leading cause of cancer-related mortality. Glycation common epigenetic modification that occurs during transformation. Many studies have demonstrated strong correlation between glycation progression. However, expression status glycosylation-related genes (GRGs) in PC their potential roles microenvironment not been extensively...
Objective To explore the safety and feasibility of radical antegrade modular pancreato-splenectomy (RAMPS) for carcinoma pancreatic body tail (CPBT). Methods The retrospective cohort study was adopted. The clinical data 99 patients with CPBT who were admitted to First Affiliated Hospital Nanjing Medical University from January 2013 October 2015 collected. Among patients, 21 receiving RAMPS allocated into group 78 traditional resection pancreas splenectomy operation group. Observation...