A5090316810- Carbon and Quantum Dots Applications
- Nanocluster Synthesis and Applications
- Histone Deacetylase Inhibitors Research
- Advanced Nanomaterials in Catalysis
- Click Chemistry and Applications
- Cancer Immunotherapy and Biomarkers
- Medical Imaging Techniques and Applications
- Lung Cancer Treatments and Mutations
- Metal complexes synthesis and properties
- Protein Degradation and Inhibitors
- Head and Neck Cancer Studies
- Chronic Lymphocytic Leukemia Research
- Advanced biosensing and bioanalysis techniques
- Biochemical effects in animals
- Sulfur Compounds in Biology
- Iron Metabolism and Disorders
- Electrochemical sensors and biosensors
- Antimicrobial agents and applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chronic Myeloid Leukemia Treatments
- Burkholderia infections and melioidosis
- Acupuncture Treatment Research Studies
- Potassium and Related Disorders
- Mercury impact and mitigation studies
- Venous Thromboembolism Diagnosis and Management
Xian Yang Central Hospital
2023
Shandong University
2016-2022
Shandong Provincial Hospital
2016-2021
United States Department of Veterans Affairs
1990
Hill, T. C.; Holman, B. I.; Ovett, R. O Leary, D. H.; Front, D.; Magistretti, P.; Zimmerman, E.; Moore, S.; Clouse, M. Wu, J. L.; Lin, H; Baldwin,
We report a case of Pseudomonas pseudomallei infection, in which the patient acquired bacteria by aspiration river water after drowning incident near Manila, Philippines. The pulmonary form melioidosis was noted at onset, but septicemia developed later stage. Positive blood cultures were obtained 17 days accident. treated successfully with combination amikacin and cephalothin. This is first P. infection documented Taiwan.
Background: Tigecycline was recently found to cause coagulation disorders, especially hypofibrinogenemia, which may interfere with the administration of antimicrobial therapy. This study aimed investigate incidence and clinical characteristics risk factors for tigecycline-associated hypofibrinogenemia. Methods: In this multicenter retrospective study, patients receiving tigecycline or imipenem–cilastatin treat Gram-negative bacterial infections in nine Chinese tertiary hospitals between...
Chest CT images were acquired in a 67-year-old man to evaluate left lung mass revealed by chest radiography. The image findings suggested possible pulmonary malignancy. FDG PET/CT was performed for staging, which showed the abnormally increased activity with hypermetabolic lymph node. Pathology from biopsy confirmed malignant perivascular epithelioid cell tumor.
Histone deacetylases (HDACs) are a class of enzymes that responsible for the removal acetyl groups from ε-N-acetyl lysine histones, allowing histones to wrap DNA more tightly. HDACs play an essential role in many biological processes, such as gene regulation, transcription, cell proliferation, angiogenesis, migration, differentiation and metastasis, which make it excellent target anticancer drug discovery. The search histone deacetylase inhibitors (HDACis) has been intensified, with numerous...
Osteoid osteoma is an uncommon benign tumor of bone that rarely involves the cranium. It often causes local pain worse at night, characteristically relieved by aspirin, and does not correlate with size lesion. The diagnosis depends on skull radiographs computed tomography. This report describes a case in which showed nothing abnormal. operative localization were accomplished radionuclide scanning. Thus, possibility radiographically cryptic lesions must be considered evaluation atypical head...
Tumor growth and metastasis are caused by many factors. The complexity means that a multi-target combination therapy strategy should be selected against tumor metastasis. Here, cisplatin (CDDP) bendazac (Ben) were designed as novel NSAID-Pt(IV) nanoplatform, which is an effective weapon for combating
Inhibition of histone deacetylases (HDACs) has proven to be an effective strategy for cancer therapy. To date, five deacetylase inhibitors (HDACis) have been approved treatment, and numerous others are undergoing clinical trials. An agent that can simultaneously effectively inhibit two or more targets may offer greater therapeutic benefits over single-acting agents in preventing resistance treatment potentiating synergistic effects. A prime example a bifunctional is the hybrid HDACi....
The resistance of C. albicans to traditional antifungal drugs brings a great challenge clinical treatment. To overcome the resistance, developing agent sensitizers has attracted considerable attention. This study aimed determine anti-Candida activity BEH alone or BEH-FLC combination and explore underlying mechanisms.In vitro effects were performed by broth microdilution assay XTT reduction assay. Infected Galleria mellonella larvae model was used in vivo. Probes Fluo-3/AM, FITC-VAD-FMK...
Abstract Background Programmed cell death protein 1 (PD-1) monoclonal antibody, pembrolizumab, is a promising drug for platinum-pretreated, recurrent or metastatic nasopharyngeal cancer (NPC). We aimed to assess the cost-effectiveness of pembrolizumab compared with chemotherapy Chinese patients in this NPC. Methods The versus was evaluated using partitioned survival model 5-year boundary. Efficacy and toxicity data were derived from KEYNOTE-122 trials. Economic indicators including...
AbstractFerric ion (Fe3+) serves as an essential and indispensable inorganic element in various biological process. Excess Fe3+ is harmful for systems human health. Herein, highly sensitive carbon quantum dots (Fe-CQDs) ferric ions were synthesized by a high-efficiency, one-step hydrothermal route utilizing L-arginine citric acid. The prepared Fe-CQDs exhibited good water solubility, high photostability, bright blue florescence with relatively yields (QYs) over 21.33% Stokes shift exceeding...
Our purpose was to establish a simple and feasible method for monitoring controlling the Tc-Technegas inhaled improve success ratio of imaging ensure quality.The relationship between pulmonary ventilation counting rate (VCR) 113 cases, activity perfusion agents injected (PCR) another 114 cases were analysed retrospectively. And combined with surface radioactivity value SPECT probe model, effective range VCR determined. Two hundred fifty monitored controlled used verify reliability...