A5063476562- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Renal cell carcinoma treatment
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Gallbladder and Bile Duct Disorders
- Kruppel-like factors research
- Galectins and Cancer Biology
- Cancer Mechanisms and Therapy
- Gastrointestinal disorders and treatments
- Epigenetics and DNA Methylation
- Gastric Cancer Management and Outcomes
- Pharmaceutical and Antibiotic Environmental Impacts
- Cancer-related Molecular Pathways
- Renal and related cancers
- Phagocytosis and Immune Regulation
- Anorectal Disease Treatments and Outcomes
- TGF-β signaling in diseases
- Hedgehog Signaling Pathway Studies
- FOXO transcription factor regulation
Nanjing Medical University
2014-2023
University Hospital Heidelberg
2023
Heidelberg University
2023
Jiangsu Province Hospital
2012-2023
Abstract Background A growing number of studies have focused on investigating circRNAs as crucial regulators in the progression multiple cancer types. Nevertheless, biological effects and underlying mechanisms pancreatic ductal adenocarcinoma (PDAC) remain unclear. Methods Differentially expressed between cancerous tissue adjacent normal tissues were identified by RNA sequencing PDAC. Subsequently, vitro vivo functional experiments performed to investigate roles circNEIL3 PDAC tumour growth...
Long non-coding RNAs (lncRNAs) play an important role in the development and progression of various tumors, including pancreatic cancer (PC). Recent studies have shown that lncRNAs can 'act cis' to regulate expression its neighboring genes. Previously, we used microarray identify a novel lncRNA termed XLOC_000647 was down-regulated PC tissues. However, function remain unclear. The NLRP3 specimens cell lines were detected by quantitative real-time PCR. Transwell assays determine migration...
Pancreatic adenocarcinoma (PDAC) and chronic pancreatitis (CP) are characterized by a desmoplastic reaction involving activated pancreatic stellate cells (PSCs). However, the mechanisms of PSC activation remain poorly understood. We examined whether epithelial-mesenchymal transition (EMT) process might play role in activation. PSCs were isolated from rat pancreas using immunofluorescence immunocytochemistry. evaluated changes cell motility expression levels panel EMT-related genes during...
Long noncoding BRAF-activated RNA has been reported to be tightly associated with tumorigenesis and development in various types of cancers. However, the expression, biological function, modulatory mechanism pancreatic cancer remained unclear. In present work, we explored carcinogenic activity underlying on vitro. We identified that was upregulated tissues cell lines, related tumor metastasis stage. reinforces proliferation, invasion, migration PANC-1 SW1990 cells. Moreover, miR-195-5p...
Vasohibin‑2 (VASH2) is an angiogenic factor, and has been previously reported to be a cancer‑related gene, with cytoplasmic karyotypic forms. In the current study VASH2 expression in human breast cancer tissue adjacent non‑cancerous was investigated immunohistochemistry. MCF‑7 BT474 cells were transfected lentiviral constructs generate vitro overexpression knockdown models. addition, BALB/cA nude mice inoculated subcutaneously vivo models of knockdown. The effect on cell proliferation using...
Summary The treatment elements used for pancreatic ductal adenocarcinoma (PDAC) include surgical resection, systemic cytotoxic agents, and targeted drugs. For second- third-line therapies in PDAC, approximately 15% of patients have actionable mutations although only 2.5% receive matched but with a significant improvement survival around 16 months. the majority PDAC current most effective strategy is resection primary tumor combination chemotherapy. chemotherapy regimens order delivery...
Objective This review focuses on the state-of-the-art of CXCL12/CXCR4 signaling axis in pancreatic cancer and its role tumor progression. Data sources Relevant articles published English were identified by searching Pubmed from 1997 to 2013, with keywords “CXCL12”, “CXCR4” “pancreatic cancer”. Important references selected also retrieved. Study selection Articles about relevant mechanisms selected. Results Pancreatic has been one most lethal human malignancies, median survival less than year...
Long non-coding RNAs (LncRNAs) have crucial function in epithelial-mesenchymal transition (EMT) pancreatic cancer. It is necessary to comprehensively analyze the potential role of EMT-related lncRNA In present study, genomic data cancer from TCGA database were downloaded and we found 368 lncRNAs. According expression characteristics prognostic-related lncRNAs, all samples could be divided into two clusters with different clinical outcomes tumor microenvironments. Moreover, an eleven lncRNAs...
Abstract A novel antisense lncRNA NT5E was identified in a previous microarray that clearly up‐regulated pancreatic cancer (PC) tissues. However, its biological function remains unclear. Thus, we aimed to explore and clinical significance PC. The lncNT5E expression determined PC specimens cell lines. In vitro vivo studies detected the impact of depletion on proliferation, migration invasion. Western blotting investigated epithelial‐mesenchymal transition (EMT) markers. interaction between...
Background: Undifferentiated carcinoma of pancreas with osteoclast-like giant cells is an extremely rare tumor in pancreas.It relatively difficult to have preoperative diagnosis due the lack specific markers and pre-operative images.Methods: In present study, database center First Affiliated Hospital Nanjing Medical University was retrospectively screened.A total thirteen cases diagnosed as undifferentiated were included.Their clinical data treatments collected.Results: Thirteen patients...
Vasohibin-2 was recently identified as an important pro-angiogenesis factor in solid tumor and intracellular localization of its variants is for elucidating the downstream mechanism(s) effects. Currently there are no reported antibodies affordable localization. The aim this study to generate characterize polyclonal against determine Vasohibin-2. In study, two polypeptides were synthesized one prokaryotic recombinant protein custom-made. New Zealand rabbits immunized with polypeptide mixture...
Background Despite the advancements in surgical techniques, postoperative pancreatic fistula (POPF) remains a potentially life-threatening complication of pancreaticoduodenectomy (PD). Pancreatic duct occlusion (PDO) without anastomosis has also been proposed to alleviate clinical consequences POPF selected patients after PD. Objectives To assess safety and effectiveness PDO with mechanical closure PD an atrophic body-tail small duct. Methods We retrospectively identified two female male...
DUOX2 has been reported to highly express in several types of cancers. However, the prognostic significance and biological function expression with pancreatic cancer (PC) still remain unclear. The present study is aimed at investigating whether could act as a novel biomarker prognosis evaluating its effect on PC cell progression. mRNA protein cells tissues were assessed by quantitative real-time PCR (RT-qPCR) immunohistochemistry. motility proliferation was evaluated vitro. correlation...