A5084853102- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Proteoglycans and glycosaminoglycans research
- Regulation of Appetite and Obesity
- Ovarian function and disorders
- Metabolism, Diabetes, and Cancer
- Lipid metabolism and disorders
- Thyroid Disorders and Treatments
- Endoplasmic Reticulum Stress and Disease
- Glycosylation and Glycoproteins Research
- Vitamin D Research Studies
- DNA Repair Mechanisms
- Fibroblast Growth Factor Research
- Diabetes Treatment and Management
- Cancer therapeutics and mechanisms
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Asthma and respiratory diseases
- Cancer-related molecular mechanisms research
- SARS-CoV-2 and COVID-19 Research
- Biochemical Analysis and Sensing Techniques
- Wnt/β-catenin signaling in development and cancer
- Lymphoma Diagnosis and Treatment
- Gestational Diabetes Research and Management
- Cancer, Lipids, and Metabolism
Dalian Medical University
2016-2025
Chongqing Medical University
2016-2025
Second Affiliated Hospital of Chongqing Medical University
2016-2025
Southeast University
2009-2024
Zhongshan Hospital
2024
Sixth Affiliated Hospital of Kunming Medical University
2024
Kunming Medical University
2024
Sanofi (China)
2021-2023
Zhengzhou University
2022
Weatherford College
2021
Insights from cell cycle research have led to the hypothesis that tumors may be selectively sensitized DNA-damaging agents resulting in improved antitumor activity and a wider therapeutic margin. The theory relies on observation majority of are deficient G1-DNA damage checkpoint pathway reliance S G2 checkpoints for DNA repair survival. regulated by kinase 1, serine/threonine is activated response damage; thus, inhibition 1 signaling impairs increases tumor death. Normal tissues, however,...
Mounting evidence suggests that epitranscriptional modifications regulate multiple cellular processes. N6-Methyladenosine (m6A), the most abundant reversible methylation of mRNA, has critical roles in cancer pathogenesis. However, mechanisms and functions long non-coding RNA (lncRNA) remain unclear. Pancreatic resulted 411,600 deaths globally 2015. By time pancreatic diagnosis, metastasis often occurred other parts body. The present study sought to investigate lncRNA m6A modification its...
Heparan sulfate glycosaminoglycans, present at the cell surface and in extracellular matrix that surrounds cells, are important mediators of complex biological processes. Furthermore, it is now apparent cells dynamically regulate structure their heparan “coat” to differentially signals. In study, importance sequence information contained within tumor cell-surface was investigated. Herein, we demonstrate glycosaminoglycan coat on contains bioactive sequences impinge tumor-cell growth...
In this letter, we report the competing growth of a Pd shell on {110} and {100} facets Au nanorods (Au NRs). This results in disappearance unstable formation rectangularly shaped Pd/Au bimetallic that show only four stable side surfaces. The energy minimization to more morphology is believed be driving force for rectangular shape shell.
Secreted frizzled-related protein-5 (Sfrp5) is a novel adipocyte-secreted hormone that has been shown to link obesity with diabetes. Studies in mice have revealed Sfrp5 represents potential target for the control of obesity-linked abnormalities glucose homeostasis. Our objective was gain insight into physiological role circulating humans. We conducted series cross-sectional and interventional studies general population outpatients Internal Medicine Department at Second Affiliated Hospital,...
Polycystic ovary syndrome (PCOS) is an insulin resistance (IR) state, like obesity and type 2 diabetes mellitus (T2DM). Although previous studies have suggested a correlation between irisin the metabolic parameters associated with T2DM, results been inconsistent. Our objective was to (1) determine circulating levels in women PCOS control subjects, (2) examine relationship of conventional markers resistance, (3) changes interventions modulating IR women. This study comprised series...
Previous cross-sectional studies have established that circulating osteoprotegerin (OPG) levels are associated with nonalcoholic fatty liver disease (NAFLD). However, the role of OPG in metabolic diseases, such as diabetes and NAFLD, is still unclear. In current study, we demonstrated hepatic expression was downregulated NAFLD individuals obese mice. deficiency decreased lipid accumulation CD36 peroxisome proliferator-activated receptor-γ (PPAR-γ) livers OPG-/- mice cultured cells,...
Children with moderate-to-severe asthma continue to have disease complications despite the receipt of standard-of-care therapy. The monoclonal antibody dupilumab has been approved for treatment adults and adolescents as well other type 2 inflammatory diseases.
OBJECTIVE Zinc-α2-glycoprotein (ZAG) has been proposed to play a role in the pathogenesis of insulin resistance. Previous studies humans and rodents have produced conflicting results regarding link between ZAG The objective this study was examine relationships resistance cross-sectional interventional studies. RESEARCH DESIGN AND METHODS Serum (determined with ELISA) compared various parameters related subjects normal glucose tolerance, impaired tolerance (IGT), newly diagnosed type 2...
Long non-coding RNAs (lncRNAs) play an important role in the development and progression of various tumors, including pancreatic cancer (PC). Recent studies have shown that lncRNAs can 'act cis' to regulate expression its neighboring genes. Previously, we used microarray identify a novel lncRNA termed XLOC_000647 was down-regulated PC tissues. However, function remain unclear. The NLRP3 specimens cell lines were detected by quantitative real-time PCR. Transwell assays determine migration...
Pancreatic ductal adenocarcinoma (PDAC) is one of the malignant lethal tumors. It has been reported that transcriptional regulator Yin Yang-1 (YY1) suppressed invasion and metastasis PDAC. However, function YY1 on proliferation migration pancreatic cancer remains to be clarified. In this study, we found overexpression or knockdown can inhibit promote cells. Digital gene expression sequencing indicates cyclin-dependent kinase inhibitor 3 (CDKN3) may candidate target YY1. Then downregulate...
Diabetic nephropathy (DN) is regarded as the leading cause of end-stage renal disease worldwide and lacks novel therapeutic targets. To screen verify special biomarkers for glomerular injury in patients with DN, fifteen datasets were retrieved from Gene Expression Omnibus (GEO) database, correspondingly divided into training testing cohorts then merged. Using limma package, 140 differentially expressed genes (DEGs) screened out between 81 DN samples 41 normal ones cohort. With help...
Abstract Background In recent years, the prevalence and mortality rates of diabetes have been rising continuously, posing a significant threat to public health placing heavy burden on population. This study was conducted describe analyze in China from 1990 2021 its attributable risk factors. Methods Utilizing data Global Burden Disease Study 2021, we analyzed incidence, prevalence, disability‐adjusted life years (DALYs) type 1 (T1DM) 2 (T2DM) 2021. We extracted sex‐ age‐specific diabetes,...
Checkpoint kinases CHK1 and CHK2 are activated in response to DNA damage that results cell cycle arrest, allowing sufficient time for repair. Agents lead abrogation of such checkpoints have potential increase the efficacy compounds as chemo- radiotherapies. Thiophenecarboxamide ureas (TCUs) were identified inhibitors by high throughput screening. A structure-based approach is described using crystal structures JNK1 complex with 1 2 CHK1-3b complex. The ribose binding pocket was targeted...
Adipose tissue dysfunction underpins the association of obesity with type 2 diabetes. Adipogenesis is required for maintenance adipose function. It involves commitment and subsequent differentiation preadipocytes coordinated by autocrine, paracrine, endocrine factors. We previously reported that fibroblast growth factor-1 (FGF-1) primes primary human Simpson Golabi Behmel syndrome (SGBS) increases adipogenesis through a cascade involving extracellular signal-related kinase 1/2 (ERK1/2)....
For tissue engineering applications scaffolds need to have a porous structure meet the needs of cell proliferation/differentiation, vascularisation and sufficient mechanical strength for specific tissue. Here we report results study 3D printing process composite materials based on oxidized nanocellulose gelatin, that was optimised through measuring rheological properties different batches after crosslinking times, simulation pneumatic extrusion fabrication with Solidworks Flow Simulation,...
Understanding structure-fluorescence correlation is very helpful for the design of fluorescent probes. In this paper, a donor-acceptor-donor (D-A-D) type NIR-II fluorophore with benzobisthiadiazole as acceptor and triphenyl amine donor, its three derivatives bearing respectively amino, tert-butyloxycarbonyl amino phenylazo groups in donor moieties, are synthesized. Their electronic structures optical properties investigated via theoretical experimental studies. It found that all types...
Abstract Background and Aims Follistatin-like protein-1 (FSTL-1) is considered to be an adipokine or myokine that could a potential regulator of metabolism. Our purpose investigate the relationship between circulating FSTL-1 levels insulin resistance (IR) in type 2 diabetes mellitus (T2DM) identify regulatory factors. Methods expression C57BL/6J db/db mice was examined by quantitative reverse transcriptase–polymerase chain reaction (qRT-PCR) Western blots. Serum were measured enzyme-linked...
Patients with type 2 diabetes mellitus (T2DM) have been reported to be more susceptible 2019 novel coronavirus (2019-nCoV) and likely develop severe pneumonia. However, the safety immunological responses of T2DM patients after receiving inactivated vaccines are not quite definite. Therefore, we aimed explore safety, antibody responses, B-cell immunity who were vaccinated disease (COVID-19) vaccines.Eighty-nine 100 healthy controls (HCs) enrolled, all whom had received two doses full-course...
BackgroundUncontrolled asthma in growing children can impair lung growth that may lead to adverse complications later life. Dupilumab, a human monoclonal antibody, blocks the shared receptor for IL-4 and IL-13, key drivers of type 2 inflammation.ObjectiveTo extensively evaluate effect dupilumab on function (6-11 years) with moderate-to-severe enrolled phase 3 LIBERTY ASTHMA VOYAGE (NCT02948959).MethodsChildren were randomized 2:1 add-on 100/200 mg by bodyweight or placebo every weeks, 52...
Abstract Zinc-alpha2-glycoprotein (AZGP1) has been implicated in peripheral metabolism; however, its role regulating energy metabolism the brain, particularly POMC neurons, remains unknown. Here, we show that AZGP1 neurons plays a crucial controlling whole-body metabolism. neuron-specific overexpression of Azgp1 under high-fat diet conditions reduces intake, raises expenditure, elevates tissue leptin and insulin sensitivity, alleviates liver steatosis, promotes adipose browning. Conversely,...
The development of bivalent or multivalent vaccines offers a promising strategy for combating SARS-CoV-2 mutations. In this phase 2 trial, conducted from 1 December 2021, to 25 July 2023, 392 unvaccinated adults aged ≥18 years were randomized receive primary series two doses and booster dose SCTV01C, protein vaccine. Geometric mean titers (GMTs) neutralizing antibodies (nAb) against live Alpha, Beta, Delta, Omicron showed 85.4-, 100.0-, 32.1-, 9.8-fold increase baseline on 28 days, 49.4-,...
Background Renal fibrosis is a critical factor in chronic kidney disease progression, with limited diagnostic and therapeutic options. Emerging evidence suggests RNA-binding proteins (RBPs) are pivotal regulating cellular mechanisms underlying fibrosis.