A5064868635- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Photodynamic Therapy Research Studies
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Luminescence Properties of Advanced Materials
- Hepatitis C virus research
- Computational Drug Discovery Methods
- Advanced Nanomaterials in Catalysis
- Polyomavirus and related diseases
- Bacterial Infections and Vaccines
- Innovative Microfluidic and Catalytic Techniques Innovation
- Nanopore and Nanochannel Transport Studies
- Lipid Membrane Structure and Behavior
- Sustainable Industrial Ecology
- Glioma Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Liver Disease and Transplantation
- Global Energy Security and Policy
- Gold and Silver Nanoparticles Synthesis and Applications
Zhejiang Cancer Hospital
2024-2025
Southeast University
2018-2025
Chinese Academy of Sciences
2024-2025
Nantong University
2021
Henan Provincial People's Hospital
2021
Southeast University
2021
Affiliated Hospital of Nantong University
2021
Zhongda Hospital Southeast University
2021
Abstract Background Triple negative breast cancer (TNBC) is an aggressive tumor with extremely high mortality that results from its lack of effective therapeutic targets. As adhesion molecule related to tumorigenesis and metastasis, cluster differentiation-44 (also known as CD44) overexpressed in TNBC. Moreover, CD44 can be effectively targeted by a specific hyaluronic acid analog, namely, chitosan oligosaccharide (CO). In this study, CO-coated liposome was designed, Photochlor (HPPH) the...
Background: Central nervous system tuberculosis (CNS-TB) is the most devastating form of extrapulmonary tuberculosis. Rifampin (RIF) a first-line antimicrobial agent with potent bactericidal action. Nonetheless, blood-brain barrier (BBB) limits therapeutic effects on CNS-TB. Exosomes, however, can facilitate drug movements across BBB. In addition, exosomes show high biocompatibility and drug-loading capacity. They also be modified to increase delivery efficacy. this study, we loaded RIF into...
Hepatocellular carcinoma (HCC) is frequently metastatic once diagnosed and less likely to respond curative surgery, emphasizing the need for development of more sensitive effective diagnostic therapeutic strategies.
Pancreatic cancer remains the leading cause of cancer-related deaths, existence stem cells and lack highly efficient early detection may account for poor survival rate. Gadolinium ion-doped upconversion nanoparticles (UCNPs) provide opportunities combining fluorescent with magnetic resonance imaging, they can improve diagnostic efficacy pancreatic cancer. In addition, as one transmembrane glycoprotein overexpressed on cells, CD326 act a promising target. this study, we developed facile...
Abstract Background Glioblastoma (GBM) is the most invasive primary intracranial tumor, and its effective treatment one of daunting challenges in oncology. The blood–brain barrier (BBB) main obstacle that prevents delivery potentially active therapeutic compounds. In this study, a new type pH-sensitive polymersomes has been designed for glioblastoma therapy to achieve combination radiotherapy chemotherapy U87-MG human xenografts nude mice significantly increased survival time. Results...
Radiation therapy (RT) is commonly used to treat glioblastoma, but its immunomodulatory effect on tumors, through mechanisms such as immunogenic cell death (ICD), relatively weak. Gold nanoparticles (AuNPs) have been suggested potential radio-sensitizers, it unclear if they can enhance radiation-induced ICD. This study aimed investigate the of AuNPs improve effectiveness ICD.G422 cells were treated with a combination and RT induce death. Various assays conducted assess death, surface...
Inducing the immunogenic cell death of tumour cells can mediate occurrence antitumour immune responses and make therapeutic effect more significant. Therefore, development treatments that induce ICD to destroy most effectively is promising. Previously, a new type pH-sensitive polymersome was designed for treatment glioblastoma which represents promising nanoplatform future translational research in therapy. In this study, aim work analyse whether chemoradiotherapy novel cargo-loaded...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of disease (COVID-19), which poses a major threat to humans worldwide. With continuous progress pandemic, growing number people are infected with SARS-CoV-2, including hepatocellular carcinoma (HCC) patients. However, relationship between COVID-19 and HCC has not been fully elucidated. In order provide better treatment for patients it’s urgently needed identify common targets find effective drugs both. our study,...
e16159 Background: Hepatocellular carcinoma (HCC) ranks as the sixth most prevalent cancer worldwide. Notably, over 80% of HCC cases are diagnosed at an intermediate to advanced stage. Transcatheter arterial chemoembolization (TACE) is globally acknowledged standard local treatment for and remains predominant care HCC, While lenvatinib (LEN) or combination bevacizumab (BEV) atezolizumab recognized a first-line systemic therapy HCC. Moreover, TACE+LEN+immune checkpoint inhibitors (ICIs) in...
Hepatocellular carcinoma (HCC) is heterogeneous and refractory with multidimensional features. This study aims to investigate its molecular classifications based on features scores (FSs) support classification-guided precision medicine.
Abstract Background: Pancreatic cancer (PC) is one of the most devastating types cancers worldwide and has a remarkably poor survival rate, emphasizing need for more effective strategies diagnosis therapy PC. Upconversion nanoparticles (UCNPs) have gained privileged place in biomedical field due to their outstanding properties. Besides, epithelial cell adhesion molecule (EpCAM) as key biomarkers pancreatic stem cells, vital target theranostic, diagnostic, and/or therapeutic intervention...