A5034680075- SARS-CoV-2 and COVID-19 Research
- Bone Metabolism and Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Bacterial Infections and Vaccines
- Inflammatory mediators and NSAID effects
- Cancer-related molecular mechanisms research
- Lipid Membrane Structure and Behavior
- COVID-19 Clinical Research Studies
- Computational Drug Discovery Methods
- RNA modifications and cancer
- Extracellular vesicles in disease
- Bone health and treatments
East China Normal University
2024
Zhongda Hospital Southeast University
2022-2023
Background: Central nervous system tuberculosis (CNS-TB) is the most devastating form of extrapulmonary tuberculosis. Rifampin (RIF) a first-line antimicrobial agent with potent bactericidal action. Nonetheless, blood-brain barrier (BBB) limits therapeutic effects on CNS-TB. Exosomes, however, can facilitate drug movements across BBB. In addition, exosomes show high biocompatibility and drug-loading capacity. They also be modified to increase delivery efficacy. this study, we loaded RIF into...
Abstract Hepatocellular carcinoma (HCC) is common worldwide, and novel therapeutic targets biomarkers are needed to improve outcomes. In this study, bioinformatics analyses combined with in vitro vivo assays were used identify the potential targets. Differentially expressed genes (DEG) HCC identified by intersection between The Cancer Genome Atlas International Consortium data. DEGs evaluated a gene set enrichment analysis as well Gene Ontology Kyoto Encyclopedia of Genes Genomes analyses. A...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of disease (COVID-19), which poses a major threat to humans worldwide. With continuous progress pandemic, growing number people are infected with SARS-CoV-2, including hepatocellular carcinoma (HCC) patients. However, relationship between COVID-19 and HCC has not been fully elucidated. In order provide better treatment for patients it’s urgently needed identify common targets find effective drugs both. our study,...
A series of heterocyclic ring-fused derivatives bisnoralcohol (BA) were synthesized and evaluated for their inhibitory effects on RANKL-induced osteoclastogenesis. Most these possessed potent antiosteoporosis activities in a dose-dependent manner. Among compounds, 31 (SH442, IC50 = 0.052 μM) exhibited the highest potency, displaying 100% inhibition at 1.0 μM 82.8% an even lower concentration 0.1 μM, which was much more than lead compound BA (IC50 2.325 μM). Cytotoxicity tests suggested that...