A5103100281- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Organ Transplantation Techniques and Outcomes
- RNA modifications and cancer
- Natural Compounds in Disease Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Psoriasis: Treatment and Pathogenesis
- Cytokine Signaling Pathways and Interactions
- Whipple's Disease and Interleukins
- Galectins and Cancer Biology
- Chemokine receptors and signaling
- Liver physiology and pathology
- Pancreatic and Hepatic Oncology Research
- Cancer Mechanisms and Therapy
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Peripheral Neuropathies and Disorders
- MRI in cancer diagnosis
- Liver Diseases and Immunity
- Autophagy in Disease and Therapy
- Cancer Genomics and Diagnostics
Nanjing Medical University
2015-2025
Jiangsu Province Hospital
2010-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Beijing Automotive Group (China)
2012
Objective This study aimed to assess the efficacy and safety of camrelizumab plus apatinib in patients with resectable hepatocellular carcinoma (HCC) as neoadjuvant therapy. Methods Initially, 20 HCC were screened 18 enrolled this open-label, single-arm, phase II clinical trial. Patients received three cycles therapy including doses concurrent for 21 days followed by surgery. Four 8 weeks after surgery, eight adjuvant combination apatinib. Major pathological reactions (MPR), complete (pCR),...
Matrix Gla protein (MGP) was originally reported as a physiological suppressor of ectopia calcification and has also been to be associated with cancer. However, the relation between biological functions MGP immune response in colorectal cancer (CRC) remains unclear. Here, we investigated regulatory role microenvironment CRC. expression CRC samples assessed by single-cell RNA sequencing Gene Expression Omnibus (GEO) database, confirmed quantitative real-time Polymerase Chain Reaction...
Abstract Background Circular RNA (circRNA), a new class of non-coding RNA, has obvious correlations with the occurrence and development many diseases, including tumors. This study aimed to investigate potential roles circPAK1 in hepatocellular carcinoma (HCC). Methods High-throughput sequencing was performed on 3 pairs HCC matched normal tissues determine upregulated circRNAs. The expression level detected by qRT-PCR paired liver tissue samples. effects proliferation, invasion, metastasis...
Abstract Background Emerging evidence indicates the pivotal involvement of circular RNAs (circRNAs) in cancer initiation and progression. Understanding functions underlying mechanisms circRNAs tumor development holds promise for uncovering novel diagnostic indicators therapeutic targets. In this study, our focus was to elucidate function regulatory mechanism hsa-circ-0003764 hepatocellular carcinoma (HCC). Methods A newly discovered (circPTPN12) identified from circbase database. QRT-PCR...
Interleukin-26 (IL-26) is one of the cytokines secreted by Th17 cells whose role in human tumors remains unknown. Here, we investigated expression and potential IL-26 gastric cancer (GC). The related molecules such as IL-20R1, STAT1 STAT3 was examined real-time PCR immunohistochemisty. effects on cell proliferation cisplatin-induced apoptosis were analyzed BrdU cooperation assay PI-Annexin V co-staining, respectively. Lentiviral mediated siRNA used to explore its mechanism action, signaling...
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. Recurrence and metastasis after curative resection remain critical obstacles in HCC treatment. CD146 predicted poor prognosis a variety cancers including melanoma, breast tumors, prostate cancer, gastric cancer. However, role has not yet been systematically explored. To investigate HCC, we evaluated its expression tissues cell lines using real-time PCR western blotting (WB). Second, established...
All-trans retinoic acid (atRA) is an active metabolite of vitamin A with antioxidant effects. There have been few reports on the effects atRA liver ischemia/reperfusion (I/R) injury. Here we used a rat ischemia/ reperfusion model to analyze protective effect atRA. Rats were administered different does (5—15 mg/kg/d) intraperitoneally (i.p.) for 14 d before I/R. Partial (70%) hepatic ischemia was induced by clamping artery, portal vein, and bile duct left median lobes using vascular clamp 60...
Abstract Thymic-derived regulatory T cell (tTreg) clinical trials show therapeutic promise in the prevention of acute graft-versus-host disease (GVHD) allogeneic hematopoietic stem transplantation patients. However, strategies are needed to improve tTreg proliferative ability and survival as a means therapy reduce requirement for producing large numbers Treg cells adoptive transfer. Autophagy is self-degradative process cytosolic components, which involved death, differentiation, lymphocyte...
Abstract Mesenchymal stem cells (MSCs) possess the ability to migrate toward tumor sites and are regarded as promising gene delivery vehicles for cancer therapeutics. However, factors that mediate this tropism have yet be completely elucidated. In study, through cytokine array analysis, chemokine CCL15 was found most abundant protein differentially expressed in hepatocellular carcinoma (HCC) cell lines compared with a normal liver line. Serum levels HCC patients determined by enzyme linked...
Mounting evidence has demonstrated that circular RNAs have an important function in tumorigenesis and cancer evolvement. CircCRIM1 been shown to be a poor prognostic element multiple human malignancies. However, the clinical significance mechanism of circCRIM1 hepatocellular carcinoma (HCC) is still unclear. The present study confirmed expression level using quantitative real-time PCR. In addition, siRNA overexpression vectors were used for transfection into LM3 or Huh7 cells down-...
e16279 Background: The high recurrence rate following resection presents a significant challenge to the survival of patients with resectable hepatocellular carcinoma (HCC). Therefore, it is imperative develop novel and effective therapeutic interventions reduce improve prognosis HCC. This study aims evaluate efficacy safety camrelizumab combined rivoceranib TACE as perioperative treatment regimen in Methods: In this multicenter, randomized clinical trial, eligible HCC (CNLC stages Ib-IIIa)...
Background/Aims: Critical roles of PTPRO and TLR4 have been implicated in hepatocellular carcinoma. However, little is known about their modifying effects on inflammation-related diseases liver, particularly fulminant hepatitis (FH). We aim to investigate the potential role its interaction with LPS/D-GaIN induced FH. Methods: A mouse FH model was used. RAW264.7 cells were transfected over-expressed lentiviral plasmids for further investigation. Results: The mortality KO mice higher than WT...
This study aimed to investigate the mechanism of galectin (Gal)-1 regulating Treg/Th17 in pathogenesis acute rejection after liver transplantation rat.Mononuclear cells were induced immature dendritic (imDCs), which transfected with or without NF-κB/RelB. Western Blot was performed detect expression CD11c, CD45RB, CD80 and MHC II detected by flow cytometry. Enzyme-linked immunosorbent assay (ELISA) employed cytokines IL-27 TGF-β. Lewis dark agouti (DA) rats generally anaesthetized isoflurane...
Circular RNAs (circRNAs), continuous loops of single-stranded RNA, regulate gene expression during the development various cancers. However, function circRNAs in hepatocellular carcinoma (HCC) is rarely discussed. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to determine mRNA levels circ_0011385, miR-361-3p, and STC2 96 pairs HCC tissues (tumor adjacent normal tissues), cell lines, L02 (human liver line) cells. The relationships between circ_0011385 clinical features...
STAT3 is an oncogene which mainly capable of regulating various biological characters by its transcriptional factor features driving thousands genes. However, upstream noncoding RNA-related regulations still remain unknown. In this study, we focused on the microRNA (miRNA)-associated single nucleotide polymorphisms (SNPs) in 3′ unstranslated region (UTR) to investigate further relationship SNPs with miRNAs among Chinese patients hepatocellular carcinoma (HCC). We found that suffering from...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of disease (COVID-19), which poses a major threat to humans worldwide. With continuous progress pandemic, growing number people are infected with SARS-CoV-2, including hepatocellular carcinoma (HCC) patients. However, relationship between COVID-19 and HCC has not been fully elucidated. In order provide better treatment for patients it’s urgently needed identify common targets find effective drugs both. our study,...
Objectives Hepatocellular carcinoma (HCC) is the most common primary liver cancer and characterized by high aggressiveness extremely poor prognosis. Increasing evidence has suggested that circular RNAs (circRNAs), which are highly stable, play crucial roles in progression of multiple malignancies. However, circRNAs HCC remain elusive. Materials Methods The expression patterns were identified qRT-PCR. A series functional experiments both vivo vitro used to determine role circERBIN...
To resolve multi-point power quality monitor of smart grid and voltage fluctuation industrial mining enterprises,the distributed monitoring system is developed. The includes three parts:monitoring terminal, communication network center. Monitoring terminal can be installed on any node for Monitoring, collect the high speed data grid, show message real-timely. Communication exchange mass between center by using EtherCAT. EtherCAT very excellent at transmission reliability. collects stores all...
4082 Background: Although there is no standard perioperative treatment for resectable HCC characterized with high recurrence rate, the strategy of immunotherapy combined targeted agents promising in neoadjuvant/adjuvant therapy various tumors. Methods: In this perspective, single-arm, exploratory phase II trial (NCT04297202), eligible patients (pts) were systemic treatment-naive intermediate/advanced stage. Preoperative anti-PD-1 antibody camrelizumab (200 mg q2w 3 cycles) and VEGFR-2...