A5060189095- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Pancreatitis Pathology and Treatment
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Global Public Health Policies and Epidemiology
- Viral Infections and Immunology Research
- Immune cells in cancer
- Viral gastroenteritis research and epidemiology
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- COVID-19 Clinical Research Studies
- CAR-T cell therapy research
- Cancer Treatment and Pharmacology
- Phagocytosis and Immune Regulation
- Heme Oxygenase-1 and Carbon Monoxide
- Circular RNAs in diseases
- Pulmonary Hypertension Research and Treatments
- Ferroptosis and cancer prognosis
- Angiogenesis and VEGF in Cancer
- Estrogen and related hormone effects
Nanjing Medical University
2016-2025
Peking University
2004-2025
Jiangsu Province Hospital
2013-2025
Taihe Hospital
2024
Hubei University of Medicine
2024
Institute of Computing Technology
2021-2024
Chinese Academy of Sciences
2017-2024
Tsinghua University
2020-2024
Guangzhou Medical University
2024
Gansu Provincial Hospital
2024
Constitutively active estrogen receptor α (ER/ESR1) mutations have been identified in approximately one-third of ER+ metastatic breast cancers. Although these are known as mediators endocrine resistance, their potential role promoting disease has not yet mechanistically addressed. In this study, we show the presence ESR1 exclusively distant but local recurrences five independent cancer cohorts. concordance with transcriptomic profiling ESR1-mutant tumors, genome-edited Y537S and D538G-mutant...
Abstract Estrogen receptor alpha (ER/ ESR1 ) is frequently mutated in endocrine resistant ER-positive (ER+) breast cancer and linked to ligand-independent growth metastasis. Despite the distinct clinical features of mutations, their role intrinsic subtype switching remains largely unknown. Here we find that mutant cells samples show a significant enrichment basal markers, six cytokeratins (BCKs) are most enriched genes. Induction BCKs independent ER binding instead associated with chromatin...
Background: The APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) family-mediated mutagenesis is widespread in human cancers. However, our knowledge of the biological feature and clinical relevance APOBECs cancers remains limited. Methods: In this study, with a series bioinformatic statistical approaches, we performed comprehensive analysis multiple levels data, including whole-exome sequencing (WES) targeted next-generation (NGS), transcriptome (bulk RNA-seq...
The vaginal microbiota plays a crucial role in female reproductive health and is considered biomarker for predicting disease outcomes personalized testing. However, its relationship with human papillomavirus (HPV) infection cervical cancer not yet clear. Therefore, this article provides review of the association between microbiota, HPV infection, cancer. We discuss composition dysbiosis, as well potential mechanisms development In addition, we assess feasibility treatment strategies such...
Pancreatic ductal adenocarcinoma (PDAC) is one of the malignant lethal tumors. It has been reported that transcriptional regulator Yin Yang-1 (YY1) suppressed invasion and metastasis PDAC. However, function YY1 on proliferation migration pancreatic cancer remains to be clarified. In this study, we found overexpression or knockdown can inhibit promote cells. Digital gene expression sequencing indicates cyclin-dependent kinase inhibitor 3 (CDKN3) may candidate target YY1. Then downregulate...
Background The transition of right ventricle (RV) from a compensated to decompensated state contributes survival in pulmonary arterial hypertension (PAH). This study investigates the significance atrial (RA) dysfunction on disease progression PAH. Methods Eighty patients with PAH, including 58 hemodynamically RV function (PAH-C) and 22 (PAH-D), were compared 80 age-matched sex-matched normal controls. RA longitudinal strain rate (SR) parameters corresponding reservoir (total ε s SR ),...
MiRNAs have been reported to induce certain drug resistance in multiple solid tumors via various mechanisms. Our study aimed investigate whether miRNA-1269b was involved the chemoresistance and progression of non-small cell lung cancer (NSCLC).MTT colony formation assay were conducted determine proliferation apoptosis analyzed by flow cytometry with annexin V/PI. Luciferase reporter performed validate miRNA-targeting sequences. The function miR-1269b cisplatin-resistant evaluated vivo a...
The metastasis of breast cancer (BC) is a complex multi-step pathological process, strictly dependent on the intrinsic characteristics BC cells and promoted by predisposing microenvironment. Although immunotherapy has made important progress in BC, heterogeneity PD-L1 tumor associated macrophages (TAMs) underlying mechanisms development are still not completely elucidated. Small extracellular vesicles (sEVs) represent essential interaction mediators between TAMs. It worth noting to explore...
The study aimed to investigate the role of circular RNA circASS1 in breast cancer cells.Circular RNAs microarray expression profile were analyzed MCF-7, MDA-MB-231, and qRT-PCR western blotting used quantify its parental gene ASS1. Wound healing, migration invasion assay performed. Luciferase system was detect harbored miRNA.CircASS1 MDA-MB-231 is downregulated comparing overexpression could suppress migration. While silence, it promote MiR-4443 functioning as a tumor promoter be captured by...
Objective: To analyze the trend of health literacy level Chinese residents from 2012 to 2023 and predict 2024 2027. Methods: The study collected data on surveillance 2023. Joinpoint regression model was used calculate average annual percent change (AAPC) trend. interrupted time series analysis with Prais-Winsten transformed generalized least squares estimation employed investigate impact the"Healthy China 2030" policy residents' levels. regression, autoregressive integrated moving grey...
体育素养的发展对个体的长期健康至关重要，其素质可以描述为一个人愿意运用运动的潜力来提升生活质量的动机和能力。高校体育课程是培养体育素养的关键，有必要帮助因疾病无法参与剧烈运动的学生参与体育活动，促进心理健康。本研究以体育素养基本策略为基础，运用PBL教学模式，对在必修体育课上学习疾病的大学生进行为期10周的课程干预。结果显示，干预组在10周后体育素养得分和体育学习兴趣得分显著高于遵循传统课程模式的对照组，虽然有所提高，但差异不具有统计学意义。本研究的课程干预方案不仅为高校体育教育提供了参考，也为促进青少年体育素养发展、建立优质的学校体育课程提供了切实可行的方案。
<title>Abstract</title> <bold>Objective</bold> Pancreatectomy remains associated with a high incidence of complications. In certain cases, patients pancreatic ductal adenocarcinoma (PDAC) face challenges in removing intraperitoneal drainage after surgery, leading to potential delays the administration adjuvant chemotherapy (AC) and potentially impacting survival outcomes. The objective this study was evaluate feasibility benefits AC PDAC who are unable remove over 30...
Insulin resistance (IR) is an important factor for the growth and progression of thyroid nodules, which might be associated with distribution, construction, density nodular vascularization. The objective study was to explore association between IR vascularization nodules. A cross-sectional, population-based conducted in Nanjing, China, from June November 2011. Among 10 050 participants aged 40–79 years, 2886 nodule cases were detected 2532 met eligibility criteria enrollment study. Power...
Abstract Most of the patients with lung cancer are diagnosed at advanced stage, and they often lose opportunity surgical therapy, most whom fail to reach good prognosis after chemotherapy. Recently, a few clinical studies have confirmed role adoptive T-cell transfer in maintenance therapy patients. Here, we provided statistical insights into CIKs from three different levels, cell model (in vitro co-culture system), mice situ cancer), research progression stages). We optimized components...
Evaluation of a licensed inactivated enterovirus type 71 (EV71) vaccine is needed in phase IV study with large population to identify its effectiveness and safety for further application.An open-label, controlled trial involving 155 995 children aged 6-71 months was performed; 40 724 were enrolled the group received 2 doses EV71 at an interval 1 month, remaining used as control group. The EV71-infected cases hand, foot, mouth disease monitored groups during follow-up period 14 since 28th day...
Background/Aims: Chronic inflammation plays an important role in the initiation and progression of gastric cancer (GC). However, relationship activated macrophages with mucous epithelium cells initiating maintaining inflammatory process during carcinogenesis remains unclear. Methods: The tumour associated (TAMs) density was characterized by immunohistochemistry, between analysed using vitro culture system that imitates microenvironment. production pro-inflammatory cytokines detected...
Abstract To gain an insight into the molecular mechanisms of cetuximab resistance in colorectal cancer, we generated a cetuximab‐resistant cell line (H508/ CR ) and performed RNA sequencing to identify differential expression patterns noncoding s (nc s) mRNA between cetuximab‐sensitive resistant cells. A total 278 nc transcripts 1,059 were dysregulated The levels nine selected long (lnc validated using quantitative real‐time PCR . Functional analysis revealed that several groups lnc might be...