A5101803598- Chromatin Remodeling and Cancer
- Protein Degradation and Inhibitors
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Acupuncture Treatment Research Studies
- NF-κB Signaling Pathways
- Plant responses to elevated CO2
- Complementary and Alternative Medicine Studies
- Genomics, phytochemicals, and oxidative stress
- Osteoarthritis Treatment and Mechanisms
- interferon and immune responses
- RNA Research and Splicing
- Spine and Intervertebral Disc Pathology
- Ferroptosis and cancer prognosis
- Anaerobic Digestion and Biogas Production
- Neurofibromatosis and Schwannoma Cases
- Mitochondrial Function and Pathology
- Microfluidic and Bio-sensing Technologies
- Medicinal Plants and Bioactive Compounds
- Structural Analysis and Optimization
- Psychosomatic Disorders and Their Treatments
- Cancer Mechanisms and Therapy
Chinese PLA General Hospital
2025
Changchun University of Chinese Medicine
2021-2024
Shandong University
2023-2024
Chinese People's Liberation Army
2024
Shandong Provincial Hospital
2023-2024
Guiyang Medical University
2021
National Natural Science Foundation of China
2021
Guizhou Cancer Hospital
2021
Affiliated Hospital of Guizhou Medical University
2021
Central South University
2013-2020
Cartilage endplate (CEP) degeneration is an important initiating factor leading to intervertebral disc (IVDD). Astaxanthin (Ast) a natural lipid-soluble and red-orange carotenoid which possesses various biological activities, including antioxidant, anti-inflammatory, anti-aging effects in multiple organisms. However, the mechanism of Ast on chondrocytes remain largely unknown. The objective current study was investigate CEP its underlying molecular mechanisms.Tert-butyl hydroperoxide (TBHP)...
Iron overload is a prevalent condition in the elderly, often associated with various degenerative diseases, including intervertebral disc degeneration (IDD). Nevertheless, mechanisms responsible for iron ion accumulation tissues and mechanism that regulate homeostasis remain unclear. Transferrin receptor-1 (TFR1) serves as primary cellular gate, playing pivotal role controlling intracellular levels, however its involvement IDD pathogenesis underlying remains obscure. Firstly, mice model was...
Abstract BRD7 was originally identified as a novel bromodomain gene and potential transcriptional factor. found to be extensively expressed in multiple mouse tissues but highly the testis. Furthermore, located germ cells during stages of spermatogenesis, ranging from pachytene round spermatid stage. Homozygous knockout (BRD7 −/− ) resulted complete male infertility spermatogenesis defects, including deformed acrosomal formation, degenerative elongating spermatids irregular head morphology...
Prevention of epithelial-mesenchymal transition (EMT) provides a novel treatment strategy for tumor metastasis. Our previous studies have shown that diallyl disulfide (DADS) inhibits Ras related C3 botulinum toxin substrate1 (Rac1) expression, being potential agent suppresses migration and invasion colon cancer cells. The study information on the underlying mechanisms.The expression Rac1 EMT markers (vimentin, N-cadherin E-cadherin) in samples was detected. Colon cell lines treated with or...
Long-palate, lung and nasal epithelium clone 1 (LPLUNC1) is a tumour suppressor gene in nasopharyngeal carcinoma (NPC), low expression of LPLUNC1 associated with poor prognosis. Our previous study showed that upregulates Prohibitin (PHB1), pleiotropic protein functions as various cancers. Low PHB1 was also found to be the prognosis NPC patients. However, mechanisms by which potential role are unclear. Here, we stabilised inhibiting ubiquitination, mediated E3 ligase TRIM21. competitively...
The occurrence and progression of intervertebral disc degeneration (IDD) are significantly influenced by the cartilaginous endplate (CEP). Pinocembrin (PIN), a type flavonoid present in propolis botanicals, demonstrates both antioxidant anti-inflammatory characteristics, which could potentially be utilized management. Therefore, it is crucial to investigate how PIN protects against CEP its mechanisms, offering valuable insights for IDD therapy.To protective impact vivo, we created mouse...
This study developed a system (MEC-AD) by integrating single-chamber microbial electrolysis cell (MEC) with anaerobic digestion (AD), aiming to enhance the conversion efficiency of kitchen waste (KW) into biomethane and optimize metabolic pathways. The performance mechanisms MEC-AD were investigated compared those conventional AD, through inoculation original inoculum (UAD) electrically domesticated (EAD), respectively. results show that achieved CH4 yield 223.12 mL/g VS, which was 31.27%...
The proto-oncogene c-Myc encodes a transcription factor that is involved in the regulation of cellular proliferation, differentiation, and apoptosis. Several studies indicate over-expression frequent genetic abnormality nasopharyngeal carcinoma (NPC). Therefore, specifically reducing its level by means established NPC cell lines helps to better understand role pathogenesis NPC. In this study, for first time, we successfully characterized 5-8F line with stably suppressed expression employing...
BRD7 is a tumor suppressor known to inhibit cell proliferation and cycle progression initiate apoptosis in breast cancer. However, the function underlying molecular events of invasion metastasis cancer are not fully understood.BRD7 expression was assessed two stable lines MDA231 MCF7 with overexpression one line interference using qRT-PCR western blotting. CCK8 assay used examine ability cells. Scratch wound healing evaluate migration Both Matrigel three-dimensional assays were performed...
miR-141 is up-regulated and plays crucial roles in nasopharyngeal carcinoma (NPC). However, the molecular mechanism underlying dysregulation of still obscure. Thus, ChIP-PCR was performed to identify c-Myc-binding sites BRD7. qRT-PCR, western blot immunohistochemistry assays were used detect expression its up/down stream molecules. The rescue experiments on c-Myc/miR-141 axis vitro vivo. Our results showed that levels mature miR-141, pre-miR-141 pri-miR-141 downregulated c-Myc knockdown NPC...