A5027350897- Hematopoietic Stem Cell Transplantation
- Photonic and Optical Devices
- Acute Lymphoblastic Leukemia research
- Advanced oxidation water treatment
- Quantum Information and Cryptography
- Pharmaceutical and Antibiotic Environmental Impacts
- Advanced Photocatalysis Techniques
- Advanced Fiber Laser Technologies
- Chromatin Remodeling and Cancer
- RNA modifications and cancer
- Protein Degradation and Inhibitors
- Hemoglobinopathies and Related Disorders
- Nutrition and Health in Aging
- Photorefractive and Nonlinear Optics
- Cancer-related gene regulation
- Plant tissue culture and regeneration
- Inflammatory Bowel Disease
- Polyomavirus and related diseases
- Air Quality and Health Impacts
- Enhanced Recovery After Surgery
- Genomics and Chromatin Dynamics
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- CAR-T cell therapy research
- Cancer Cells and Metastasis
Guangxi Medical University
2019-2025
Beijing Jiaotong University
2023-2025
State Key Joint Laboratory of Environment Simulation and Pollution Control
2023-2025
Peking University
2023-2025
Nanjing University
2019-2024
Kunming University of Science and Technology
2019-2024
Collaborative Innovation Center of Advanced Microstructures
2020-2024
Tongji University
2023-2024
Yanbian University
2024
Genetic Analysis (Norway)
2023
microRNAs (miRNAs) are small non-coding RNAs and have been implicated in the pathology of various diseases, including cancer. Here we report that miRNA profiles changed after knockdown one most important oncogene c-MYC or re-expression a candidate tumor suppressor gene SPLUNC1 nasopharyngeal carcinoma (NPC) cells. Both can down-regulate microRNA-141 (miR-141). miR-141 is up-regulated NPC specimens comparison with normal epithelium. Inhibition could affect cell cycle, apoptosis, growth,...
Sensitive and quantitative assessment of changes in circulating tumor cells (CTCs) can help cancer prognosis the evaluation therapeutics efficacy. However, extremely low occurrence CTCs peripheral blood (approximately one CTC per billion cells) potential molecular biomarkers during process epithelial to mesenchymal transition create technical hurdles enrichment enumeration CTCs. Recently, efforts have been directed toward development antibody-capture assays based on expression common...
Entanglement distribution has been accomplished using a flying drone, and this mobile platform can be generalized for multiple nodes with optical relay among them. Here we develop the first to reshape wave front of photons their low diffraction loss in free-space transmission. Using two drones, where one distributes entangled other serves as node, achieve entanglement Clauser-Horne-Shimony-Holt S parameter 2.59±0.11 at 1 km distance. Key components source, tracking, are developed high...
The quantum satellite is a cornerstone towards practical free-space network and overcomes the photon loss over large distance. However, challenges still exist including real-time all-location coverage multi-node construction, which may be complemented by diversity of modern drones. Here we demonstrate first drone-based entanglement distribution at all-weather conditions 200 meters (test field limited), Clauser-Horne-Shimony-Holt S-parameter exceeds 2.49, within 35 kg take-off weight. With...
A high-flux entangled-photon source is a key resource for quantum optical study and application. Here, it realized in lithium niobate on isolator (LNOI) chip, with 2.79 \ifmmode\times\else\texttimes\fi{} ${10}^{11}$ Hz/mW photon-pair rate 1.53 ${10}^{9}$ Hz/(nm mW) spectral brightness. These data are boosted by over 2 orders of magnitude compared existing technologies. 160-nm-broad bandwidth engineered eight-channel multiplexed energy-time entanglement. Harnessed high-extinction-frequency...
We demonstrate the first compact photonic flywheel with sub-fs time jitter (averaging times up to 10 μs) at quantum-noise limit of a monolithic fiber resonator. Such quantum-limited performance is accessed through novel two-step pumping scheme for dissipative Kerr soliton generation. Controllable interaction between stimulated Brillouin lasing and nonlinearity enhances DKS coherence mitigates thermal instability challenge, achieving remarkable 22-Hz intrinsic comb linewidth an unprecedented...
Abstract Immunomagnetic assay has been developed to detect rare circulating tumor cells (CTCs), which shows clinical significance in cancer diagnosis and prognosis. The generation fine-tuning of the magnetic field play essential roles such toward effective single-cell-based analyses target cells. However, current a limited range gradient, potentially leading aggregation nanoparticles. Consequently, quenching fluorescence signal mechanical damage may occur, lower system sensitivity...
Abstract Bromodomain is a 110 amino acid domain. It evolutionally conserved and found in proteins strongly implicated signal‐dependent transcriptional regulation. BRD7 novel bromodomain gene it downexpressed nasopharyngeal carcinoma (NPC) biopsies cell lines; its function poorly understood. In the present study, tet‐on inducible expression system was used to investigate role of growth cycle progression. We that ectopic NPC cells inhibited progression from G1 S. further performed cDNA array...
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a highly aggressive hematological malignancy with extremely poor outcome. The median overall survival for adult patients 9–13 months. Pediatric are exceedingly rare an unclear clinical course. Currently, no standardized therapy has been established, although acute lymphoblastic leukemia type of treatment appears to be more effective in those who able tolerate chemotherapy. SL-401 targeted directed CD123, protein ubiquitously expressed...
The proto-oncogene c-Myc encodes a transcription factor that is involved in the regulation of cellular proliferation, differentiation, and apoptosis. Several studies indicate over-expression frequent genetic abnormality nasopharyngeal carcinoma (NPC). Therefore, specifically reducing its level by means established NPC cell lines helps to better understand role pathogenesis NPC. In this study, for first time, we successfully characterized 5-8F line with stably suppressed expression employing...
The effects of particulate matter (PMs) from different cities on the nervous system remain unclear. In this study, aqueous solutions 0.45 μm membrane-filtered PM 31 major Chinese were intravenously administered to rats. Neurotoxicity and mechanisms investigated by quantifying rat behavior, analyzing in vivo biomarkers, examining physicochemical properties. PMs had variable impacts responses, as manifested movement speed right ear, particularly at 1 h 4–6 days postexposure. Physiological...
Limited research has focused on the characterization of Crohn's disease (CD) patients with surgical recurrence. This study aimed to evaluate risk factors and postoperative pharmacological prophylaxis patterns for recurrence in CD. Data were obtained from 349 CD over a 5-year follow-up after initial bowel surgery. Risk affecting re-resection analyzed. Multivariate Cox regression analysis was also used identify A nomogram created guide surveillance. total enrolled, median time 68.0 months The...