A5102025495- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Sunflower and Safflower Cultivation
- Virus-based gene therapy research
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Cell death mechanisms and regulation
- Peroxisome Proliferator-Activated Receptors
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Multiple Myeloma Research and Treatments
- SARS-CoV-2 and COVID-19 Research
- Protein Degradation and Inhibitors
- Cancer Mechanisms and Therapy
- Coronary Interventions and Diagnostics
- Redox biology and oxidative stress
- Trauma and Emergency Care Studies
- Macrophage Migration Inhibitory Factor
- Nanowire Synthesis and Applications
- Pressure Ulcer Prevention and Management
People 's Hospital of Jilin Province
2015-2025
Tianjin Hospital
2006-2023
Henan Agricultural University
2020-2022
Southwest Medical University
2022
Hebei Medical University
2022
Second Hospital of Hebei Medical University
2022
Weatherford College
2022
Houston Methodist
2019-2021
Renji Hospital
2021
Shanghai Jiao Tong University
2021
Abstract Tumor-associated macrophages (TAM) are important tumor-promoting cells. However, the mechanisms underlying how tumor and its microenvironment reprogram these cells remain elusive. Here we report that lipids play a crucial role in generating TAMs (TME). Macrophages from both human murine tissues were enriched with due to increased lipid uptake by macrophages. expressed elevated levels of scavenger receptor CD36, accumulated lipids, used fatty acid oxidation (FAO) instead glycolysis...
CAR-T cell therapy is effective for hematologic malignancies. However, considerable numbers of patients relapse after the treatment, partially due to poor expansion and limited persistence cells in vivo. Here, we demonstrate that human polarized expanded under a Th9-culture condition (T9 CAR-T) have an enhanced antitumor activity against established tumors. Compared IL2-polarized (T1) cells, T9 secrete IL9 but little IFN-γ, express central memory phenotype lower levels exhaustion markers,...
Plasmacytoid dendritic cells (pDCs) play a key role in antiviral responses by producing type-1 IFNs. However, recent studies showed that pDCs induce immune suppression and promote tumor growth human ovarian cancer myeloma. The molecular mechanisms underlying pDC acquisition of these properties are unknown. Here we show activated CpG inhibited induced apoptosis myeloma via secreted IFN-α, but direct contact with converted into tumor-promoting suppressing IFN-α production. E-cadherin,...
Chronic obstructive pulmonary disease (COPD) is characterized by lung destruction and inflammation. As a major compound of cigarette smoke, acrolein plays critical role in the induction respiratory diseases. GADD34 known as growth arrest DNA damage-related gene, which can be overexpressed adverse environmental conditions. Here we investigated effects on acrolein-induced injury. The intranasal exposure induced expression GADD34, developing damage with inflammation increase reactive oxygen...
Ulcerative colitis (UC) is a serious chronic inflammatory bowel disease. Oridonin (Ori) has anti‑inflammatory, antibacterial and antitumor activities. The current study aimed to investigate the regulatory role of Ori in UC. BALB/C mice were induced form model UC using dextran sulfate sodium (DSS), after which received high‑(Ori‑H) low‑doses (Ori‑L). Subsequently, length colon was measured hematoxylin and, eosin staining performed detect colonic injury. Western blot analysis expression level...
Abstract Background Transmissible gastroenteritis virus (TGEV) causes enteric infection in piglets, characterized by vomiting, severe diarrhea and dehydration, the mortality suckling piglets is often high up to 100%. Vaccination an effective measure control disease caused TGEV. Methods In this study, cell-cultured TGEV HN-2012 strain was inactivated formaldehyde (FA), β-propiolactone (BPL) or binaryethylenimine (BEI), respectively. Then vaccine prepared with freund's adjuvant, immunization...
Tumor hypoxia induces the expression of growth arrest and DNA damage-inducible protein (GADD34). However, role GADD34 in tumor remains unclear.Gadd34 was knocked-down through lentivirus-mediated short hairpin RNA (shRNA) cells, which were subsequently injected subcutaneously into mice. volumes myeloid-derived suppressor cells (MDSCs) monitored. Isolated MDSCs incubated with supernatant to investigate impact on cytokine secretion MDSCs.We observed that reduction significantly suppressed...
The growth arrest and DNA damage-inducible protein, GADD34, has been proved to be involved in TGF-β signaling pathway correlates with cell death, which are two important mechanisms regulating myofibroblast differentiation apoptosis during tissue repair. But roles of GADD34 myofibroblasts remain unknown. To investigate the function these processes, we subjected WT GADD34(-/-) mice dermal wound healing. Here show that exhibited accelerated closure compared mice. In addition, showed increased...
A transmissible gastroenteritis virus (TGEV) is a porcine enteropathogenic coronavirus, causing acute swine enteric disease especially in suckling piglets. Mesoporous silica nanoparticles (MSNs) are safe vaccine adjuvant, which could enhance immune responses. Our previous research confirmed that nano silicon had immune-enhancing effects with inactivated TGEV vaccine. In this study, we further clarified the mechanism of MSNs on dendritic cells (DCs). results indicated strongly enhanced...
Multiple myeloma is a heterogeneous plasma cell malignancy that remains incurable because of the tendency relapse for most patients. Survival outcomes may vary widely due to patient and disease variables; therefore, it necessary establish more accurate prognostic model improve precision guide clinical therapy. Here, we developed risk score based on gene expression profiles from three independent datasets: GSE6477, GSE13591, GSE24080. In this model, highly survival-associated five genes,...