A5100718871- Ocular Diseases and Behçet’s Syndrome
- Ferroptosis and cancer prognosis
- Spinal Cord Injury Research
- Nerve injury and regeneration
- Immune Response and Inflammation
- Cytomegalovirus and herpesvirus research
- Inflammasome and immune disorders
- Cancer Immunotherapy and Biomarkers
- Electrospun Nanofibers in Biomedical Applications
- Immune cells in cancer
- CAR-T cell therapy research
- interferon and immune responses
- Advanced Nanomaterials in Catalysis
- Bone Tissue Engineering Materials
- Neonatal Respiratory Health Research
- Nanoparticles: synthesis and applications
- RNA modifications and cancer
- Pancreatic function and diabetes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Retinal Diseases and Treatments
- Systemic Lupus Erythematosus Research
- Antimicrobial agents and applications
- Reconstructive Surgery and Microvascular Techniques
Houston Methodist
2020-2025
Huazhong University of Science and Technology
2020-2025
Chongqing Medical University
2020-2024
First Affiliated Hospital of Henan University
2023-2024
China Academy of Chinese Medical Sciences
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2020-2024
Hunan Province Chest Hospital
2024
Second Affiliated Hospital of Jilin University
2017-2023
Jilin University
2015-2022
StemCells (United States)
2021
CAR-T cell therapy is effective for hematologic malignancies. However, considerable numbers of patients relapse after the treatment, partially due to poor expansion and limited persistence cells in vivo. Here, we demonstrate that human polarized expanded under a Th9-culture condition (T9 CAR-T) have an enhanced antitumor activity against established tumors. Compared IL2-polarized (T1) cells, T9 secrete IL9 but little IFN-γ, express central memory phenotype lower levels exhaustion markers,...
CD8+ T cell longevity regulated by metabolic activity plays important roles in cancer immunotherapy. Although vitro–polarized, transferred IL-9–secreting Tc9 (cytotoxic lymphocyte subset 9) cells exert greater persistence and antitumor efficacy than Tc1 cells, the underlying mechanism remains unclear. Here, we show that tumor-infiltrating display significantly lower lipid peroxidation several mouse models, which is strongly correlated with their persistence. Using RNA-sequence functional...
At present, the healing of osteopathy, especially cartilage, has been proven to be difficult. Commonly used treatment methods are autogenous bone grafts and allogeneic grafts, but cannot fully meet clinical requirements due problems related source, price, immunity, other concerns. Thus, combination biomaterials tissue engineering technology become a new direction in research. Among studies on cartilage materials, hydrogels that show biological activity, absorbability after degradability,...
It is well-known that the combination of polymers and nanoparticles (NPs) provides optimised wound dressing accelerates healing. The knowledge about structure properties these materials critical importance in biological processes related to In this study, we prepared a chitosan (CS) film modified with arginine (Arg) gold NPs (AuNPs) investigated its effectiveness as material for Fourier-transform infrared spectroscopy (FTIR) confirmed Arg was successfully grafted on CS. resultant CS-Arg/AuNP...
Chitosan (CS) has been extensively studied as a natural polymer, in the field of wound repair, due to its useful properties, which include lack toxicity and stimulation, excellent biological affinity, degradability, promotion collagen deposition. However, inferior mechanical strength moderate antibacterial properties are drawbacks restricting further clinical application. Many researchers have adopted use nanotechnology, particular metallic nanoparticles (MNPs), order improve specific...
Dendritic cells (DCs) are the major antigen-presenting and play an important role in autoimmune uveitis.Emerging evidence suggests that bile acids (BAs) regulate DCs maturation.However, underlying mechanisms by which BAs function of still need to be clarified.Here, we demonstrate lithocholic acid (LCA) inhibits production pro-inflammatory cytokines expression surface molecules bone marrow-derived dendritic (BMDCs).LCA attenuates severity EAU modulating maturation splenic CD11C + MHCII high...
Abstract Multiple myeloma (MM) is a hematologic malignancy characterized by uncontrolled proliferation of plasma cells in the bone marrow. MM patients with aggressive progression have poor survival, emphasizing urgent need for identifying new therapeutic targets. Here, we show that leukocyte immunoglobulin-like receptor B1 (LILRB1), transmembrane conducting negative immune response, top-ranked gene associated prognosis patients. LILRB1 deficiency inhibits vivo enhancing ferroptosis cells....
Background: China is a country with burden of high rates both TB and multidrug-resistant (MDR-TB). However, published data on pyrazinamide (PZA) resistance are still limited in Hunan province, China. This study investigated the prevalence, transmission, genetic diversity PZA among Mycobacterium tuberculosis isolates province. Methods: Drug susceptibility testing (DST) Bactec MGIT 960 kit pyrazinamidase (PZase) were conducted all 298 MDR clinical isolates. Moreover, 24-locus MIRU-VNTR DNA...
Behcet’s disease (BD) is associated with considerable gut microbiome changes. However, it still remains unknown how the composition of exactly affects development this disease. In study, transplantation stool samples from patients active ocular BD to mice via oral gavage was performed. This resulted in decreases three short chain fatty acids (SCFAs) including butyric acid, propionic acid and valeric feces BD-recipient group. Intestinal barrier integrity receiving damaged as shown by a...
To investigate the effect of succinic acid on development experimental autoimmune uveitis (EAU) and underlying mechanism.Succinic was administrated intraperitoneally to evaluate its effects immune response EAU in mice. Intraocular inflammation evaluated by histopathological scoring. Frequencies Th1/Th17 cells were measured flow cytometry. Concentrations IFN-γ/IL-17A, neutrophil elastase (NE) myeloperoxidase (MPO) determined enzyme-linked immunosorbent test. Infiltration neutrophils...
Targeted immunotherapy with monoclonal antibodies (mAbs) is an effective and safe method for the treatment of malignancies. Development mAbs improved cytotoxicity, targeting new known tumor-associated antigens, therefore continues to be active research area. We reported that Dickkopf-1 (DKK1) a good target human cancers based on its wide expression in different but not normal tissues. As DKK1 secreted protein, binding directly have limited effects cancer cells vivo. The specificity...
Spinal cord injury (SCI) is a common issue in the clinic that causes severe motor and sensory dysfunction below lesion level. FTY720, also known as fingolimod, has recently been reported to exert positive effect on recovery from spinal injury. Through local delivery site, FTY720 effectively integrates with biomaterials, systemic adverse effects are alleviated. However, of proper mass ratio biomaterials neural stem cell (NSC) proliferation differentiation, well functional after SCI, have not...
Limb spasms are phenomena of hyperreflexia that occur after spinal cord injury. Currently, the clinical treatment is less than ideal. Our goal to develop a combination therapy based on individualized medicine reduce spasticity In this study, rats received severe contusive injury at T9 segment cord, followed by gene with adenoassociated virus encoding human neurotrophic factor 3 (AAV-NT3) and 2-week exercise program starting 4 weeks We quantified frequency during swimming test 6 confirmed...
Chitosan (CS) is a natural polymer with applications in wound restorations and coatings for artificial implants. However, the lack of antimicrobial activity restricts its further application. Thus, purpose this study to prepare CS/AuNPs film by adding gold nanoparticles (AuNPs) modify chitosan. Through transmission electron microscopy, we found that presence CS can effectively prevent agglomeration nanoparticles. Furthermore, through CCK experiment, AuNPs at certain concentration improve...