A5100718872- Nerve injury and regeneration
- Graphene and Nanomaterials Applications
- Tryptophan and brain disorders
- Circadian rhythm and melatonin
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Mechanisms and Therapy
- Electrospun Nanofibers in Biomedical Applications
- Neurological Disease Mechanisms and Treatments
- Spinal Cord Injury Research
- Mesenchymal stem cell research
- Macrophage Migration Inhibitory Factor
- Mesoporous Materials and Catalysis
- Neurogenesis and neuroplasticity mechanisms
- Circular RNAs in diseases
- Nerve Injury and Rehabilitation
- Photoreceptor and optogenetics research
- Optical Coatings and Gratings
- Peptidase Inhibition and Analysis
- Supramolecular Self-Assembly in Materials
- Neuroscience and Neuropharmacology Research
- Blind Source Separation Techniques
- EEG and Brain-Computer Interfaces
- Neural Networks and Applications
- Neurobiology and Insect Physiology Research
- Stress Responses and Cortisol
First Affiliated Hospital of Henan University
2023-2024
Huazhong University of Science and Technology
2022-2024
Second Affiliated Hospital of Jilin University
2014-2022
Houston Methodist
2019-2020
Universidad Nacional Autónoma de México
2015
Spinal cord injury (SCI) can lead to permanent and severe functional impairment below the lesion level is still one of most challenging clinical problems. The treatment SCI has progressed with development tissue engineering techniques. Insulin-like growth factor 1 (IGF-1) brain-derived neurotrophic (BDNF) are factors closely related nerve regeneration. In this study, IGF-1 BDNF were successfully immobilized on biodegradable graphene oxide (GO)-incorporated PLGA (PLGA/GO) electrospun...
Escape is an evolutionarily conserved and essential avoidance response. Considered to be innate, most studies on escape responses focused hard-wired circuits. We report here that a neuropeptide NLP-18 its cholecystokinin receptor CKR-1 enable the circuit execute full omega (Ω) turn. demonstrate in vivo mainly secreted by gustatory sensory neuron (ASI) activate head motor (SMD) turn-initiating interneuron (AIB). Removal of or specific knockdown SMD AIB neurons leads shallower turns, hence...
Osteosarcoma (OS) is the most common primary malignant bone tumor with high morbidity in young adults and adolescents. Increasing evidence has demonstrated that aberrant microRNA (miRNA) expression involved OS occurrence development. miR-150 been recently widely studied many cancers, but not including OS. This study aimed to investigate biological role of Here, we found was consistently downregulated tissues cell lines compared matched adjacent normal human osteoblast cells (NHOst), its...
Electroconductive biomaterials combined with bioelectrical stimulation as a treatment for nerve injury has attracted extensive attention in recent years. This study investigated the effect of [email protected] nanomembrane electrical (ES) on promoting functional recovery spinal cord (SCI). In this study, an was prepared and its characterization biological properties were determined by means scanning electron microscope (SEM), atomic force (AFM) X-ray diffraction (XRD). The effects...
The degradable polymer biomaterials have great potential in the field of nerve regeneration, which gradually been applied to spinal cord injury repair. In this study, a polylactic acid-glycolic acid copolymer (PLGA) porous scaffold was prepared by process phase inversion, then surface modified polydopamine (PDA) as substrate, followed adsorption growth factor (NGF) obtain PDA-PLGA/NGF scaffold. characterization and hydrophilicity scaffolds were evaluated electron microscopy, EDX contact...
Abstract Objective The objective of this article is to explore the effect formononetin (FMN) on depressive-like behaviors and neuroinflammation in lipopolysaccharide (LPS)-induced mice. Methods After acclimatization, male Institute Cancer Research mice were randomly divided into normal group, LPS paroxetine group (20 mg/kg), FMN low-dose mg/kg, FMN20), high-dose (40 FMN40), with eight each group. observed by sucrose preference test, tail suspension test (TST), open field test. protein mRNA...
Microtubule-associated protein 1B plays an important role in axon guidance and neuronal migration. In the present study, we sought to discover mechanisms underlying microtubule-associated mediation of We exposed bone marrow mesenchymal stem cells okadaic acid or N-acetyl-D-erythro-sphingosine (an inhibitor stimulator, respectively, phosphatase 2A) for 24 hours. The expression phosphorylated form type I was greater after exposure lower N-acetyl-D-erythro-sphingosine. then injected through ear...
<title>Abstract</title> Learning and memory are essential for animals’ well-being surviving. The underlying mechanisms a major task of neuroscience studies. In this study, we identified circuit consisting ASER, RIC, RIS, AIY, required short-term salt chemotaxis learning (SCL) in <italic>C. elegans</italic>. ASER NaCl sensation possesses ON- OFF-responses is remodeled by conditioning. RIC integrates sensory information stimulation food deprivation generates suppression its calcium response...
This paper aims to develop a desirable EEG-based classification algorithm. For this purpose, the discrete wavelet transform was applied denoise EEG signals. Then, brain’s left and right hand movement features were extracted from denoised signals by independent component analysis (ICA). Finally, support vector machine (SVM) classifier adopted recognize classify of actions. The experimental results show that our method achieves recognition accuracy 89.5% 90.6% respectively. research findings...
Objective To investigate the effect of polylactic-co-glycolic acid (PLGA)/graphene oxide (GO) nanofibers combined with brain derived neurotrophic factor (BDNF) on neural stem cells (NSCs) proliferation and differentiation as well spinal cord injury repair. Methods PLGA/GO were manufactured absorbed BDNF, microstructure PLGA/GO was observed by scanning electron microscope. The loading efficiency release curve BDNF measured ELISA. NSCs implanted surface PLGA/GO/BDNF nanofibers....
Porous silica nanoparticles are considering good systems for drug cargo and liquid separation. In this work we studied the release of rhodamine 6G (Rh6G) from solid porous nanoparticles. Solid SiO<sub>2</sub> spheres were prepared by sol-gel method. Nanoporous channels produced using a surfactant that was removed chemical procedure. Rh6G incorporated into impregnation. The hexagonal structure pores detected XRD confirmed HRTEM micrographs. released particles stirring them in water at...