A5003223158- Wastewater Treatment and Nitrogen Removal
- Microbial Community Ecology and Physiology
- Multiple Myeloma Research and Treatments
- Radio Frequency Integrated Circuit Design
- Microbial Fuel Cells and Bioremediation
- Immune Cell Function and Interaction
- Ammonia Synthesis and Nitrogen Reduction
- Chemokine receptors and signaling
- Retinal and Macular Surgery
- Aerospace Engineering and Energy Systems
- Advanced Power Amplifier Design
- Advancements in PLL and VCO Technologies
- Spacecraft Dynamics and Control
- Glaucoma and retinal disorders
- Guidance and Control Systems
- interferon and immune responses
- Radioactive element chemistry and processing
- Analog and Mixed-Signal Circuit Design
- CAR-T cell therapy research
- Protein Degradation and Inhibitors
- Water Treatment and Disinfection
- Adipose Tissue and Metabolism
- T-cell and B-cell Immunology
- Diet and metabolism studies
- Legume Nitrogen Fixing Symbiosis
Shanghai Jiao Tong University
2018-2025
Yunnan Normal University
2025
Guizhou University
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Northwestern Polytechnical University
2021-2023
Soochow University
2022-2023
Renji Hospital
2021-2023
Tongren Hospital
2019-2022
China Academy of Chinese Medical Sciences
2021
Shanghai University of Electric Power
2021
Recent studies implicate a strong association between elevated plasma branched-chain amino acids (BCAAs) and insulin resistance (IR). However, causal relationship whether interrupted BCAA homeostasis can serve as therapeutic target for diabetes remain to be established experimentally. In this study, unbiased integrative pathway analyses identified unique genetic link obesity-associated IR catabolic gene expression at the level in human mouse populations. genetically obese (
Background Branched‐chain amino acid (BCAA) catabolic defect is an emerging metabolic hallmark in failing hearts human and animal models. The therapeutic impact of targeting BCAA flux under pathological conditions remains understudied. Methods Results BT2 (3,6‐dichlorobenzo[b]thiophene‐2‐carboxylic acid), a small‐molecule inhibitor branched‐chain ketoacid dehydrogenase kinase, was used to enhance catabolism. After 2 weeks transaortic constriction, mice with significant cardiac dysfunctions...
Recent studies show branched-chain amino acid (BCAA) catabolic pathway is defective in obese animals and humans, contributing to the pathogenesis of insulin resistance diabetes. However, context obesity, various processes including dysfunctional lipid metabolism can affect sensitivity glycemic regulation. It remains unclear how BCAA defect may exert direct impacts on glucose without disturbance obesity. The current study characterized lean mice which genetic deletion PP2Cm leads moderate...
Biological nitrogen removal is primarily conducted by bacteria and fungi rather than actinomycetes. However, accumulations of nitrite hydroxylamine could significantly impair the biological process. A strain Streptomyces mediolani, termed EM-B2, was isolated from a cow dung fermentation biogas digester. The removed more 99% ammonium 78% total in presence glucose under environmental conditions 30 °C, carbon/nitrogen ratio 15, 7.4 mg/L dissolved oxygen pH range 7.5–9.0. Maximal rates were 2.29...
The co-existence of hydroxylamine (NH 2 OH) and nitrite (NO – -N) can aggravate the difficulty wastewater treatment. roles in accelerating elimination multiple nitrogen sources by a novel isolated strain Acinetobacter johnsonii EN-J1 were investigated this study. results demonstrated that could eliminate 100.00% NH OH (22.73 mg/L) 90.09% NO -N (55.32 mg/L), with maximum consumption rates 1.22 6.75 mg/L/h, respectively. Prominently, toxic substances both facilitate removal rates. Compared...
Targeting exportin1 (XPO1) with Selinexor (SEL) is a promising therapeutic strategy for patients multiple myeloma (MM). However, intrinsic and acquired drug resistance constitute great challenges. SEL has been reported to promote the degradation of XPO1 protein in tumor cells. Nevertheless, myeloma, precise mechanisms underlying SEL-induced its impact on responsiveness remain largely undefined. We assessed mRNA levels using western blotting RT-qPCR. Cycloheximide (CHX) chase assays blockade...
We theoretically investigate the comprehensive modulation effect of interlayer twisting and external electric field to two-photon absorption (TPA) in twisted graphene/hexagonal boron nitride (tG/hBN) heterojunction with small twist angles (2° < θ 10°) starting from an effective continuum model. It is found that TPA tG/hBN extended visible light band infrared bilayer graphene (tBLG) due increase energy gap caused by potential atomic layer. And coefficient enhanced several times via field,...
Multiple myeloma (MM) is a hematological malignancy characterized by clonal proliferation of malignant plasma cells. Despite extensive research, molecular mechanisms in MM that drive drug sensitivity and clinic outcome remain elusive. Single-cell RNA sequencing was applied to study tumor heterogeneity dynamics 10 individuals before after 2 cycles bortezomib-cyclophosphamide-dexamethasone (VCD) treatment, with 3 healthy volunteers as controls. We identified unfolded protein response...
Multiple myeloma (MM) is an incurable plasma cell malignancy with the hallmark of immunodeficiency, including dysfunction T cells, NK and APCs. Dysfunctional APCs have been reported to play a key role in promoting MM progression. However, molecular mechanisms remain elusive. Here, single-cell transcriptome analysis dendritic cells (DC) monocytes from 10 patients three healthy volunteers was performed. Both DCs were divided into five distinct clusters, respectively. Among them,...
The chemotherapeutic effect of doxorubicin (Dox) is limited by cumulative dose-dependent cardiotoxicity in cancer survivors. Dexrazoxane (DRZ) approved to prevent Dox-induced cardiotoxicity. Humanin and its synthetic analog HNG have a cytoprotective on the heart. To investigate cardioprotective efficacy alone or combination with DRZ against cardiotoxicity, 80 adult male mice were randomly divided into 8 groups receive following treatments via intraperitoneal injection: saline dailym (5...
Decreased cytotoxicity of natural killer (NK) cells has been shown in multiple myeloma (MM). However, the underlying molecular mechanisms remain unclear. Here, by using single-cell RNA sequencing analysis and vitro experiments, we aim to uncover validate molecularly distinctive insights into identifying regulators for NK cell exhaustion provide potential targets novel immune therapies MM.Single-cell was conducted bone marrow peripheral blood samples from 10 newly diagnosed MM patients three...
Background C-reactive protein (CRP) is a prototypical acute phase in humans with the function of regulating immune cells. Serum CRP levels are elevated multiple myeloma (MM), associated MM cell proliferation and bone destruction. However, its direct effects on T lymphocytes have not been elucidated. Methods Public data sets were used to explore correlation infiltration cytotoxicity score CD8 + cells MM. In vitro, repeated freeze-thaw lines taken as tumor antigens load dendritic (DCs) derived...
The mechanisms underlying the functional impairment and metabolic reprogramming of T lymphocytes in multiple myeloma (MM) have not been fully elucidated. In this study, single-cell RNA sequencing was used to compare gene expression profiles cells bone marrow peripheral blood 10 newly diagnosed MM patients versus 3 healthy donors. Unbiased bioinformatics analysis revealed 9 cytotoxic cell clusters. All clusters had higher senescence markers (e.g., KLRG1 CTSW) than control; some...
Abstract Although tropical forest soils contributed substantially global soil methane uptake, observations on fluxes in forests are still sparse, especially Southeast Asia, leading to large uncertainty the estimation of uptake. Here, we conducted two-year (from Sep, 2016 2018) measurements a lowland site Hainan island, China. At this site, were substantial sink, and average annual uptake was estimated at 2.00 kg CH 4 -C ha −1 yr . The seasonality showed strong dry season (−1.00 nmol m −2 s )...