A5021502269- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Liver Disease Diagnosis and Treatment
- Advanced Glycation End Products research
- Lipid metabolism and biosynthesis
- Cardiac Ischemia and Reperfusion
- Diet, Metabolism, and Disease
- Cardiovascular Disease and Adiposity
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Metabolism, Diabetes, and Cancer
- Cardiovascular Function and Risk Factors
- S100 Proteins and Annexins
- Autophagy in Disease and Therapy
- Atherosclerosis and Cardiovascular Diseases
- Diabetic Foot Ulcer Assessment and Management
- Redox biology and oxidative stress
- Mitochondrial Function and Pathology
- Heme Oxygenase-1 and Carbon Monoxide
- Heart Failure Treatment and Management
- Cardiovascular Health and Disease Prevention
- Ion Channels and Receptors
- Acute Kidney Injury Research
Air Force Medical University
2014-2025
Kunming Medical University
2025
Xijing Hospital
2012-2024
Xiamen University
2011-2015
175th Hospital of People's Liberation Army
2014
University of Washington
2013
National Natural Science Foundation of China
2011
Thomas Jefferson University
2011
Louisiana State University
2003-2008
The determination of cysteine and homocysteine levels is great current interest for the monitoring desease states. A new colorimetric method simultaneous detection l-cysteine l-homocysteine has been developed. fluorescein derivative reacts with above amino acids, producing their respective thiazolidines resulting in color changes. Interference from other acids proteins minimal.
Cardiac metabolic remodeling is a central event during heart failure (HF) development following myocardial infarction (MI). It well known that glucose and fatty acid dysmetabolism contribute to post-MI cardiac dysfunction remodeling. However, the role of amino metabolism in HF remains elusive. Branched chain acids (BCAAs) are an important group essential function as crucial nutrient signaling mammalian animals. The present study aimed determine BCAA progression. Utilizing coronary artery...
The Western meat-rich diet is both high in protein and fat. Although the hazardous effect of a fat (HFD) upon liver structure function well recognized, whether co-presence intake contributes to, or protects against, HF-induced hepatic injury remains unclear. Increased branched chain amino acids (BCAA, essential compromising 20% total intake) reduces body weight. However, elevated circulating BCAA associated with non-alcoholic fatty disease injury. mechanisms responsible for this quandary...
The branched-chain amino acids (BCAA) accumulated in type 2 diabetes are independent contributors to insulin resistance. activity of α-keto acid dehydrogenase (BCKD) complex, rate-limiting enzyme BCAA catabolism, is reduced diabetic states, which contributes elevated concentrations. However, the mechanisms underlying decreased BCKD remain poorly understood. Here, we demonstrate that mitochondrial phosphatase 2C (PP2Cm), a newly identified increases activity, was significantly downregulated...
Either insufficient or excessive autophagy causes cellular death and contributes to myocardial ischaemia/reperfusion (I/R) injury. However, mechanisms controlling the 'right-level' of in heart remains unidentified. Thioredoxin-interacting protein (TXNIP) is a pro-oxidative molecule knowing contribute I/R whether how TXNIP may further inhibit suppressed promote cardiac has not been previously investigated.Wild type gene-manipulated adult male mice were subjected I/R. was increased myocardium...
Branched chain amino acids (BCAAs) are associated with the progression of obesity-related metabolic disorders, including type 2 diabetes and nonalcoholic fatty liver disease. However, whether BCAAs disrupt homeostasis hepatic glucose lipid metabolism remains unknown. In this study, we observed that supplementation significantly reduced high-fat (HF) diet–induced accumulation while increasing plasma levels promoting muscular renal accumulation. Further studies demonstrated increased...
As the essential amino acids, branched-chain acid (BCAA) from diets is indispensable for health. BCAA supplementation often recommended patients with consumptive diseases or healthy people who exercise regularly. Latest studies and ours reported that elevated level was positively correlated metabolic syndrome, diabetes, thrombosis heart failure. However, adverse effect of in atherosclerosis (AS) its underlying mechanism remain unknown. Here, we found plasma an independent risk factor CHD by...
Recent studies show branched-chain amino acid (BCAA) catabolic pathway is defective in obese animals and humans, contributing to the pathogenesis of insulin resistance diabetes. However, context obesity, various processes including dysfunctional lipid metabolism can affect sensitivity glycemic regulation. It remains unclear how BCAA defect may exert direct impacts on glucose without disturbance obesity. The current study characterized lean mice which genetic deletion PP2Cm leads moderate...
With a 3D model reconstructed from coronary angiography, intracoronary blood flow can be calculated using computational fluid dynamics (CFD) with fractional reserve (FFR) measured pressure as boundary conditions. The aim of this study is to investigate the clinical feasibility method by evaluating its ability identify myocardial ischemia diagnosed SPECT perfusion imaging (MPI). Patients who underwent both SPECT-MPI and angiography FFR within 1 week were enrolled. Based on summed stress score...
The receptor for advanced glycation end products (RAGE) and thioredoxin (Trx) play opposing roles in diabetic myocardial ischemia-reperfusion (MI/R) injury. We recently demonstrated nitrative modification of Trx leads to its inactivation loss cardioprotection. present study is determine the relationship between augmented RAGE expression diminished activity pertaining exacerbated MI/R injury heart. state was induced mice by multiple intraperitoneal low-dose streptozotocin injections....
Biochemical marker has revolutionized the approach to diagnosis of heart failure. However, it remains difficult assess stability patient. As such, novel means stratifying disease severity are needed. C1q/TNF-Related Protein 3 (CTRP3) and 9 (CTRP9) adipokines that contribute energy homeostasis with additional anti-inflammatory anti-ischemic properties. The aim our study is evaluate concentrations CTRP3 CTRP9 in patients HFrEF (heart failure reduced ejection fraction) whether associated...
The advanced glycation end products (AGEs) are associated with increased cardiac endothelial injury. However, no causative link has been established between AGEs and enhanced injury after ischemia/reperfusion. More importantly, the molecular mechanisms by which may increase remain unknown. Adult rat microvascular cells (CMECs) were isolated incubated AGE-modified bovine serum albumin (BSA) or BSA. After AGE-BSA BSA preculture, CMECs subjected to simulated ischemia (SI)/reperfusion (R). SI/R...
Objective: Recent clinical observations have indicated that nonlethal mechanical trauma significantly increases myocardial infarction risk even in the presence of completely normal coronary arteries. We investigated molecular mechanisms responsible for exacerbation ischemic injury after with a special focus on role tumor necrosis factor α and its potential downstream effector adiponectin, novel adipokine anti-inflammatory cardioprotective properties. Design: Laboratory study. Setting:...
Abstract The effects of the monomer ratio, surfactant, and crosslinker contents on particle size phase‐transition behavior copolymer poly( N ‐isopropylacrylamide‐ co ‐methacrylic acid) (PNIPAAm–MAA) were investigated with Fourier transform infrared, differential scanning calorimetry, dynamic laser scattering techniques. In addition to thermoresponsive property ‐isopropylacrylamide), ionized methacrylic acid groups brought pH sensitivity PNIPAAm–MAA particles. polymer varied amounts...
Adipose-derived stem cells (ADSCs) have the ability to migrate injury sites and facilitate tissue repair by promoting angiogenesis. However, therapeutic effect of ADSCs from patients with diabetes is impaired due oxidative stress. Given that a group metabolic disorders mitochondria are major source reactive oxygen species (ROS), it possible mitochondrial ROS plays an important role in induction diabetic ADSC (dADSC) dysfunction. isolated mice were treated mitoTEMPO, scavenger, or TEMPO,...