A5101966445- Dental materials and restorations
- Dental Erosion and Treatment
- Endodontics and Root Canal Treatments
- Oral microbiology and periodontitis research
- Dental Research and COVID-19
- Dental Trauma and Treatments
- Orthodontics and Dentofacial Orthopedics
- Dental Implant Techniques and Outcomes
- Hepatitis B Virus Studies
- Dental Radiography and Imaging
- Hepatitis Viruses Studies and Epidemiology
- Steroid Chemistry and Biochemistry
- Cholesterol and Lipid Metabolism
- Neuroscience and Neuropharmacology Research
- Adipokines, Inflammation, and Metabolic Diseases
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Bone and Dental Protein Studies
- Protein purification and stability
- Autophagy in Disease and Therapy
- Cardiomyopathy and Myosin Studies
- Cutaneous lymphoproliferative disorders research
- Cell Adhesion Molecules Research
- Sleep and Wakefulness Research
Air Force Medical University
2015-2024
Xijing Hospital
2011-2024
Shihezi University
2024
Sichuan University
2017-2024
West China Hospital of Sichuan University
2024
State Key Laboratory of Oral Diseases
2024
Huzhou Central Hospital
2024
Stomatology Hospital
2023
Zhejiang University
2015-2023
University of Maryland, Baltimore
2015-2022
Rationale: Long-term exercise provides reliable cardioprotection via mechanisms still incompletely understood. Although traditionally considered a thermogenic tissue, brown adipose tissue (BAT) communicates with remote organs (eg, the heart) through its endocrine function. BAT expands in response to exercise, but involvement remains undefined. Objective: This study investigated whether small extracellular vesicles (sEVs) secreted by and their contained microRNAs (miRNAs) regulate...
Either insufficient or excessive autophagy causes cellular death and contributes to myocardial ischaemia/reperfusion (I/R) injury. However, mechanisms controlling the 'right-level' of in heart remains unidentified. Thioredoxin-interacting protein (TXNIP) is a pro-oxidative molecule knowing contribute I/R whether how TXNIP may further inhibit suppressed promote cardiac has not been previously investigated.Wild type gene-manipulated adult male mice were subjected I/R. was increased myocardium...
Rationale: Myocardial vulnerability to ischemia/reperfusion (I/R) injury is strictly regulated by energy substrate metabolism. Branched chain amino acids (BCAA), consisting of valine, leucine and isoleucine, are a group essential that highly oxidized in the heart. Elevated levels BCAA have been implicated development cardiovascular diseases; however, role I/R process not fully understood. The present study aims determine how influence myocardial metabolism further clarify pathophysiological...
Abstract Mesenchymal stem cells (MSCs) delivered into the post-ischemic heart milieu have a low survival and retention rate, thus restricting cardioreparative efficacy of MSC-based therapy. Chronic ischemia results in metabolic reprogramming heart, but little is known about how these changes influence implanted MSCs. Here, we found that excessive branched-chain amino acid (BCAA) accumulation, signature seen was disadvantageous to cardioprotection intramyocardially injected Discovery-driven...
Abstract Mesenchymal stromal cell (MSC) implantation is a promising option for liver repair, but their poor retention in the injured milieu critically blunts therapeutic effects. The aim to clarify mechanisms underlying massive MSC loss post‐implantation and establish corresponding improvement strategies. primarily occurs within initial hours after into or under reactive oxygen species (ROS) stress. Surprisingly, ferroptosis identified as culprit rapid depletion. In ferroptosis‐...
Our previous studies showed that biomodification of demineralized dentin collagen with proanthocyanidin (PA) for a clinically practical duration improves the mechanical properties matrix and immediate resin-dentin bond strength. The present study sought to evaluate ability PA reduce collagenase-induced biodegradation dentin/adhesive interfaces in relevant manner. effects collagenolytic gelatinolytic activity on PA-biomodified were analysed by hydroxyproline assay gelatin zymography. Then,...
To determine whether bonds of contemporary etch-and-rinse adhesives made with ethanol-wet bonding are stronger and more durable than those water-wet bonding, to explore the possible reasons for results.Flat surfaces midcoronal dentin were in extracted human third molars. The randomized into 6 groups according techniques (water- vs bonding) dental [Single Bond 2 (SB), Prime NT (PB), Gluma Comfort (GB)]. After etching rinsing, either left water-moist or immersed ethanol. Following adhesive...
Abstract Bile acid metabolites have been increasingly recognized as pleiotropic signaling molecules that regulate cardiovascular functions, but their role in mesenchymal stromal cells (MSC)‐based therapy has never investigated. It is found overexpression of farnesoid X receptor (FXR), a main for bile acids, improves the retention and cardioprotection adipose tissue‐derived MSC (ADSC) administered by intramyocardial injection mice with myocardial infarction (MI), which shows enhanced...
The farnesoid X receptor (FXR) is a member of the metabolic nuclear superfamily that plays critical regulatory role in cardiovascular physiology/pathology. However, systemic FXR activation chronic phase myocardial infarction (MI)-induced cardiac remodelling and dysfunction remains unclear. In this study, we aimed to elucidate long-term on post-MI dysfunction.Mice underwent either MI surgery or sham operation. At 1 week after MI, both mice were gavaged with 25 mg/kg/d synthetic agonist...
To evaluate the performance of polyetheretherketone (PEEK) versus titanium computer-aided designed and manufactured (CAD-CAM) framework for implant-supported fixed complete dentures (ISFCDs) with a follow-up duration up to 5 years.Consecutively edentulous patients who underwent ISFCDs PEEK or at one dental specialist center were included in this retrospective study. Implant/prosthesis survival rates, mechanical/biological complications, bone soft tissue parameters analyzed. Overall was...
This study evaluated epigallocatechin-3-gallate (EGCG) and epigallocatechin-3-O-(3-O-methyl)-gallate (EGCG-3Me) modified etch-and-rinse adhesives (Single Bond 2, SB 2) for their antibacterial effect bonding stability to dentin. EGCG-3Me was isolated purified with column chromatography preparative high performance liquid chromatography. EGCG were incorporated separately into the adhesive 2 at concentrations of 200, 400, 600 µg/mL. The cured on growth Streptococcus mutans (S. mutans)...
Stem cell therapy is a potentially effective and promising treatment for ischemic heart disease. Resistin, type of adipokine, has been found to bind adipose-derived mesenchymal stem cells (ADSCs). However, the effects resistin on cardiac homing by ADSCs ADSC-mediated cardioprotective have not investigated. were obtained from enhanced green fluorescent protein transgenic mice. C57BL/6J mice subjected myocardial ischemia-reperfusion (I/R) or sham operations. Six hours after I/R operation,...