A5044771935- Liver Disease Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Diet, Metabolism, and Disease
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Cardiovascular Function and Risk Factors
- Alcohol Consumption and Health Effects
- Neuroscience and Neuropharmacology Research
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Cardiac Fibrosis and Remodeling
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Pancreatitis Pathology and Treatment
- Mesenchymal stem cell research
- S100 Proteins and Annexins
- Cardiovascular Disease and Adiposity
- Plant tissue culture and regeneration
- Adipokines, Inflammation, and Metabolic Diseases
- Sleep and Wakefulness Research
- Vitamin D Research Studies
- Signaling Pathways in Disease
- Electrospun Nanofibers in Biomedical Applications
- Aldose Reductase and Taurine
- Conducting polymers and applications
Nanjing University of Chinese Medicine
2023-2024
Xijing Hospital
2021-2024
Air Force Medical University
2010-2024
Nanjing Drum Tower Hospital
2023-2024
Nanjing Agricultural University
2024
Wenzhou Medical University
2020-2021
Nanchang University
2017
Abstract Few intravenously administered mesenchymal stromal cells (MSCs) engraft to the injured myocardium, thereby limiting their therapeutic efficacy for treatment of ischemic heart injury. Here, it is found that irisin pretreatment increases cardiac homing adipose tissue‐derived MSCs (ADSCs) by single and multiple intravenous injections mice with MI/R more than fivefold, which subsequently antiapoptotic, proangiogenic, antifibrotic effects in rats underwent MI/R. RNA sequencing, Kyoto...
Abstract Bile acid metabolites have been increasingly recognized as pleiotropic signaling molecules that regulate cardiovascular functions, but their role in mesenchymal stromal cells (MSC)‐based therapy has never investigated. It is found overexpression of farnesoid X receptor (FXR), a main for bile acids, improves the retention and cardioprotection adipose tissue‐derived MSC (ADSC) administered by intramyocardial injection mice with myocardial infarction (MI), which shows enhanced...
Abstract Background and Aims The relationship between moderate alcohol intake health outcomes among individuals with metabolic dysfunction‐associated fatty liver disease (MAFLD) is complex. Our aim was to investigate the association of minimal consumption all‐cause cause‐specific mortality MAFLD different genders. Methods study included 2630 from Third National Health Nutrition Examination Survey. Cox regression analysis performed assess use measures mortality. Restricted cubic spline curves...
Early repolarization syndrome (ERS) may be a near-Mendelian or an oligogenic disease; however, no direct evidence has been provided to support this theory.We described large Chinese family with nocturnal sudden cardiac death induced by ERS in most of the young male adults. One missense mutation (p.Q1916R) was found major subunit L-type calcium channel gene CACNA1C sequencing candidate genes. A concomitant gain-of-function variant sodium SCN5A (p.R1193Q) rescue phenotype female CACNA1C-Q1916R...
This cohort study aims to elucidate the dose-dependent association of alcohol use with progression steatotic liver disease using a noninvasive, low-cost method.
Metabolic syndrome is a disorder of energy use and storage, which characterized by central obesity, dyslipidemia, raised blood pressure sugar levels. Maternal 25-hydroxyvitamin D deficiency known to cause metabolic changes, chronic disease, increased adiposity in adulthood. However, the underlying mechanism induced (MetS) offspring vitamin deficient pregnant mothers remains unclear. We identified that maternal deficiency enhances oxidative stress, leads development MetS mother her offspring....
Aims:The invasive intramyocardial injection of mesenchymal stromal cells (MSCs) allows for limited repeat injections and shows poor therapeutic efficacy against ischemic heart failure.Intravenous is an alternative method because this route repeated, noninvasive, easy delivery.However, the lack targeting MSCs hinders ability these to accumulate in area after intravenous injections.We investigated whether how overexpression colony-stimulating factor 2 receptor beta subunit (CSF2RB) may...
Background: Phagocytic clearance of dying cells by efferocytosis is pivotal for the inflammation resolution and heart repair after myocardial infarction (MI). Macrophages are considered key phagocytes involved in efferocytosis, however, molecular mechanisms underlying macrophage during MI remain vastly unknown. Here, we aimed to identify role mechanosensor Piezo1 MI. Methods: Myeloid cell-specific deficient mice (Piezo1 ΔLyz2 ) their littermate controls fl/fl underwent or sham operation...
The aim of this case-control study was to document maternal, umbilical arterial metabolic levels and correlations in pregnancies with without 25-hydroxyvitamin D [25(OH)D] deficiency, while, also investigating the expression nuclear factor erythroid 2 related (Nrf2) carbonyl reductase 1 (CBR1) placenta.One hundred participants, 50 deficient for 25(OH)D normal, were recruited from among hospitalized single-term pregnant women who had elected cesarean section. Umbilical placental samples...
Diabetes mellitus (DM) is a comorbidity commonly presenting with metabolic-dysfunction-associated fatty liver disease (MAFLD); however, few tests for interaction have been reported. Our target was to evaluate the prognostic implications of DM in patients different forms MAFLD.Using data from Third National Health and Nutrition Examination Survey (NHANES III) United States, we screened 14,797 participants aged 20-74 who received ultrasound examinations 1988-1994. Among them, 4599 met...
Abstract Background & aims: Data on the effects of liver fibrosis and hepatic steatosis outcomes in diabetic patients are limited. Therefore, we investigated predictive value severity for all-cause mortality diabetes patients. Methods: A total 1,903 with from Third National Health Nutrition Examination Survey (NHANES III) dataset were enrolled. Presumed was evaluated Fibrosis-4 index (FIB-4). The risk corresponding hazard ratio (HR) analyzed Kaplan-Meier method multivariable Cox...
The mitochondrial oxidative phosphorylation system is a major source of injury during myocardial ischemia and reperfusion. Mitochondrial ribosomal proteins (MRPs) assemble as specialized ribosomes to synthesize mtDNA-encoded proteins, which are subunits enzyme complexes the system. Some have been reported be reduced after ischemic injury. However, molecular mechanisms responsible for this decrease remain identified. Here, we found that many translation-related showed decreasing expression...