A5016397291- Mesenchymal stem cell research
- Cardiac Fibrosis and Remodeling
- Signaling Pathways in Disease
- Cardiac Ischemia and Reperfusion
- Adipose Tissue and Metabolism
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Disease and Adiposity
- Neurological Disease Mechanisms and Treatments
- Electrospun Nanofibers in Biomedical Applications
- RNA modifications and cancer
- Acute Ischemic Stroke Management
- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular Function and Risk Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Endometrial and Cervical Cancer Treatments
- Circular RNAs in diseases
- Calpain Protease Function and Regulation
- Click Chemistry and Applications
- Breast Lesions and Carcinomas
- Cancer, Lipids, and Metabolism
- Synthesis and biological activity
- Iron Metabolism and Disorders
- Aldose Reductase and Taurine
- Metabolomics and Mass Spectrometry Studies
Air Force Medical University
2011-2025
Xijing Hospital
2011-2025
Third Affiliated Hospital of Zhengzhou University
2021-2024
Northwest University
2023-2024
Thomas Jefferson University
2017-2022
Ningxia Medical University
2017-2021
Shandong University
2020
Rationale: Long-term exercise provides reliable cardioprotection via mechanisms still incompletely understood. Although traditionally considered a thermogenic tissue, brown adipose tissue (BAT) communicates with remote organs (eg, the heart) through its endocrine function. BAT expands in response to exercise, but involvement remains undefined. Objective: This study investigated whether small extracellular vesicles (sEVs) secreted by and their contained microRNAs (miRNAs) regulate...
Background: Cell therapy remains the most promising approach against ischemic heart injury. However, poor survival of engrafted stem cells in environment limits their therapeutic efficacy for cardiac repair after myocardial infarction. CTRP9 (C1q/tumor necrosis factor–related protein-9) is a novel prosurvival cardiokine with significantly downregulated expression Here we tested hypothesis that might be required healthy microenvironment promoting implanted cell and cardioprotection. Methods:...
Either insufficient or excessive autophagy causes cellular death and contributes to myocardial ischaemia/reperfusion (I/R) injury. However, mechanisms controlling the 'right-level' of in heart remains unidentified. Thioredoxin-interacting protein (TXNIP) is a pro-oxidative molecule knowing contribute I/R whether how TXNIP may further inhibit suppressed promote cardiac has not been previously investigated.Wild type gene-manipulated adult male mice were subjected I/R. was increased myocardium...
Mesenchymal stromal cell-based therapy is promising against ischemic heart failure. However, its efficacy limited due to low cell retention and poor paracrine function. A transmembrane protein capable of enhancing cell-cell adhesion, N-cadherin garnered attention in the field stem biology only recently.The current study investigates whether how may regulate mesenchymal cells cardioprotective capability failure.Adult mice-derived adipose tissue-derived (ADSC) were transfected with adenovirus...
Abstract Few intravenously administered mesenchymal stromal cells (MSCs) engraft to the injured myocardium, thereby limiting their therapeutic efficacy for treatment of ischemic heart injury. Here, it is found that irisin pretreatment increases cardiac homing adipose tissue‐derived MSCs (ADSCs) by single and multiple intravenous injections mice with MI/R more than fivefold, which subsequently antiapoptotic, proangiogenic, antifibrotic effects in rats underwent MI/R. RNA sequencing, Kyoto...
BACKGROUND: Myocardial mitochondrial dysfunction underpins the pathogenesis of heart failure (HF), yet therapeutic options to restore myocardial function are scarce. Epigenetic modifications DNA (mtDNA), such as methylation, play a pivotal role in modulating homeostasis. However, their involvement HF remains unclear. METHODS: Experimental models were established through continuous angiotensin II and phenylephrine (AngII/PE) infusion or prolonged ischemia/reperfusion injury. The landscape N 6...
Background Poor engraftment of intramyocardial stem cells limits their therapeutic efficiency against myocardial infarction ( MI )‐induced cardiac injury. Transglutaminase cross‐linked Gelatin (Col‐Tgel) is a tailorable collagen‐based hydrogel that becoming an excellent biomaterial scaffold for cellular delivery in vivo. Here, we tested the hypothesis Col‐Tgel increases retention intramyocardially‐injected cells, and thereby reduces post‐ Methods Results Adipose‐derived mesenchymal ADSC s)...
Abstract Bile acid metabolites have been increasingly recognized as pleiotropic signaling molecules that regulate cardiovascular functions, but their role in mesenchymal stromal cells (MSC)‐based therapy has never investigated. It is found overexpression of farnesoid X receptor (FXR), a main for bile acids, improves the retention and cardioprotection adipose tissue‐derived MSC (ADSC) administered by intramyocardial injection mice with myocardial infarction (MI), which shows enhanced...
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) has become the most prevalent type of heart failure, but effective treatments are lacking. Cardiac lymphatics play a crucial role in maintaining health by draining fluids and immune cells. However, their involvement HFpEF remains largely unexplored. METHODS: We examined cardiac lymphatic alterations mice comorbid obesity hypertension, tissues from patients HFpEF. Using genetically engineered mouse models various cellular...
Stem cell therapy is a potentially effective and promising treatment for ischemic heart disease. Resistin, type of adipokine, has been found to bind adipose-derived mesenchymal stem cells (ADSCs). However, the effects resistin on cardiac homing by ADSCs ADSC-mediated cardioprotective have not investigated. were obtained from enhanced green fluorescent protein transgenic mice. C57BL/6J mice subjected myocardial ischemia-reperfusion (I/R) or sham operations. Six hours after I/R operation,...
Hyperglycemia aggravates brain damage caused by cerebral ischemia/reperfusion (I/R) and increases the permeability of blood‑brain barrier (BBB). However, there are relatively few studies on morphological changes BBB. The present study aimed to investigate effect hyperglycemia BBB following I/R injury. Streptozotocin‑induced hyperglycemic citrate‑buffered saline‑injected normoglycemic rats were subjected 30 min middle artery occlusion. Neurological deficits evaluated. Brain infarct volume was...
It has been reported that hyperhomocysteinemia (HHcy) is associated with neurodegenerative and cardiovascular diseases. However, little known about brain histomorphology, neuronal organelles, hairy enhancer of split ( hes) expression under HHcy. In this study, non-HHcy HHcy induced by high-methionine diet in apolipoprotein E-deficient (Apo E-/-) mice were comparatively investigated. The ultrastructure, autophagosomes, apoptosis, proteins, HES1, HES5 P62, designed to assess the effects on...
Selenium and selenoproteins play important roles in neuroprotection against glutamate-induced cell damage, which mitochondrial dysfunction is considered a major pathogenic feature.Recent studies have revealed that fission could activates initiated death pathway.The objectives of the study are to determine whether glutamate induced mediated through pathway activation autophagy, overexpression selenoprotein H can protect cells from toxicity by preserving morphology suppressing...
Invasive micropapillary carcinoma (IMPC) is a rare subtype of breast cancer that lacks prognostic prediction model. Its treatment and factors remain controversial. Our study aimed to develop nomograms predict overall survival (OS) cancer-specific (CSS) in IMPC patients.A total 2149 patients confirmed have between 2003 2018 were selected from the Surveillance, Epidemiology End Results (SEER) database. They divided into training validation cohorts. Univariate multivariate Cox regression...
Aims:The invasive intramyocardial injection of mesenchymal stromal cells (MSCs) allows for limited repeat injections and shows poor therapeutic efficacy against ischemic heart failure.Intravenous is an alternative method because this route repeated, noninvasive, easy delivery.However, the lack targeting MSCs hinders ability these to accumulate in area after intravenous injections.We investigated whether how overexpression colony-stimulating factor 2 receptor beta subunit (CSF2RB) may...
Abstract Introduction The Polycomb group (PcG) is an important family of transcriptional regulators that controls growth and tumorigenesis. PcG mainly consists two complexes, PRC1 Repressive Complex 2 (PRC2). Polycomb-like (PCL2) known to interact with the PRC2 protein. role PCL2 in development progression glioma unclear. Methods We use Cancer Genome Atlas (TCGA) database detect expression various tumors. 117 cases clinical (WHOI–IV) were collected, localization detected by...
<h3>Objectives</h3> Evidence exists that the increase of TNFα is associated with reperfusion injury in patients myocardial infarction after PCI. Adiponectin (APN) anti-inflammatory and cardioprotective protein suppressed by TNFα, significantly reduced during MI/R. Whether neutralising protects against MI/R through upregulation APN level has not been previously investigated. <h3>Methods Results</h3> Adult male C57 mice were subjected to 30 min MI followed 3h or 24h sham for this study....