Diabetic nephropathy (DN) is a major cause of end-stage renal disease (ESRD). Glycyrrhizic acid (GA) an effective inhibitor reactive oxygen species (ROS) production. We investigated the role GA in progression injury DN. Albumin (Alb)/creatinine (crea) levels were significantly lower, and histopathology was attenuated diabetic db/db mice that treated with (15 mg/kg via intraperitoneal injection) once per day for eight weeks. These changes associated lower α -smooth muscle actin ( -SMA)...

Gastric cancer (GC) is one of the most fatal digestive tumors worldwide. Abnormal activation or accumulation nuclear factor-erythroid 2-related factor 2/heme oxygenase 1 (Nrf2/HO-1) axis a malignant event in numerous solid tumors. However, its involvement angiogenesis GC remains unknown. This study investigated role Nrf2/HO-1 GC.The expression Nrf2, HO-1, and vascular endothelial growth (VEGF) BGC-823 cells under hypoxia was analyzed using immunocytochemistry, immunofluorescence, Western...

Hyperglycemia exacerbates brain damage caused by cerebral ischemia. Neuroinflammation may play a role in mediating such enhanced damage. The objectives of this study were to examine the mRNA and protein levels cell type distribution ICAM-1 after ischemia normo-and diabetic hyperglycemic rats.Compared normoglycemic animals, diabetes aggravated neuronal death, decreased Nissl body staining, increased frontal cortex. was located not only vascular endothelial cells but also cortical neurons.Our...

Long noncoding RNA FOXD2 adjacent opposite strand RNA1 (FOXD2-AS1) plays an oncogenic role in various cancers, including gastric cancer (GC). However, the function of FOXD2-AS1 regulating radiosensitivity GC cells and its underlying molecular mechanisms have not been elucidated. This study aimed to figure out potential cell radiosensitivity. RT-qPCR revealed upregulation exposed radiation. Subcellular fractionation assay was used localize cells. Colony formation, MTT, EdU, flow cytometry...

The aim of this study is to investigate the effect extracellular signal-regulated kinases 1/2 (ERK1/2) inhibitor, PD98059, on high blood pressure and related vascular changes. Blood was recorded, thicknesses renal small artery walls were measured ERK1/2 immunoreactivity erk2 mRNA in smooth muscle cells (VSMCs) endothelial detected by immunohistochemistry situ hybridization normotensive wistar kyoto (WKY) rats, spontaneously hypertensive rats (SHR) PD98059-treated SHR. Compared with...

Epilepsy is a prevalent neurological disorder that was reported to affect about 56 million people in the world. Approximately one-third of epileptic patients suffer from seizures do not receive effective medical treatment. The aim this study determine potential anticonvulsant activities Baldrinal (BAL) with mouse model pilocarpine (PILO)-induced epilepsy. mice were treated different doses BAL or sodium valproate prior PILO injection. Spontaneous and evoked evaluated EEG recordings, their...

BACKGROUND:Diabetes aggravates cerebral ischemia/reperfusion (I/R) injury by increasing inflammatory reactions, but its specific mechanism is currently unclear. MATERIAL AND METHODS:Diabetes was induced in mice with a high-fat diet combined streptozotocin. These were subjected to transient middle artery occlusion (tMCAO) for 60 min, followed reperfusion 24–72 h and post-treatment glycyrrhizic acid (GA). Control diabetic randomly allocated 8 groups of 18 each. Blood glucose, brain infarction,...

To further elucidate the molecular mechanisms involved in hypertensive vascular remodeling, an immunohistochemical technique and Western blot were applied to study phospho-extracellular signal-regulated kinase (ERK1/2) transforming growth factor β1 (TGF-β1) expression endothelial smooth muscle cell (VSMC) of thoracic aorta renal arterioles from SHR different ages. Results both immunohistochemistry assays showed that either phospho-ERK1/2 at endothelium or VSMC small arteries SHR8, SHR16,...

Peri-implant osteolysis (PIO) and the subsequent aseptic loosening are main reasons for artificial joint implant failure. Existing methods treating far from satisfactory, necessitating advanced drug exploration. This study is aimed at investigating effect underlying mechanism of tetrandrine (Tet) on inflammatory osteolysis. We established a Ti particle-induced mouse model administered Tet or an equal volume phosphate-buffered saline (PBS). Two weeks later, specimens were collected....

Aseptic loosening associated with wear particle-induced inflammation is a major cause of joint implant failure.Recent studies have demonstrated the therapeutic effects p38 mitogen-activated protein kinase (MAPK)-based therapies on chronic inflammatory diseases.The purpose this study was to investigate whether SB203580, MAPK inhibitor, inhibits debris-induced osteolysis in mice through downregulation receptor activator nuclear factor kβ (RANK)/RANK ligand (RANKL).We used murine model effect...

Empathy between doctors and patients is crucial in enhancing patient satisfaction with medical consultations. This study, grounded empathy theory, employs natural language processing machine learning algorithms to explore the factors influencing online healthcare services, particularly impact of doctor-patient empathy.

The feeding behaviour of omethoate-resistant and susceptible strains the spider mites (Tetranychus cinnabarinus) on cowpea leaves was studied by electrical penetration graph (EPG). EPG waves mite were divided to two forms, high frequency (7.7-8.7 Hz) low (2.4-3.0 Hz), representing non-feeding respectively. average duration periods not significantly different between resistant mites. However, amplitudes greater in pesticide-resistant than

The carmine spider mite Tetranychus cinnabarinus (Boisduvals) is a serious pest on vegetable and fibre crops often causes considerable loss in yield. Previous reports have shown that the increase activity of glutathion-S-aromatic groups transferases (GSAT) an important mechanism resistance to organophosphorus pesticides. GSAT GSH-S-alkyltransterases GSH-S-transferases body are mainly associated with pesticide resistance. In this paper, regression method was adopted select optimal combination...

Background It is well known that diabetic retinopathy(DR) involves in complex pathogenesis.Worse outcome of brain ischemia with hyperglycemia mediated by mitogen-activated protein kinases (MAPK).However,the effect phosphorylation MAPK signal pathway on DR needs further investigation.Objective This study was to explore the possible role extracellular signal-regulated kinase1/2(ERK1/2)in DR.Methods Sixty SPF SD rats aged 8-weeks were grouped into control group and diabetes group.Diabetic...