A5101914034- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Osteoarthritis Treatment and Mechanisms
- RNA Research and Splicing
- MicroRNA in disease regulation
- Oxidative Organic Chemistry Reactions
- Autophagy in Disease and Therapy
- Antioxidant Activity and Oxidative Stress
- Cytokine Signaling Pathways and Interactions
- Orthopaedic implants and arthroplasty
- Free Radicals and Antioxidants
- Corneal Surgery and Treatments
- Circular RNAs in diseases
- Tissue Engineering and Regenerative Medicine
- Biochemical and biochemical processes
- Bone Metabolism and Diseases
- RNA Interference and Gene Delivery
- Genomics and Phylogenetic Studies
- Cancer-related Molecular Pathways
- Meat and Animal Product Quality
- Extracellular vesicles in disease
- Plant Ecology and Soil Science
- Edible Oils Quality and Analysis
- Whipple's Disease and Interleukins
- Cell Adhesion Molecules Research
Zhejiang University
2012-2025
Affiliated Eye Hospital of Wenzhou Medical College
2022-2025
Wenzhou Medical University
2022-2025
Ningxia Medical University
2013-2025
University of Illinois Urbana-Champaign
2023-2024
Fujian Normal University
2022-2024
Sun Yat-sen University
2017-2024
Nanjing Medical University
2012-2024
Suzhou Municipal Hospital
2014-2024
South China Agricultural University
2024
Semantic segmentation in bird's eye view (BEV) is an important task for autonomous driving. Though this has attracted a large amount of research efforts, it still challenging to flexibly cope with arbitrary (single or multiple) camera sensors equipped on the vehicle. In paper, we present BEVSegFormer, effective transformer-based method BEV semantic from rigs. Specifically, our first encodes image features cameras shared backbone. These are then enhanced by deformable encoder. Moreover,...
Osteoarthritis (OA) is the most common musculoskeletal disease, and it has a complex pathology unknown pathogenesis. Chondrocyte ferroptosis closely associated with development of OA. As drug administered for treatment type 2 diabetes, metformin (Met) known to inhibit ferroptosis. However, its therapeutic effect in OA remains unknown. The present study aimed explore effects Met on cartilage subchondral bone mouse model potential underlying mechanisms.A was induced using destabilization...
Abstract Although over 170 chemical modifications have been identified, their prevalence, mechanism and function remain largely unknown. To enable integrated analysis of diverse RNA modification profiles, we developed RMBase v3.0 (http://bioinformaticsscience.cn/rmbase/), a comprehensive platform consisting eight modules. These modules facilitate the exploration transcriptome-wide landscape, biogenesis, interactome functions modifications. By mining thousands epitranscriptome datasets with...
Abstract Pulmonary fibrosis is a consequence of chronic lung injury and associated with high mortality. Despite the pathogenesis pulmonary remaining as an enigma, immune responses play critical role in deregulation wound healing process after injury, which leads to fibrosis. Accumulating evidence argues rationales for current treatments using immunosuppressive agents such corticosteroids. In this study, we report that bleomycin (BLM), well-known fibrogenic agent functioning TLR2 agonist,...
Abstract Non-coding RNAs (ncRNAs) are emerging as key regulators of various biological processes. Although thousands ncRNAs have been discovered, the transcriptional mechanisms and networks majority not fully investigated. In this study, we updated ChIPBase to version 3.0 (https://rnasysu.com/chipbase3/) provide most comprehensive regulation atlas protein-coding genes (PCGs). has identified ∼151 187 000 regulatory relationships between ∼171 600 ∼3000 by analyzing ∼55 ChIP-seq datasets, which...
Although thousands of pseudogenes have been annotated in the human genome, their transcriptional regulation, expression profiles and functional mechanisms are largely unknown. In this study, we developed dreamBase (http://rna.sysu.edu.cn/dreamBase) to facilitate investigation DNA modification, RNA regulation protein binding potential expressed from multidimensional high-throughput sequencing data. Based on ∼5500 ChIP-seq DNase-seq datasets, identified genome-wide various...
Synovial inflammation and fibrosis are important pathological changes associated with osteoarthritis (OA). Herein, we investigated if nintedanib, a drug specific for pulmonary fibrosis, plays positive role in osteoarthritic synovial fibrosis. We assessed the effect of nintedanib on mouse model OA created by destabilization medial meniscus macrophage M1 polarization stimulating RAW264.7 cells lipopolysaccharide. Histological staining showed that daily gavage administration significantly...
Recent advances in large language models have demonstrated their potential for automated generation of hardware description (HDL) code from high-level prompts.Researchers utilized fine-tuning to enhance the ability these (LLMs) field Chip Design.However, lack Verilog data hinders further improvement quality by LLMs.Additionally, absence a and electronic design automation (EDA) script augmentation framework significantly increases time required prepare training dataset LLM trainers.This paper...
// Xiao-Lan Li 1, 2, * , Jianbiao Zhou Zit-Liang Chan 1 Jing-Yuan Chooi Zhi-Rong Chen 2 Wee-Joo Chng 3, 4 Cancer Science Institute of Singapore, National University Centre for Translational Medicine, Singapore 117599, Republic Department Gastroenterology, Suzhou Municipal Hospital (Eastern), City, Jiangsu Province, 215001, P.R. China 3 Yong Loo Lin School 119074, Hematology-Oncology, Hospital, 119228, These authors have contributed equally to this work Correspondence to: Chng, e-mail:...
Abstract Background There are a variety of internal fixation methods for unstable femoral neck fractures (FNFs), but the best method is still unclear. Femoral system (FNS) dynamic angular stabilization with cross screws, and new implant designed minimally invasive FNFs. In this study, we conducted biomechanical comparison FNS, InterTan nail three cannulated screws treatment Pauwels III FNFs investigate properties FNS. Methods A total 18 left artificial femurs were selected randomly divide...
A cobalt Schiff base catalyst with ionic substituents on the ligand, N,N′-ethylenebis(acetylacetoniminato)-cobalt(II) hexafluorophosphoric pyridinium (Co-[Salen-Py][PF6]2), was synthesized. It displayed an excellent catalytic performance for oxidation of 4-methyl guaiacol to vanillin (conversion = 100%, selectivity 90%). Tentative reaction mechanism research indicated that electron-withdrawing substituent ligand Co(acacen) is responsible high vanillin. Meanwhile, utilizing ethylene glycol...
Retinoblastoma (RB) is the main pediatric intraocular tumor in children. It caused by mutation of suppressor gene RB transcriptional corepressor 1 (RB1). Herein, poly(ethylene glycol) grafted branched polyethyleneimine (hyperbranched-star PEI-g-PEG) was taken as polycationic carrier for preparing nonviral vectors with efficient uptake and hypotoxicity potential retinoblastoma therapy application. The PEI-g-PEG can condense genes effectively cationic, nano-scaled complexes PEG shells were...
Posterior capsule opacification (PCO), the most common complication after cataract surgery, is caused by proliferation, migration and epithelial-mesenchymal transition (EMT) of residual lens epithelial cells in bag. Although surface modification drug loading intraocular (IOLs) have been effective preventing PCO to some extent, safety anti-proliferative application still a major limitation clinical application. In this study, we used non-viral gene delivery systems combination with...