A new kind of bio-inspired terpolymer was synthesized by a conventional free radical terpolymerization dopamine methacrylamide (DMA), 2-(dimethylamino)-ethyl methacrylate (DMAEMA) and 2-methacryloyloxyethyl phosphorylcholine (MPC) with azobisisobutyronitrile (AIBN) as an initiator.

In this work, we report a new approach to prepare high gel performance hydrogels which are used as ionic strength-sensitive drug release systems. Succinic anhydride (SA)-modified xanthan (XG-SA) derivatives were prepared and confirmed by Fourier transform-infrared spectroscopy proton nuclear magnetic resonance spectroscopy. Rheological measurements showed that the storage moduli (G') loss (G'') of XG-SA much higher than native XG suggesting stability hydrogels. could form stable when content...

Posterior capsular opacification (PCO) is the main complication after intraocular lens (IOL) implantation in cataract surgery, which result of epithelial cell (LEC) adhesion, proliferation and migration on IOL at capsule interface. Hydrophilic surface modification, such as heparinization, decreases has been commercialized used clinically. However, clinical long-term observation results show no significant difference between pristine heparinized IOLs.To prevent PCO over long time span, we...

Abstract: Infections after surgery or endophthalmitis are potentially blinding complications caused by bacterial adhesion and subsequent biofilm formation on the intraocular lens. Neither single-function anti-adhesion surface nor contacting killing can exhibit ideal antibacterial function. In this work, a novel (2-(dimethylamino)-ethyl methacrylate- co -2-methacryloyloxyethyl phosphorylcholine) (p (DMAEMA- -MPC)) brush was synthesized "grafting from" method through reversible–addition...

Posterior capsular opacification (PCO) is the most important complication in cataract phacoemulsification and intraocular lens (IOL) implantation surgery, mainly stemming from adhesion, proliferation, transdifferentiation of postsurgically residual epithelial cells (LECs). Previous investigations focused on hydrophilic surface modification IOLs for PCO prevention, such as heparinization. However, long-term clinical show that there no significant difference between pristine heparinized IOLs....

Posterior capsule opacification is one of the complications cataract surgery caused by adhesion and reproduction residual human lens epithelial cells (HLECs) on posterior capsule.

Posterior capsule opacification (PCO) is a significant complication of intraocular lens (IOL) implantation in cataract surgery, which the adhesion and proliferation epithelial cells (LECs) on IOL surface play important roles. In present study, highly swollen hyaluronic acid (HA)/chitosan (CHI) polyelectrolyte multilayer was fabricated via layer by technique. Quartz crystal microbalance with dissipation (QCM-D) results not only show successful construction multilayer, but also indicate its...

Poly(methyl methacrylate) (PMMA) has been widely used for intraocular lenses (IOL) but may lead to posterior capsule opacification (PCO) after implantation due its undesirable hydrophilicity and surface morphology. A novel methacrylisobutyl polyhedral oligomeric silsesquioxane-co-poly methyl methacrylate copolymer (MA POSS–PMMA) was synthesized by a free radical polymerization method improve material properties cytocompatibility. Fourier transform infrared spectroscopy (FT-IR), X-ray...

Poly (dimethylsiloxane) (PDMS) silicones, as a common intraocular lenses material, often lead to the happen of posterior capsule opacification due adhesion and reproduction residual human lens epithelial cells (HLECs) on after surgery. Bacterial infection is potentially catastrophic complication cataract surgery, which occurs within several days implantation lens. A novel poly (methacrylisobutyl polyhedral oligomeric silsesquioxane-co-2-(dimethylamino)-ethyl methacrylate) (p (MA...

Bottom-up fabrication of zwitterionic polymer brushes on intraocular lens for improved biocompatibility Yuemei Han,1,* Xu Xu,1,* Junmei Tang,1,* Chenghui Shen,2 Quankui Lin,1,2 Hao Chen1,2 1School Ophthalmology & Optometry, Eye Hospital, Wenzhou Medical University, 2Wenzhou Institute Biomaterials and Engineering, Chinese Academy Sciences, Wenzhou, People’s Republic China *These authors contributed equally to this work Abstract: Intraocular (IOL) is an efficient implantable device commonly...

Posterior capsular opacification (PCO) is a common complication in cataract surgery. The development of PCO attributed to the combination adhesion, migration, proliferation, and transdifferentiation residual lens epithelial cells (LEC) onto interface intraocular (IOL) material posterior, which initial adhesion beginning step plays important roles. In present study, hydrophilic polyethylene glycol (PEG) was immobilized IOL surface via plasma-aided chemical grafting procedure. attenuated total...

Drug-loaded intraocular lenses (IOLs) have received considerable attention in treating complications that arise after cataract surgery, especially posterior capsular opacification (PCO). However, for a better therapeutic effect, the drug concentration IOLs usually needs to be increased. Herein, we developed multilayer (doxorubicin (DOX)@polyaminoamide (PAMAM) (D@P)/heparin sodium (HEP))5 modified IOLs, which efficiently enhance inhibitory effect on PCO using enhanced autophagy of cationic...

Posterior capsule opacification (PCO), the most common complication after cataract surgery, is caused by proliferation, migration and epithelial-mesenchymal transition (EMT) of residual lens epithelial cells in bag. Although surface modification drug loading intraocular (IOLs) have been effective preventing PCO to some extent, safety anti-proliferative application still a major limitation clinical application. In this study, we used non-viral gene delivery systems combination with...

The ocular biocompatibility of polyhedral oligomeric silsesquioxanes (POSSs) was systematically evaluated for biomedical device applications.

Photodynamic coating was designed on the IOL surface <italic>via</italic> supramolecular self-assembly of α-CD-Ce6 and PPEGMA brushes. Such IOLs can reduce incidence posterior capsular opacification after implantation effectively safely.

Expression of concern for ‘Synthesis MA POSS–PMMA as an intraocular lens material with high light transmittance and good cytocompatibility’ by Bailiang Wang et al. , RSC Adv. 2014, 4 52959–52966, https://doi.org/10.1039/C4RA08060B.

Posterior capsule opacification (PCO) is a significant complication of intraocular lens (IOL) implantation in cataract surgery, which the adhesion and proliferation epithelial cells (LECs) on implanted IOL surface play an important role. The modification to prevent LEC practical way reduce incidence PCO. In this study, multifunctional binary copolymer poly(ethylene glycol) methacrylate (PEGMA) glycidyl (GMA) was synthesized (poly(PEGMA-co-GMA), PPG) chemically grafted onto aminolyzed...