A5102838759- Parallel Computing and Optimization Techniques
- Adipose Tissue and Metabolism
- Ocular Surface and Contact Lens
- Intraocular Surgery and Lenses
- Cloud Computing and Resource Management
- Embedded Systems Design Techniques
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Circadian rhythm and melatonin
- Peroxisome Proliferator-Activated Receptors
- Adipokines, Inflammation, and Metabolic Diseases
- Ultrasound and Hyperthermia Applications
- Ocular Infections and Treatments
- Ultrasound Imaging and Elastography
- Lipid metabolism and biosynthesis
- Mitochondrial Function and Pathology
- Immune cells in cancer
- Fibroblast Growth Factor Research
- Graph Theory and Algorithms
- Cholesterol and Lipid Metabolism
- Stroke Rehabilitation and Recovery
- IL-33, ST2, and ILC Pathways
- Retinal and Macular Surgery
- Photoacoustic and Ultrasonic Imaging
- PI3K/AKT/mTOR signaling in cancer
Guangdong University of Technology
2025
Salk Institute for Biological Studies
2014-2025
Beihang University
2025
Wenzhou Medical University
2018-2024
Guilin University of Technology
2024
Affiliated Eye Hospital of Wenzhou Medical College
2018-2024
Sun Yat-sen University
2023-2024
Nanchang University
2024
Beijing Tian Tan Hospital
2021-2024
Capital Medical University
2021-2024
Significance Stromal fibroblasts of the pancreatic tumor microenvironment (TME) have been shown to play both tumor-supportive and tumor-suppressive roles in enacting a dysregulated wound-healing response. This apparent complexity suggests that an improved understanding molecular basis cell–cell interactions TME is required identify target stroma-derived, growth-permissive mechanisms. Here we show stromal cues induce transcriptional metabolic changes cancer cells implicated anabolic...
Pharmacological activation of peroxisome proliferator-activated receptor δ/β (PPARδ/β) improves glucose handling and insulin sensitivity. The target tissues drug actions remain unclear. We demonstrate here that adenovirus-mediated liver-restricted PPARδ reduces fasting levels in chow- high fat-fed mice. This effect is accompanied by hepatic glycogen lipid deposition as well up-regulation utilization de novo lipogenesis pathways. Promoter analyses indicate regulates metabolic programs through...
Hyperglycemia is a result of impaired insulin action on glucose production and disposal, major target antidiabetic therapies. The study insulin-independent regulatory mechanisms metabolism may identify new strategies to lower blood sugar levels. Here we demonstrate an unexpected metabolic function for IL-13 in the control hepatic production. Th2 cytokine known mediate macrophage alternative activation. Genetic ablation Il-13 mice (Il-13–/–) resulted hyperglycemia, which progressed resistance...
Metabolic pathways and inflammatory processes are under circadian regulation. Rhythmic immune cell recruitment is known to impact infection outcomes, but whether the clock modulates immunometabolism remains unclear. We find that molecular Bmal1 induced by stimulants, including Ifn-γ/lipopolysaccharide (M1) tumor-conditioned medium, maintain mitochondrial metabolism metabolically stressed conditions in mouse macrophages. Upon M1 stimulation, myeloid-specific knockout (M-BKO) renders...
IL-13 hits the gym Interleukin-13 (IL-13) is a cytokine secreted by T cells, innate lymphoid cells (ILC2s), and granulocytes. It acts as central mediator in allergy antihelminth defense with various effects. Knudsen et al. report distinct role for exercise metabolism (see Perspective Correia Ruas). Mice subjected to endurance training showed increases circulating IL-13, which correlated ILC2 expansion muscles. By contrast, exercise-induced muscle fatty acid utilization mitochondrial...
Domain-specific hardware accelerators can provide orders of magnitude speedup and energy efficiency over general purpose processors. However, they require extensive manual effort in design software stack development. Automated ASIC generation (eg. HLS) be insufficient, because the becomes inflexible. An ideal accelerator framework would automatable, enable deep specialization to domain, maintain a uniform programming interface. Our insight is that many prior architectures approximated by...
Mammalian acyl-CoA thioesterases (Acots) catalyze the hydrolysis of fatty acyl-CoAs to form free acids plus CoA, but their metabolic functions remain undefined. Thioesterase superfamily member 1 (Them1; synonyms Acot11, StarD14, and brown fat inducible thioesterase) is a long-chain thioesterase that highly expressed in adipose tissue regulated by both ambient temperature food consumption. Here we show Them1 −/− mice were resistant diet-induced obesity despite greater exhibited increased O 2...
With slowing technology scaling, specialized accelerators are increasingly attractive solutions to continue expected generational scaling of performance. However, in order accelerate more advanced algorithms or those from challenging domains, supporting data-dependence becomes necessary. This manifests as either data-dependent control (eg. join two sparse lists), memory accesses hash-table access). These forms inherently couple compute with memory, and also preclude efficient vectorization...
Posterior capsular opacification (PCO) is the main complication after intraocular lens (IOL) implantation in cataract surgery, which result of epithelial cell (LEC) adhesion, proliferation and migration on IOL at capsule interface. Hydrophilic surface modification, such as heparinization, decreases has been commercialized used clinically. However, clinical long-term observation results show no significant difference between pristine heparinized IOLs.To prevent PCO over long time span, we...
Dense linear algebra kernels are critical for wireless, and the oncoming proliferation of 5G only amplifies their importance. Due to inductive nature many such algorithms, parallelism is difficult exploit: parallel regions have fine-grain producer/consumer interaction with iteratively changing depen-dence distance, reuse rate, memory access patterns. This makes multi-threading impractical due synchronization, vectorization ineffective non-rectangular iteration domain. CPUs, DSPs, GPUs...
Because of the importance graph workloads and limitations CPUs/GPUs, many processing accelerators have been proposed. The basic approach prior is to focus on a single algorithm variant (eg. bulk-synchronous + slicing). While helpful for specialization, this leaves performance potential from flexibility table also complicates understanding relationship between types, workloads, algorithms, specialization.In work, we explore value in accelerators. First, identify taxonomy key variants. Then...
Posterior capsular opacification (PCO) is the most important complication in cataract phacoemulsification and intraocular lens (IOL) implantation surgery, mainly stemming from adhesion, proliferation, transdifferentiation of postsurgically residual epithelial cells (LECs). Previous investigations focused on hydrophilic surface modification IOLs for PCO prevention, such as heparinization. However, long-term clinical show that there no significant difference between pristine heparinized IOLs....
Abstract Perovskite smart windows (PSWs) are widely investigated owing to excellent thermochromic properties, while restricted by poor transition performance and cycle stability. Herein, dimethyl sulfoxide vapor is utilized as an induction reagent for rapid reversible switching at room temperature between the colored bleached phases. To obtain PSWs with different optical properties performance, red CsPbIBr 2 , yellow Rb 0.5 Cs PbIBr brown CsSn 0.1 Pb 0.9 IBr prepared through alloying. The...
Nutritional status is a determining factor for growth during development and homeostatic maintenance in adulthood. In the context of muscle, hormone (GH) coordinates with nutritional status; however, detailed mechanisms remain to be fully elucidated. Here, we show that transcriptional repressor B cell lymphoma 6 (BCL6) maintains muscle mass by sustaining GH action. Muscle-specific genetic deletion BCL6 at either perinatal or adult stages profoundly reduces compromises strength. Conversely,...