A5055730615- Immune cells in cancer
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Circadian rhythm and melatonin
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Genomics, phytochemicals, and oxidative stress
- Peroxisome Proliferator-Activated Receptors
- Retinoids in leukemia and cellular processes
- Adipose Tissue and Metabolism
- Immunodeficiency and Autoimmune Disorders
- Exercise and Physiological Responses
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Estrogen and related hormone effects
Harvard University
2019-2022
Case Western Reserve University
2020
Boston University
2020
United States Food and Drug Administration
2020
Metabolic pathways and inflammatory processes are under circadian regulation. Rhythmic immune cell recruitment is known to impact infection outcomes, but whether the clock modulates immunometabolism remains unclear. We find that molecular Bmal1 induced by stimulants, including Ifn-γ/lipopolysaccharide (M1) tumor-conditioned medium, maintain mitochondrial metabolism metabolically stressed conditions in mouse macrophages. Upon M1 stimulation, myeloid-specific knockout (M-BKO) renders...
IL-13 hits the gym Interleukin-13 (IL-13) is a cytokine secreted by T cells, innate lymphoid cells (ILC2s), and granulocytes. It acts as central mediator in allergy antihelminth defense with various effects. Knudsen et al. report distinct role for exercise metabolism (see Perspective Correia Ruas). Mice subjected to endurance training showed increases circulating IL-13, which correlated ILC2 expansion muscles. By contrast, exercise-induced muscle fatty acid utilization mitochondrial...
Type 2 innate lymphoid cells (ILC2) regulate the proliferation of preadipocytes that give rise to beige adipocytes. Whether and how ILC2 downstream Th2 cytokines control adipogenesis remain unclear. We employed cell systems genetic models examine mechanism through which interleukin-13 (IL-13), an ILC2-derived cytokine, controls adipocyte differentiation. IL-13 priming in drives by upregulating beige-promoting metabolic programs, including mitochondrial oxidative metabolism PPARγ-related...
Human Fc receptor-like 3 (FCRL3) is an orphan receptor expressed by lymphocytes, including regulatory T cells. FCRL3 implicated in several autoimmune diseases; however, its function on cells unknown. We discovered that stimulation of inhibited their suppressive function. Moreover, induced IL-17, IL-26, and IFNγ production promoted expression the Th17-defining transcription factor RORγt without affecting FOXP3 expression. suggest engagement mediates a transition to pro-inflammatory Th17-like...
Mitophagy and mitochondrial integrated stress response (ISR) are 2 primary protective mechanisms to maintain functional mitochondria. Whether these processes coordinately regulated remains unclear. Here we show that fission 1 protein (Fis1), which is required for completion of mitophagy, serves as a signaling hub linking mitophagy ISR. In mouse hepatocytes, high fat diet (HFD) feeding induces unresolved oxidative stress, defective enhanced type I interferon (IFN-I) implicated in promoting...
ABSTRACT Metabolic pathways and inflammatory processes are under circadian regulation. While rhythmic immune cell recruitment is known to impact infection outcomes, whether the clock modulates immunometabolism remains unclear. We find molecular Bmal1 induced by stimulants, including Ifn-γ/lipopolysaccharide (M1) tumor conditioned medium, maintain mitochondrial metabolism these metabolically stressed conditions in mouse macrophages. Upon M1 stimulation, myeloid-specific knockout (M-BKO)...