Christina C. Chang
A5081716835- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Cytomegalovirus and herpesvirus research
- Nail Diseases and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Long-Term Effects of COVID-19
- Single-cell and spatial transcriptomics
- Pneumonia and Respiratory Infections
- HIV Research and Treatment
- Pediatric health and respiratory diseases
- HIV/AIDS Research and Interventions
- Neonatal Respiratory Health Research
- Respiratory viral infections research
- SARS-CoV-2 detection and testing
- Antibiotic Use and Resistance
- Mosquito-borne diseases and control
- Herpesvirus Infections and Treatments
- Respiratory and Cough-Related Research
- Sex work and related issues
- Immune Cell Function and Interaction
- HIV, Drug Use, Sexual Risk
- Infectious Diseases and Tuberculosis
- Respiratory Support and Mechanisms
UNSW Sydney
2020-2025
Monash University
2015-2024
Centre for the AIDS Programme of Research in South Africa
2020-2024
The Alfred Hospital
2007-2024
United States Food and Drug Administration
2024
Insmed (United States)
2021-2024
University of California, Davis
2023
University of California, Los Angeles
2023
Alfred Health
2011-2023
Australian Regenerative Medicine Institute
2013-2023
BackgroundLY-CoV555, a neutralizing monoclonal antibody, has been associated with decrease in viral load and the frequency of hospitalizations or emergency department visits among outpatients coronavirus disease 2019 (Covid-19). Data are needed on effect this antibody patients who hospitalized Covid-19.MethodsIn platform trial therapeutic agents, we randomly assigned had Covid-19 without end-organ failure 1:1 ratio to receive either LY-CoV555 matching placebo. In addition, all received...
<h3>Importance</h3> Emerging evidence suggests that risk of bacterial sexually transmitted infections (STIs) increases among gay and bisexual men following initiation HIV preexposure prophylaxis (PrEP). <h3>Objective</h3> To describe STI incidence behavioral factors a cohort predominantly who use PrEP, to explore changes in PrEP commencement. <h3>Design, Setting, Participants</h3> The Pre-exposure Prophylaxis Expanded (PrEPX) Study, multisite, open-label intervention study, was nested within...
SUMMARY Recent surveillance has revealed the emergence of SARS-CoV-2 Omicron variant (BA.1/B.1.1.529) harboring up to 36 mutations in spike protein, target vaccine-induced neutralizing antibodies. Given its potential escape humoral immunity, we measured neutralization potency sera from 88 mRNA-1273, 111 BNT162b, and 40 Ad26.COV2.S vaccine recipients against wild type, Delta, pseudoviruses. We included individuals that were vaccinated recently (<3 months), distantly (6-12 or boosted,...
Objective: HIV-infected patients with treated cryptococcal meningitis are at risk for further neurological deterioration after commencing combination antiretroviral therapy (cART), mostly because of cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS). Identifying predictors C-IRIS could enable stratification. Design: Prospective, longitudinal cohort study 24 weeks. Setting: Durban, South Africa. Participants: One hundred and thirty first episode Intervention:...
Abstract SARS-CoV-2 antibody testing allows quantitative determination of disease prevalence, which is especially important in high-risk communities. We performed anonymized convenience sampling 200 currently asymptomatic residents Chelsea, the epicenter COVID-19 illness Massachusetts, by BioMedomics combined IgM-IgG point-of-care lateral flow immunoassay. The seroprevalence was 31.5% (17.5% IgM+IgG+, 9.0% IgM+IgG−, and 5.0% IgM−IgG+). Of participants, 50.5% reported no symptoms preceding 4...
In a randomized, placebo-controlled, clinical trial, bamlanivimab, SARS-CoV-2-neutralizing monoclonal antibody, given in combination with remdesivir, did not improve outcomes among hospitalized patients COVID-19 based on an early futility assessment.
RNA viruses continue to remain a threat for potential pandemics due their rapid evolution. Potentiating host antiviral pathways prevent or limit viral infections is promising strategy. Thus, by testing library of innate immune agonists targeting pathogen recognition receptors, we observe that Toll-like receptor 3 (TLR3), stimulator interferon genes (STING), TLR8, and Dectin-1 ligands inhibit arboviruses, Chikungunya virus (CHIKV), West Nile virus, Zika varying degrees. STING (cAIMP, diABZI,...
Epstein-Barr virus (EBV) infection of primary human B cells drives their indefinite proliferation into lymphoblastoid cell lines (LCLs). immortalization depends on expression viral latency genes, as well the regulation host genes. Given important role microRNAs (miRNAs) in regulating fundamental cellular processes, this study, we assayed changes miRNA during by EBV. We observed and validated dynamic several miRNAs from early through immortalization; oncogenic were induced, tumor suppressor...
Background. Human immunodeficiency virus–infected patients with treated cryptococcal meningitis who start combination antiretroviral therapy (cART) are at risk of further neurological deterioration, in part caused by paradoxical cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS). We hypothesized that C-IRIS is associated alterations chemokine receptor expression on T cells and concentrations cerebrospinal fluid (CSF) enhance recruitment T-helper 1 and/or myeloid...
T helper 17 (Th17) cells produce interleukin-17 (IL-17) cytokines and drive inflammatory responses in autoimmune diseases such as multiple sclerosis. The differentiation of Th17 is dependent on the retinoic acid receptor-related orphan nuclear receptor RORγt. Here, we identify REV-ERBα (encoded by Nr1d1 ), a member hormone family, transcriptional repressor that antagonizes RORγt function cells. binds to ROR response elements (RORE) inhibits expression RORγt-dependent genes including Il17a...