A5115590666- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Morphological variations and asymmetry
- Treatment of Major Depression
- Advanced MRI Techniques and Applications
- Electroconvulsive Therapy Studies
- Mental Health Research Topics
- Image Retrieval and Classification Techniques
- Medical Image Segmentation Techniques
- Image Processing and 3D Reconstruction
- Neural dynamics and brain function
- Transcranial Magnetic Stimulation Studies
- Data Visualization and Analytics
- Tryptophan and brain disorders
- Dementia and Cognitive Impairment Research
- Neonatal and fetal brain pathology
- 3D Shape Modeling and Analysis
- Cell Image Analysis Techniques
- HIV Research and Treatment
- Paleontology and Evolutionary Biology
- Evolution and Paleontology Studies
- Time Series Analysis and Forecasting
- HIV-related health complications and treatments
- Birth, Development, and Health
- Image and Signal Denoising Methods
Brain Mapping Foundation
2016-2025
University of California, Los Angeles
2016-2025
Neurobehavioral Systems
2016-2024
University of Cape Town
2024
Red Cross War Memorial Children's Hospital
2024
South African Medical Research Council
2024
Wellcome Centre for Human Neuroimaging
2024
King's College London
2024
Neuroscience Institute
2024
Hi Tech BioSciences India (India)
2023
We propose a novel representation of continuous, closed curves in R <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</sup> that is quite efficient for analyzing their shapes. combine the strengths two important ideas-elastic shape metric and path-straightening methods - analysis present fast algorithm finding geodesies spaces. The elastic allows optimal matching features while provides between curves. Efficiency results from fact becomes simple...
Alterations in gray matter (GM) density/volume and cortical thickness (CT) have been demonstrated small heterogeneous samples of subjects with differing chronic pain syndromes, including irritable bowel syndrome (IBS). Aggregating across 7 structural neuroimaging studies conducted at University California, Los Angeles, CA, USA, between August 2006 April 2011, we examined group differences regional GM volume 201 predominantly premenopausal female (82 IBS, mean age: 32±10 SD, 119 healthy...
Electroconvulsive therapy (ECT) is a highly effective brain stimulation treatment for severe depression. Identifying neurochemical changes linked with ECT may point to biomarkers and predictors of successful response.We used proton magnetic resonance spectroscopy (1H-MRS) measure longitudinal in glutamate/glutamine (Glx), creatine (Cre), choline (Cho) N-acetylaspartate (NAA) the dorsal (dACC) subgenual anterior cingulate cortex (sgACC) bilateral hippocampus patients receiving scanned at...
RNA viruses continue to remain a threat for potential pandemics due their rapid evolution. Potentiating host antiviral pathways prevent or limit viral infections is promising strategy. Thus, by testing library of innate immune agonists targeting pathogen recognition receptors, we observe that Toll-like receptor 3 (TLR3), stimulator interferon genes (STING), TLR8, and Dectin-1 ligands inhibit arboviruses, Chikungunya virus (CHIKV), West Nile virus, Zika varying degrees. STING (cAIMP, diABZI,...
We analyzed brain MRI data from 372 young adult twins toidentify cortical regions in which gray matter thickness and volume are influenced by genetics. This was achieved using an A/C/E structural equation model that divides the variance of these traits, at each point on cortex, into additive genetic (A), shared (C), unique environmental (E) components. A strong influencewas found frontal parietal regions. Inaddition, we correlated with full-scale intelligence quotient for comparison maps,...
Structural and diffusion imaging studies demonstrate effects of age, sex, asymmetry in many brain structures. However, few have addressed how individual differences might influence the structural integrity superficial white matter (SWM), comprised short-range association (U-fibers), intracortical axons. This study thus applied a sophisticated computational analysis approach to data obtained from healthy individuals selected International Consortium for Brain Mapping (ICBM) database across...
Background Clinical brain MRI is normal in the majority of patients with anti- N -methyl-D-aspartate receptor (NMDAR) encephalitis. However, extensive deep white matter damage wasrecently identifiedin these using diffusion weighted imaging. Here, our aim was to study a particularly vulnerable compartment, late myelinating superficial matter. Methods Forty-six anti-NMDAR encephalitis were included. Ten out considered neurologically recovered (modified Rankin scale zero), while 36...
Electroconvulsive therapy (ECT) is arguably the most effective available treatment for severe depression. Recent studies have used MRI data to predict clinical outcome ECT and other antidepressant therapies. One challenge facing such selecting from among many metrics, which characterize complementary sometimes non-overlapping aspects of brain function connectomics. Here, we assessed ability aggregated, functional metrics basal activity connectivity response using machine learning.A radial...
Chronic wounds, including pressure ulcers, compromise the health of 6.5 million Americans and pose an annual estimated burden $25 billion to U.S. care system. When treating chronic clinicians must use meticulous documentation determine wound severity monitor healing progress over time. Yet, current practices using digital photography are often cumbersome labor intensive. The process transferring photos into Electronic Medical Records (EMRs) requires many steps can take several days. Newer...
White matter abnormalities have been shown in the large deep fibers of Alzheimer's disease patients. However, late myelinating superficial white comprised intracortical myelin and short-range association has not received much attention. To investigate this area, we extracted a surface corresponding to beneath cortex then applied cortical pattern-matching approach which allowed us register subsequently sample diffusivity along thousands points at interface between gray 44 patients with (Age:...
The risk of cognitive impairment is a concern for patients with major depressive disorder receiving electroconvulsive therapy (ECT). Here, we evaluate the acute, short-term and long-term effects ECT on tests processing speed, executive function, memory, attention.Forty-four (61% right unilateral, 39% mixed unilateral-bitemporal, left and/or bitemporal lead placement) underwent battery prior to (T1), after 2 sessions (T2), at end index (T3). Thirty-two returned 6-month follow-up (T4)....
Verbal and physical aggression begin early in life steadily decline thereafter normal development. As a result, elevated aggressive behavior adolescence may signal atypical development greater vulnerability for negative mental health outcomes. Converging evidence suggests that brain disturbances regions involved impulse control, emotional regulation, sensation seeking contribute to heightened aggression. However, little is known regarding the neural mechanisms underlying subtypes of (i.e.,...
Background The late myelinating superficial white matter at the juncture of cortical gray and comprising intracortical myelin short-range association fibers has not received attention in Huntington's disease. It is an area brain that sensitive to both normal aging neurodegenerative disease effects. Therefore, it may be processes. Methods Structural MRI data from 25 Pre-symptomatic subjects, 24 patients 49 healthy controls was run through a pattern-matching program. surface corresponding...
Abstract Electroconvulsive therapy (ECT) and ketamine treatment both induce rapidly acting antidepressant effects in patients with major depressive disorder unresponsive to standard treatments, yet their specific impact on emotion processing is unknown. Here, we examined the neural underpinnings of within across ( N = 44) receiving either ECT 17, mean age: 36.8, 11.0 SD ) or repeated subanesthetic (0.5 mg/kg) intravenous 27, 37.3, 10.8 using a naturalistic study design. MRI clinical data...
Abstract Background There is a growing population of children with in utero HIV exposure who are at risk poor neurodevelopmental outcomes despite avoiding infection. However, the underlying neurobiological pathways not understood and neuroimaging studies lacking. We aimed to investigate cortical brain structure HIV-exposed uninfected (HEU) compared HIV-unexposed (HU) examine relationship neurodevelopment. Methods The Drakenstein Child Health birth cohort study enrolled pregnant women from...
Despite accumulating evidence of structural deficits in individuals with psychopathy, especially frontal regions, our understanding systems-level disturbances cortical networks remains limited. We applied novel graph theory-based methods to assess information flow and connectivity based on thickness measures 55 psychopathy 47 normal controls. Compared controls, the group showed significantly altered interregional patterns. Furthermore, bilateral superior cortices network were identified as...
Aims Autonomic, cognitive, and neuropsychologic deficits appear in heart failure (HF) subjects, these compromised functions depend on cerebral cortex integrity addition to that of subcortical brainstem sites. Impaired autoregulation, low cardiac output, sleep-disordered-breathing, hypertension, diabetic conditions HF offer considerable potential affect cortical areas by loss neurons glia, which would be expressed as reduced thicknesses. However, except for gross descriptions volume...