A5000858271- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- Tryptophan and brain disorders
- Neural dynamics and brain function
- Cardiac Arrhythmias and Treatments
- Congenital Heart Disease Studies
- Cardiac pacing and defibrillation studies
- Electroconvulsive Therapy Studies
- Obstructive Sleep Apnea Research
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Morphological variations and asymmetry
- Medical Image Segmentation Techniques
- Neonatal and fetal brain pathology
- Atomic and Subatomic Physics Research
- Epilepsy research and treatment
- Neuroscience of respiration and sleep
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Music and Audio Processing
- stochastic dynamics and bifurcation
- Sleep and related disorders
- Lung Cancer Diagnosis and Treatment
Brain Mapping Foundation
2019-2024
University of California, Los Angeles
2018-2024
UCLA Health
2020-2021
Hertie Institute for Clinical Brain Research
2015-2018
Senckenberg Centre for Human Evolution and Palaeoenvironment
2015-2018
University of Tübingen
2015-2018
Bernstein Center for Computational Neuroscience Tübingen
2015
National Institute of Mental Health and Neurosciences
2012
Abstract Electroconvulsive therapy (ECT) and ketamine treatment both induce rapidly acting antidepressant effects in patients with major depressive disorder unresponsive to standard treatments, yet their specific impact on emotion processing is unknown. Here, we examined the neural underpinnings of within across ( N = 44) receiving either ECT 17, mean age: 36.8, 11.0 SD ) or repeated subanesthetic (0.5 mg/kg) intravenous 27, 37.3, 10.8 using a naturalistic study design. MRI clinical data...
Idiopathic/genetic generalized epilepsy (IGE/GGE) is characterized by seizures, which start and rapidly engage widely distributed networks, result in symptoms such as absences, myoclonic primary tonic-clonic seizures. Although routine magnetic resonance imaging apparently normal, many studies have reported structural alterations IGE/GGE patients using diffusion tensor voxel-based morphometry. Changes also been functional networks during spike wave discharges. However, network function the...
To assess the impact of colored noise on statistics in event-related functional MRI (fMRI) (visual stimulation using checkerboards) acquired by simultaneous multislice imaging enabling repetition times (TRs) between 2.64 to 0.26 s.T-values within visual cortex obtained with analysis tools that assume a first-order autoregressive plus white process (AR(1)+w) fixed AR coefficient versus higher-order models spatially varying coefficients were compared. In addition, dependency T-values...
The human brain is known to contain several functional networks that interact dynamically. Therefore, it desirable analyze the temporal features of these by dynamic connectivity (dFC). A sliding window approach was used in an event-related fMRI (visual stimulation using checkerboards) assess impact repetition time (TR) and size on BOLD dFC. In addition, we also examined spatial distribution dFC tested feasibility this for analysis interictal epileptiforme discharges. 15 healthy controls...
Abstract Subanesthetic ketamine is found to induce fast-acting and pronounced antidepressant effects, even in treatment resistant depression (TRD). However, it remains unclear how modulates neural function at the brain systems-level regulate emotion behavior. Here, we examined treatment-related changes inhibitory control network after single repeated therapy TRD. Forty-seven TRD patients (mean age = 38, 19 women) 32 healthy controls 35, 18 performed a functional magnetic resonance imaging...
Abstract Background Subanesthetic ketamine infusion therapy can produce fast-acting antidepressant effects in patients with major depression. How single and repeated treatment modulates the whole-brain functional connectome to affect clinical outcomes remains uncharacterized. Methods Data-driven whole brain connectivity (FC) analysis was used identify connections modified by depressive disorder (MDD). MDD ( N = 61, mean age 38, 19 women) completed baseline resting-state (RS) magnetic...
Patients with obstructive sleep apnea (OSA) show brain injury in sites responsible for autonomic, cognitive, and respiratory functions. Brain changes OSA may vary disease severity as assessed by the apnea-hypopnea index (AHI), which does not provide information about depth length contrast to oxygen desaturation. Although significant associations AHI are known OSA, it is unclear whether or extent of desaturations better correlate damage. We evaluated between changes, AHI, desaturation using...
Patients with major depressive disorder (MDD) exhibit impaired control of cognitive and emotional systems, including deficient response selection inhibition. Though these deficits are typically attributed to abnormal communication between macro-scale cortical networks, altered the cerebellum also plays an important role. Yet, how circuitry large-scale functional networks impact treatment outcome in MDD is not understood. We thus examined ketamine, which elicits rapid therapeutic effects MDD,...
Background Total sleep deprivation (TSD) transiently reverses depressive symptoms in a majority of patients with depression. How TSD modulates diffusion tensor imaging (DTI) measures white matter (WM) microstructure, which may be linked TSD’s rapid antidepressant effects, remains uncharacterized. Methods Patients depression ( N = 48, mean age 33, 26 women) completed diffusion-weighted and Hamilton Depression Rating (HDRS) rumination scales before after >24 h TSD. Healthy controls (HC)...
Genetic generalized epilepsies (GGEs) are characterized by spike-wave discharges (GSWDs) in electroencephalography (EEG) recordings without underlying structural brain lesions. The origin of the epileptic activity remains unclear, although several studies have reported involvement thalamus and default mode network (DMN). aim current study was to investigate networks involved generation temporal evolution GSWDs elucidate propagation activity.We examined 12 patients with GGE using...
Abstract Background Ketamine is a rapidly-acting antidepressant treatment with robust response rates. Previous studies have reported that serial ketamine therapy modulates resting state functional connectivity in several large-scale networks, though it remains unknown whether variations brain structure, function, and impact subsequent success. We used data-driven approach to determine pretreatment multimodal neuroimaging measures predict changes along symptom dimensions of depression...
Major depressive disorder (MDD) is associated with dysfunctional reward processing, which involves functional circuitry of the habenula (Hb) and nucleus accumbens (NAc). Since ketamine elicits rapid antidepressant antianhedonic effects in MDD, this study sought to investigate how serial infusion (SKI) treatment modulates static dynamic connectivity (FC) Hb NAc networks.
Adolescents with single ventricle heart disease (SVHD) exhibit mood and cognitive deficits, which may result from injury to the basal ganglia structures, including caudate nuclei. However, integrity of in SVHD adolescents is unclear. Our aim was examine global regional volumes, evaluate relationships between volumes scores healthy adolescents. We acquired two high-resolution T1-weighted images 23 37 controls using a 3.0-Tesla MRI scanner, as well assessed (Patient Health Questionnaire-9...
Obstructive sleep apnea (OSA) is accompanied by both gray and white matter differences in brain areas that regulate autonomic, cognitive, mood functions, which are deficient the condition. Such tissue changes have been examined through diffusion tensor kurtosis imaging-based procedures. However, poor in-plane spatial resolution of these techniques precludes precise determination extent injury. Tissue texture maps derived from ratio T1-weighted T2-weighted images can provide more adequate...
Abstract Dysfunctional reward processing in major depressive disorder (MDD) involves functional circuitry of the habenula (Hb) and nucleus accumbens (NAc). Ketamine elicits rapid antidepressant alleviates anhedonia MDD. To clarify how ketamine perturbs MDD, we examined serial infusions (SKI) modulate static dynamic connectivity (FC) Hb NAc networks. MDD participants (n=58, mean age=40.7 years, female=28) received four (0.5mg/kg) 2-3 times weekly. Resting-state fMRI scans clinical assessments...