A5001787883- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Functional Brain Connectivity Studies
- Music Therapy and Health
- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Heart Rate Variability and Autonomic Control
- Gut microbiota and health
- Advanced Neuroimaging Techniques and Applications
- Musculoskeletal pain and rehabilitation
- Pain Management and Placebo Effect
- Psychosomatic Disorders and Their Treatments
- Tryptophan and brain disorders
- Neuroscience and Music Perception
- Regulation of Appetite and Obesity
- Mindfulness and Compassion Interventions
- Advanced MRI Techniques and Applications
- Mental Health Research Topics
- Stress Responses and Cortisol
- Bariatric Surgery and Outcomes
- Nutrition and Health in Aging
- Gene expression and cancer classification
- Medicinal Plant Pharmacodynamics Research
- Whipple's Disease and Interleukins
- Neuroscience, Education and Cognitive Function
University of California, Los Angeles
2013-2018
Center for Neurologic Study
2014-2017
Pancreatic Cancer Action Network
2013-2015
Centre For Digestive Diseases
2013-2014
Alterations in gray matter (GM) density/volume and cortical thickness (CT) have been demonstrated small heterogeneous samples of subjects with differing chronic pain syndromes, including irritable bowel syndrome (IBS). Aggregating across 7 structural neuroimaging studies conducted at University California, Los Angeles, CA, USA, between August 2006 April 2011, we examined group differences regional GM volume 201 predominantly premenopausal female (82 IBS, mean age: 32±10 SD, 119 healthy...
Abnormal responses of the brain to delivered and expected aversive gut stimuli have been implicated in pathophysiology irritable bowel syndrome (IBS), a visceral pain occurring more commonly women. Task-free resting-state functional magnetic resonance imaging (fMRI) can provide information about dynamics activity that may be involved altered processing and/or modulation afferent signals. Fractional amplitude low-frequency fluctuation is measure power spectrum intensity spontaneous...
Resting-state functional magnetic resonance imaging has been used to investigate intrinsic brain connectivity in healthy subjects and patients with chronic pain. Sex-related differences the frequency power distribution within human insula (INS), a region involved integration of interoceptive, affective, cognitive influences, have reported. Here we aimed test sex disease-related alterations dorsal anterior INS. The INS is engaged during goal-directed tasks modulates default mode executive...
Background & Aims Regional reductions in gray matter (GM) have been reported several chronic somatic and visceral pain conditions, including irritable bowel syndrome (IBS) pancreatitis. Reported GM include insular anterior cingulate cortices, even though subregions are generally not specified. The majority of published studies suffer from limited sample size, heterogeneity populations, lack analyses for sex differences. We aimed to characterize regional changes cortical thickness (CT) a...
Studies have suggested chronic pain syndromes are associated with neural reorganization in specific regions perception, processing, and integration of pain. Urological pelvic syndrome (UCPPS) represents a collection characterized by pain, namely Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) Interstitial Cystitis/Painful Bladder (IC/PBS), that both poorly understood their pathophysiology, treated ineffectively. We hypothesized patients UCPPS may microstructural differences the...
Brain network activity associated with altered motor control in individuals chronic pain is not well understood. Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) a debilitating condition which previous studies have revealed resting pelvic floor muscle men CP/CPPS compared to healthy controls. We hypothesized that the brain networks controlling muscles would also show state function CP/CPPS. Here we describe results of first test this hypothesis focusing on cortical regions, termed...
Neuroimaging studies in obese subjects have identified abnormal activation of key regions central reward circuits, including the nucleus accumbens (NAcc), response to food-related stimuli. We aimed examine whether women with elevated body mass index (BMI) show structural and resting state (RS) functional connectivity alterations within network.Fifty healthy, premenopausal women, 19 overweight (high BMI=26-38 kg m(-2)) 31 lean (BMI=19-25 were selected from University California Los Angeles'...
In Brief Irritable bowel syndrome (IBS) is the most common chronic visceral pain disorder. The pathophysiology of IBS incompletely understood; however, evidence strongly suggests dysregulation brain–gut axis. aim this study was to apply multivariate pattern analysis identify an IBS-related morphometric brain signature that could serve as a central biological marker and provide new mechanistic insights into IBS. Parcellation 165 cortical subcortical regions performed using FreeSurfer...
Objective A growing body of preclinical and clinical literature suggests that brain-gut-microbiota interactions play an important role in human health disease, including hedonic food intake obesity. We performed a tripartite network analysis based on graph theory to test the hypothesis microbiota-derived fecal metabolites are associated with connectivity key regions brain's extended reward measures related Methods DTI resting state fMRI imaging was obtained from 63 healthy subjects without...
Regional cortical thickness alterations have been reported in many chronic inflammatory and painful conditions, including bowel diseases (IBD) irritable syndrome (IBS), even though the mechanisms underlying such neuroplastic changes remain poorly understood. In order to better understand contributing grey matter changes, current study sought identify differences regional between healthy controls two visceral pain syndromes, with without gut inflammation. 41 controls, 11 IBS subjects...
Background Early adverse life events (EALs) and sex have been identified as vulnerability factors for the development of several stress-sensitive disorders, including irritable bowel syndrome (IBS). We aimed to identify disease sex-based differences in resting state (RS) connectivity associated with EALs individuals IBS. Method A history before age 18 years was assessed using early trauma inventory. RS functional magnetic resonance imaging used patterns intrinsic brain oscillations form...
Abstract Background A majority of the subjects with irritable bowel syndrome ( IBS ) show increased behavioral and brain responses to expected delivered aversive visceral stimuli during controlled rectal balloon distension, palpation sigmoid colon. We aimed determine if altered cued uncued pain expectation are also seen in context a noxious somatic stimulus applied same dermatome as Methods task‐dependent functional magnetic resonance imaging technique was used investigate activity 37...
The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network is an ongoing multi-center collaborative research group established conduct integrated studies in participants with urologic chronic pelvic pain syndrome (UCPPS). goal these investigations provide new insights into etiology, natural history, clinical, demographic and behavioral characteristics, search for evaluate candidate biomarkers, systematically test contributions infectious agents symptoms,...
The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network has yielded neuroimaging and urinary biomarker findings that highlight unique alterations in brain structure proteins related tissue remodeling vascular patients with Urological Syndrome (UCPPS). We hypothesized localized changes diffusion tensor imaging (DTI) measurements might be associated corresponding protein levels UCPPS. To test this hypothesis, we created statistical parameter maps depicting...