A5046603443- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- Schizophrenia research and treatment
- Spatial Neglect and Hemispheric Dysfunction
- Functional Brain Connectivity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Tryptophan and brain disorders
- Genetic Associations and Epidemiology
- Mental Health and Psychiatry
- Stroke Rehabilitation and Recovery
- Technostress in Professional Settings
- Inflammation biomarkers and pathways
- COVID-19 and Mental Health
- Neuroscience and Music Perception
- Occupational Health and Burnout
- Diet and metabolism studies
- Psychological Well-being and Life Satisfaction
- Bioinformatics and Genomic Networks
- Psychosomatic Disorders and Their Treatments
- Neurological Disorders and Treatments
- Neural and Behavioral Psychology Studies
- Parkinson's Disease Mechanisms and Treatments
- Health and Well-being Studies
IMT School for Advanced Studies Lucca
2021-2024
Fondazione Santa Lucia
2010-2019
Istituti di Ricovero e Cura a Carattere Scientifico
2007-2019
Erasmus MC
2018
Framingham Heart Study
2018
Boston University
2018
Institute for Neurodegenerative Disorders
2018
The University of Texas Health Science Center at San Antonio
2018
University of Iowa
2007
Abstract Background There is no consensus about which hippocampal subfields become atrophic earliest in the course of Alzheimer's disease (AD). Methods Thirty AD patients, 41 mild cognitive impairment (MCI) and 38 healthy controls (HCs) underwent cerebral magnetic resonance imaging (with an automated segmentation protocol for volumetric analysis subfields) a test immediate delayed recall 15‐word list. Results The volumes presubiculum subiculum presented most remarkable reduction patient's...
White matter abnormalities have been shown in the large deep fibers of Alzheimer's disease patients. However, late myelinating superficial white comprised intracortical myelin and short-range association has not received much attention. To investigate this area, we extracted a surface corresponding to beneath cortex then applied cortical pattern-matching approach which allowed us register subsequently sample diffusivity along thousands points at interface between gray 44 patients with (Age:...
Anosognosia is a multidimensional phenomenon that negatively affects course of illness. This study aimed to explore the association between anosognosia and neuropsychiatric phenomena in mild Alzheimer's disease (AD) cognitive impairment (
Polyunsaturated fatty acids (PUFA) of the n-3 series have been linked to brain physiology and cognitive decline, but little is known about other components complex category. Here, we compared 30 molecular species pertaining saturated, monounsaturated, polyunsaturated, trans acids, measured in plasma by gas chromatography, 14 patients with a diagnosis amnestic single domain mild impairment (aMCI), Alzheimer's disease (AD), healthy controls (HC). As no participants showed neuroimaging evidence...
White matter hyperintensities (WMH) are brain areas of increased signal on T2-weighted or fluid attenuated inverse recovery magnetic resonance imaging (MRI) scans. In this study we present a new semi-automated method to measure WMH load that is based the segmentation intensity histogram fluid-attenuated inversion images. Thirty patients with Mild Cognitive Impairment variable were enrolled. The included: removal non-brain tissue, spatial normalization, cerebellum and stem, filtering,...
Insight has been mostly studied from a clinical perspective. Recently, attention moved to cognitive insight or the ability monitor and correct one's erroneous convictions. Here, we investigated neuroanatomical correlates of insight. We administered Beck scale 45 outpatients with schizophrenia diagnosis age- gender-matched healthy control subjects who underwent MRI investigation, including high-resolution volumetric diffusion tensor imaging sequences. Gray white matter volume, mean...
Dendritic cells (DCs) are major orchestrators of immune responses and inflammation. They migratory cells, which may play a role in Alzheimer's disease (AD), as suggested by prior vitro studies. With the intent to investigate clinical relevance DC modifications vivo, present study was aimed evaluate levels blood DCs AD patients, relation progression disease, severity its symptoms, treatment with acetylcholinesterase inhibitors (AChEIs), class drugs used improve cognitive functioning people...
Epidemiological data and etiopathogenesis of brain fog are very heterogeneous in the literature, preventing adequate diagnosis treatment. Our study aimed to explore relationship between fog, neuropsychiatric cognitive symptoms general population. A sample 441 subjects underwent a web-based survey, including PANAS, DASS-21, IES-R, Beck Cognitive Insight Scale, questionnaire investigating demographic information, subjective impairments (Scc) sleep disorders. ANOVA, ANCOVA, correlation multiple...
Characteristics associated with life expectancy in Alzheimer's disease (AD) are still far from known. Here we aimed at examining the ability of baseline/longitudinal clinical variables to predict time death. One-hundred fifty AD outpatients underwent diagnostic, neuropsychiatric, and functional assessment baseline (when ApoE ɛ4 was also investigated) each subsequent annual visit. A random effects joint modeling approach used simultaneously model longitudinal trajectory factor death,...
Abstract Lack of insight into illness is a multidimensional phenomenon that has relevant implications on clinical course and therapy compliance. Here, we focused metacognitive in schizophrenia, is, the ability to monitor one's changes state mind sensations, with aim investigating its neuroanatomical, psychopathological, neuropsychological correlates. Fifty‐seven consecutive patients Diagnostic Statistical Manual Mental Disorders (Fourth Edition, Text Revision) diagnosis schizophrenia were...
This study is one of the first aiming at investigating mental health in post-lockdown period an Italian adult population and detecting demographic psychological predictors for a worse outcome. 1401 participants answered web-based survey including Emotional Reaction Questionnaire (ERQ), Positive Affect Negative Scale (PANAS), Impact Event Scale-Revised (IES-R), General Health (GHQ), Depression, Anxiety Stress (DASS-21), Dutch Work Addiction (DUWAS). Simple slope analyses highlighted that...
The COVID-19 evolution has forced the massive introduction of homeworking (HW) for most employees in initial stages pandemic and then return to work, mainly due vaccination campaign. These multiple abrupt adjustment demands work may be a source intense stress office workers with consequences on wellbeing quality life. This long-term prospective study aimed at investigating effect adaptation broad population large Italian banking group job-related framework. We administered web-based survey...
In this study, we assess white matter microstructural deficit correlates of apathy level in 20 patients with amnestic mild cognitive impairment by means diffusion tensor imaging. Mean diffusivity correlated positively the right temporal portion uncinate, middle longitudinal and inferior fasciculi parathalamic matter, fornix posterior cingulum hemisphere. Fractional anisotropy results confirmed evidence disconnection associated all areas except fasciculus. These support view that alterations...