A5085902390- Biotin and Related Studies
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Viral Infectious Diseases and Gene Expression in Insects
- Food Quality and Safety Studies
- Microbial Metabolic Engineering and Bioproduction
- Ginseng Biological Effects and Applications
- Bacteriophages and microbial interactions
- Neurological and metabolic disorders
- Microbial Inactivation Methods
- Microbial Metabolites in Food Biotechnology
- Adipokines, Inflammation, and Metabolic Diseases
- Click Chemistry and Applications
- Bone health and osteoporosis research
- Iron Metabolism and Disorders
- Estrogen and related hormone effects
- Ginkgo biloba and Cashew Applications
- Asthma and respiratory diseases
- Immune cells in cancer
- Allergic Rhinitis and Sensitization
- Dialysis and Renal Disease Management
- Alcoholism and Thiamine Deficiency
- Nutrition, Health and Food Behavior
- Autophagy in Disease and Therapy
- S100 Proteins and Annexins
Catholic University of Daegu
2024
Korea University
2023
Kyungpook National University Hospital
2019-2022
Kyungpook National University
2020-2022
Konkuk University
2016
Catholic University of Korea
2013
Pohang University of Science and Technology
2009
Chronic inflammatory airway diseases including asthma are characterized by immune dysfunction to inhaled allergens. Our previous studies demonstrated that T cell priming allergens requires LPS, which is ubiquitously present in household dust In this study, we evaluated the role of vascular endothelial growth factor (VEGF) development and its polarization Th1 or Th17 cells when exposed LPS-contaminated An mouse model was induced sensitization with then challenged alone. Therapeutic...
The identification of HMGB1 as a late-mediator in sepsis has highlighted promising therapeutic target for treatment. Recent studies have revealed that annexin A5, 35 kDa Ca2+-dependent phospholipid binding protein, exerts anti-inflammatory effect by inhibiting LPS to TLR4/MD2 complex. Annexin A5 administration been shown protect against endotoxin lethality even when the treatment was given after early cytokine response, which prompted our group suspect may inhibit HMGB1, well TLR4. Here we...
Iron plays an important role in macrophage polarization by altering metabolic and redox status. However, the impact of iron on immune status macrophages is still controversial. In this study, we report that ferric ammonium citrate (FAC) upregulates PD-L1 expression macrophages. FAC not only altered phenotype but also led to enriching immune-modulatory T cell subsets. Since known be a constituent coenzymes facilitating processes mitochondria, examined FAC-overloaded measuring oxygen...
Recent studies have highlighted that early enhancement of the glycolytic pathway is a mode maintaining pro-inflammatory status immune cells. Thiamine, well-known co-activator pyruvate dehydrogenase complex, gatekeeping enzyme, shifts energy utilization glucose from glycolysis to oxidative phosphorylation. Thus, we hypothesized thiamine may modulate inflammation by alleviating metabolic during cell activation. First, using allithiamine, which showed most potent anti-inflammatory capacity...
Diabetes significantly impacts the immune system; however, its role in worsening sepsis prognosis remains poorly understood. This study investigated effect of hyperferritinemia on modulation septic diabetic patients. A cohort at Kyungpook National University Hospital stratified patients by diabetes status and followed them for 28 days. Additionally, CD4+ T cells from mice were analyzed proliferation, apoptosis, metabolic changes under ferritin treatment. Results clinical showed higher levels...
This study was conducted to investigate the physicochemical properties of mung bean starch and quality characteristics gels supplemented with gelatin isolated soy protein (0, 2, 5%) during storage at <TEX>$5^{\circ}C$</TEX> for 0, 24, 48, 72 hours. The swelling power did not significantly change, whereas those (ISP) increased. solubility ISP, however, increased increasing concentration. In addition, soluble amylose carbohydrate ISP decreased terms pasting measured by Rapid Visco Analyzer...
Abstract Kombucha is a healthy carbonated beverage made by fermenting tea extracts such as green and black through symbiotic culture of bacteria yeast. In this study, fermentation characteristics radical scavenging activity ginseng berry kombucha (GBK) Saccharomyces cerevisiae M-5 Gluconobacter oxydans were measured. As time increased, pH decreased titratable acidity increased. Reducing sugars rapidly on day 3. Alcohol content increased dramatically during period then decreased. GBK showed...
A new fixed-dose combination (FDC) formulation of raloxifene 60 mg and cholecalciferol 800 IU was developed to improve the medication compliance overall efficacy treatment in postmenopausal osteoporosis patients. The aim this study compare pharmacokinetics between two tablets FDC raloxifene/cholecalciferol products administered concomitantly at respective doses. This randomized, open-label, single-dose, two-treatment, two-way crossover included 46 volunteers. During each period, subjects...
Abstract How obesity affects immune function is not well understood. Clinically, strongly associated with severe T H 2 immunopathology 1-3 , though the physiological, cellular, and molecular underpinnings of this association remain obscure. Here, we demonstrate that obese mice are susceptible to atopic dermatitis (AD), a major manifestation disease burden in humans 4,5 . Mechanistically, show dysregulation nuclear hormone receptor (NHR) PPAR γ (peroxisome proliferator-activated gamma) cells...