Abstract Dentritic cell (DC)-based cancer immunotherapy faces challenges in both efficacy and practicality. However, DC-based vaccination requires multiple injections elaborates ex vivo manipulation, which substantially limits their use. Therefore, we sought to develop a chitosan nanoparticle (CH-NP)-based platform for the next generation of vaccines bypass manipulation induce immune responses via active delivery polyinosinic-polycytidylic acid sodium salt (poly I:C) target Toll-like...

Biofilm formation and microbial colonization on the surface of implant devices may cause dental caries peri-implantitis. Therefore, various treatments have been developed to improve antibacterial activity titanium implant.Silver-loaded polydopamine coating was formed by immersing pure in dopamine hydrochloride/HCl buffer solution for 24 h 50 mL silver nitrate solutions with different concentrations 30 min. Microbial growth inhibition curve analyses bacterial Streptococcus mutans...

Dental hygienists play a crucial role in patient communication, making communication competency an essential skill. This study aimed to develop and validate the Patient-Centered Communication Competency Scale (PCCS) for dental hygienists. Initial items were generated through literature review, expert content validity assessment, preliminary survey. An online survey was conducted with 400 working clinics hospitals. Construct examined using exploratory factor analysis (EFA) confirmatory (CFA),...

β-Agarase cleaves the β-1,4 linkages of agar to produce neoagarooligosaccharides (NAO), which are associated with various physiological functions. However, immunological functions NAO still unclear. In this study, we demonstrated that β-agarase DagA-produced neoagarohexaose (DP6), an product, promoted maturation dendritic cells (DCs) by Toll-like receptor 4 (TLR4). DP6 directly and indirectly enhanced activation natural killer (NK) in a TLR4-dependent manner vitro vivo. Finally, antitumor...

TiO₂ nanotubes (TNT) formation is beneficial for improving bone cell-material interaction and drug delivery Ti dental implants. Among the natural drugs to be installed in TNT, selected propolis has antibacterial anti-inflammatory properties. It a resinous product which collected by honeybees from various types of plants with their salivary enzymes. This study concludes that TNT loaded (PL-TNT-Ti) implant ability improve osseointegration. The particles were embedded within or adhered top. In...

Abstract Protein kinase 2 (CK2) activation was reported to enhance reactive oxygen species production and activate the nuclear factor κB (NF-κB) pathway. Because oxidative stress inflammation are critical events for tissue destruction during ischemia reperfusion (I/R), we sought determine whether CK2 important in renal response I/R. Mice underwent 25 min of were then reperfused. We confirmed an increased expression CK2α period, while CK2β remained consistent. administered...

The identification of HMGB1 as a late-mediator in sepsis has highlighted promising therapeutic target for treatment. Recent studies have revealed that annexin A5, 35 kDa Ca2+-dependent phospholipid binding protein, exerts anti-inflammatory effect by inhibiting LPS to TLR4/MD2 complex. Annexin A5 administration been shown protect against endotoxin lethality even when the treatment was given after early cytokine response, which prompted our group suspect may inhibit HMGB1, well TLR4. Here we...

Autism spectrum disorder (ASD) is heterogeneous neurodevelopmental disorders that primarily display social and communication impairments restricted/repetitive behaviors. ASD prevalence has increased in recent years, yet very limited therapeutic targets treatments are available to counteract the incapacitating disorder. Korean Red Ginseng (KRG) a popular herbal plant South Korea known for its wide range of effects nutritional benefits recently been gaining great scientific attention,...

This study investigated the effect of oral health education using a mobile app (OHEMA) on and swallowing-related quality life (SWAL-QoL) elderly population in community-based integrated care project (CICP). Forty individuals CICP were randomized into intervention control groups. OHEMA provided information customized management, exercises, intraoral extraoral massage methods for 50 min/session, once week, 6 weeks. Pre- post-intervention surveys assessed unstimulated salivary flow rate,...

The immunoregulatory cytokine Interleukin 10 (IL-10) protein is produced by various cells during the course of inflammatory disorders. Mainly, it downregulates pro-inflammatory cytokines, antigen presentation, and helper T cell activation. In this study, we show that ratio IL-10-producing was significantly increased in lineage negative (i.e., not T, B, or leukocyte lineages) than positive lymphoid peripheral tissues. We further observed innate (ILCs), here called firstly ILC10, were number...

The purpose of this study was to gather opinions from experts via the Delphi method inform future development a virtual reality based English language communication program for university level students in Korea. participants, who consisted panel and professors majored multimedia education, completed three surveys on Context, Input, Process, Product evaluation, which is referred as CIPP. In first survey, participants answered multiple choice questions open-ended related four areas relevant...

Abstract Background The Arthrobacter group is a known set of bacteria from cold regions, the species which are highly likely to play diverse roles at low temperatures. However, their survival mechanisms in regions such as Antarctica not yet fully understood. In this study, we compared genomes 16 strains within group, including strain PAMC25564, identify genomic features that help it survive environment. Results Using S rRNA sequence analysis, found and identified isolated cryoconite. We...

This study aimed to investigate the association between healthy lifestyle (HLS; i.e., diet quality, physical activity, normal weight) and periodontal diseases in Korean adults. Studying this may help inform future intervention programs at preventing development of diseases. Raw data Korea National Health Nutrition Examination Survey (KNHANES) VII (2016–2018) were used. Data from 12,689 adults aged 19 years over who had a examination analyzed. The associations HLS analyzed using multivariate...

In this study, green tea compounds (flavonoids, alkaloids, and phenolic acids) were analyzed in tea-containing dentifrices, their stability at different pH levels was evaluated. The separated under 0.01% phosphoric acid–acetonitrile gradient conditions detected by photodiode array detector 210, 280, 300, 335 nm. Column temperature set 20°C based on the results of screening various temperatures. Each compound showed good linearity optimized wavelength as well showing precision accuracy...

The aim of this study was to analyze the unreacted monomers four commonly used composite resins, which were released after curing with different polymerization conditions. Four consisting two hybrid types and flowable from manufacturers, photopolymerized using times distances. After polymerization, samples extracted for analysis at time points up 24 h. Released analyzed by reversed-phase liquid chromatography UV 210 nm. Longer shorter distances resulted in higher rates decreased release...

Objectives : In order to make a proposal of Korean standard dental hygiene curriculum, the job description National Health Personnel Licensing Examination Board was analyzed prepare analysis matrix hygienist select required core competency. Methods Data were test validity and categorize duties hygienist. A curriculum mapped out by making comparative courses necessary for American authorization existing proposals departments offered domestic three-year colleges four-year universities. Results...

Objectives : Prunus mume has been used for the folk medicine from old times. The purpose of study was to investigate antimicrobial activity prunus extract various oral microbes. Methods This carried out examine effect against Data were collected using a Dentocult SM Strip mutans and LB April 5 May 4, 2013. A total 36 experimental 32 control group selected this study. Results MIC tested 0.39% in S. mutans, salivarius auerus, 0.78% mitis, equi E. coli. In vivo, showed significantly lower...

Since very high temperature gas-cooled reactor (VHTR) components for a hydrogen production are designed lifetime of 30 to 60 years at high-temperature 950°C, material selection is important, and also one the most important properties in these metallic their longterm creep behavior. In this study, selecting suitable intermediate heat exchanger (IHX), hightemperature strengths several candidate alloys approved use by ASME VIII (boiler pressure vessel code) were reviewed. From review, alloy 617...

We found that resveratrol enhances interferon (IFN)-γ-induced tryptophanyl-tRNA-synthetase (TTS) expression in bone marrow- derived dendritic cells (BMDCs). Resveratrol-induced TTS is associated with glycogen synthase kinase-3β (GSK-3β) activity. In addition, we regulates naïve CD8+ T-cell polarization by modulating GSK-3β activity IFN-γ-stimulated BMDCs, and resveratol induces upregulation of T-cells the vivo tumor environment. Taken together, upregulates IFN-γ-induced a GSK-3β-dependent...

Objectives: The purpose of the study is to investigate and analyzed current status a dental hygiene curriculum according hygienist competency. Methods: subjects were 59 courses in department G University from April 1 May 30, 2015. Except for liberal arts, 51 finally selected relationship between For each course, systematic reviews made by subject name, core competency, achievement goals, lecture hours, weekly themes, learning goals. Three experts evaluated association competency Results:...

We report the use of poly(ε-caprolactone) (PCL) and poly-dopamine (PD) as a protective coating that inhibits corrosion underlying magnesium metal. The PD layer also improved adhesion PCL layer, which has been found to have significant effect on behavior. In this study, electrochemical methods were employed investigate behavior Mg after applying composite coatings. Potentiodynamic polarization measurements determined pretreated with effectively inhibited metal corrosion. addition, shown...