A5028792338- Mast cells and histamine
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Urticaria and Related Conditions
- Protein Kinase Regulation and GTPase Signaling
- Bone Metabolism and Diseases
- Histone Deacetylase Inhibitors Research
- Caveolin-1 and cellular processes
- Immune Cell Function and Interaction
- Natural product bioactivities and synthesis
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Receptor Mechanisms and Signaling
- Dermatology and Skin Diseases
- Cancer, Lipids, and Metabolism
- Immune Response and Inflammation
- Protein Degradation and Inhibitors
- Pharmacological Effects of Natural Compounds
- Rheumatoid Arthritis Research and Therapies
- NF-κB Signaling Pathways
- Bioactive Compounds and Antitumor Agents
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Sphingolipid Metabolism and Signaling
Konkuk University
2015-2024
Bridge University
2023
Konkuk University Medical Center
2008-2023
Jeju National University
2023
Cheju Halla General Hospital
2023
Korea National University of Transportation
2015
Government of the Republic of Korea
2015
Chungnam National University Hospital
2012
Sungkyunkwan University
1998-2008
Kyung Hee University
2008
A growing number of studies have demonstrated that physiological factors can influence the progression several cancers via cellular immune function, angiogenesis and metastasis. Recently, stress-induced catecholamines been shown to increase expression various cancer progressive factors, including vascular endothelial growth factor (VEGF), matrix metalloproteinases interleukins. However, a detailed mechanism remains be identified. In this study, we investigated role adrenergic receptors...
Sirtuins (SIRTs), NAD+-dependent class III histone deacetylases (HDACs), play an important role in the regulation of cell division, survival and senescence. Although a number effective SIRT inhibitors have been developed, little is known about specific mechanisms their anticancer activity. In this study, we investigated effects sirtinol, inhibitor, on MCF-7 human breast cancer cells. Apoptotic autophagic death were measured. Sirtinol significantly inhibited proliferation cells...
Receptor activator of NF-kB ligand (RANKL) generates intracellular reactive oxygen species (ROS), which increase RANKL-mediated signaling in osteoclast (OC) precursor bone marrow macrophages (BMMs). Here we show that a ROS scavenging protein DJ-1 negatively regulates RANKL-driven OC differentiation, also called osteoclastogenesis. ablation mice leads to decreased volume and an numbers. In vitro, the activation RANK-dependent signals is enhanced DJ-1-deficient BMMs as compared wild-type BMMs....
The rat mast cell line RBL-2H3 contains both phospholipase D (PLD)1 and PLD2. Previous studies with this indicated that expressed PLD1 PLD2 are strongly activated by stimulants of secretion. We now show use PLDs tagged enhanced green fluorescent protein PLD1, which is largely associated secretory granules, redistributes to the plasma membrane in stimulated cells processes reminiscent exocytosis fusion granules membrane. These secretion suppressed expression a catalytically inactive mutant or...
The discovery of new biomarkers for early detection drug-induced acute kidney injury (AKI) is clinically important. In this study, sensitive metabolomic identified in the urine rats were used to detect cisplatin-induced AKI. Cisplatin (10 mg kg(-1), i.p.) was administered Sprague-Dawley rats, which subsequently euthanized after 1, 3 or 5 days. cisplatin-treated mild histopathological alterations noted at day and these changes severe days 5. Blood urea nitrogen (BUN) serum creatinine (SCr)...
Deregulation of the epigenome component affects multiple pathways in cancer phenotype since acts at pinnacle hierarchy gene expression. Pioneering work over past decades has highlighted that targeting enzymes or proteins involved epigenetic regulation is a valuable approach to therapy. Very recent results demonstrated inhibiting reader BRD4 notable efficacy diverse types. We investigated potential as therapeutic target liver malignancy. was overexpressed three different large cohort...
Atopic dermatitis (AD) presents significant therapeutic challenges due to its poorly understood etiology. Eosinophilia, a hallmark of allergic inflammation, is implicated in AD pathogenesis. Interleukin-10 (IL-10)-producing regulatory B (Breg) cells exhibit potent anti-inflammatory effects. However, their role controlling AD-related eosinophilia not well understood. To investigate the impact eosinophils on AD, we employed IL-5Rα-deficient (Il5ra-/-) mice, which lack functional eosinophils....
CD19(+)CD5(+) regulatory B cells produce transforming growth factor β (TGF-β) in both mouse and human B-cell leukemias. In this study, TGF-β was uniquely produced by normal cells. TGF-β-producing (Br3) responses were characterized through allergic to cow's milk. total, 10 subjects milk 13 milk-tolerant selected following double-blinded, placebo-controlled food challenges. Their peripheral blood mononuclear stimulated vitro with casein. Following allergen stimulation, the percentage of Br3s...
Carnosic acid (CA) is a diterpene compound exhibiting antioxidative, anticancer, anti-angiogenic, anti-inflammatory, anti-metabolic disorder, and hepatoprotective neuroprotective activities. In this study, the effect of CA on various skin inflammatory responses its inhibitory mechanism were examined. strongly suppressed production IL-6, IL-8, MCP-1 from keratinocyte HaCaT cells stimulated with sodium lauryl sulfate (SLS) retinoic (RA). addition, blocked release nitric oxide (NO), tumor...
Trachelospermum jasminoides (Apocynaceae) has pharmacological effects that include anti-inflammatory, anti-bacterial and anti-viral activities, which have been observed from various studies. Of these effects, the anti-inflammatory capacity of compounds T. is not yet known exactly. In this study, we investigated compound can be used for suppression lipopolysacchaide (LPS) stimulated inflammatory responses in macrophages among five isolated compounds. β-sitosterol-β-D-glucoside (1) was found...
The sirtuins (SIRTs), a family of NAD + -dependent class III histone deacetylase, are involved in various biological processes including cell survival, division, senescence, and metabolism via activation the stress-response pathway.Recently, inhibition SIRTs has been considered promising anticancer strategy, but their precise mechanisms action not well understood.In particular, relevance p53 to SIRT-induced effects fully elucidated.We investigated novel SIRT inhibitor, MHY2256, its efficacy...
The molecular mechanism underlying the selective vulnerability of neurons to oxidative damage caused by ischemia—reperfusion (I/R) injury remains unknown. We sought determine role NADPH oxidase 1 (Nox1) in cerebral I/R-induced brain and survival newborn cells ischemic injured region. Male Wistar rats were subjected 90 min middle artery occlusion (MCAO) followed reperfusion. After reperfusion, infarction size, level superoxide 8-hydroxy-2′-deoxyguanosine (8-oxo-2dG), Nox1 immunoreactivity...
Abstract Objective Interleukin‐32 (IL‐32) is a recently discovered cytokine that appears to play critical role in human rheumatoid arthritis (RA). It highly expressed synovium and fibroblast‐like synoviocytes (FLS) from RA patients, but not patients with osteoarthritis (OA). This study was undertaken assess IL‐32 levels synovial fluid (SF) investigate the secretion regulation of FLS. Methods FLS SF were obtained joints patients. The expression activation signaling molecules examined by...
Foxp3 is a transcript factor for regulatory T cell development. Interestingly, Foxp3-expressing cells were identified in B cells, especially CD19(+)CD5(+) while those not examined CD19(+)CD5(-) cells. CD5(+) this study human PBMCs and found to consist of 8.5±3.5% CD19(+)CD5(+)Foxp3(+) showed spontaneous apoptosis. Rare Foxp3(+) (Breg) population was unveiled peripheral blood mononuclear suggested as possible (Treg). The immunologic the clinical relevant Breg needs be further investigated.