A5041269113- Cancer, Hypoxia, and Metabolism
- Reproductive System and Pregnancy
- Glycosylation and Glycoproteins Research
- Natural product bioactivities and synthesis
- ATP Synthase and ATPases Research
- Genomics, phytochemicals, and oxidative stress
- Endometriosis Research and Treatment
- Healthcare and Venom Research
- Autophagy in Disease and Therapy
- Immune cells in cancer
- Ginseng Biological Effects and Applications
- Immune Response and Inflammation
- Galectins and Cancer Biology
- NF-κB Signaling Pathways
- Traditional Chinese Medicine Studies
- Cell Adhesion Molecules Research
- Biochemical Acid Research Studies
- Gastrointestinal motility and disorders
- Cell death mechanisms and regulation
- Cancer Research and Treatments
- Plant-based Medicinal Research
- Estrogen and related hormone effects
- Advanced Glycation End Products research
- Inflammasome and immune disorders
- Pharmacological Effects of Natural Compounds
Pusan National University
2016-2025
Sungkyunkwan University
2008-2024
Gwangju Institute of Science and Technology
2024
Second Affiliated Hospital of Jilin University
2024
Gachon University Gil Medical Center
2024
Dunsan Korean Medicine Hospital
2019-2021
Kyung Hee University
2015
Dongguk University
2004-2007
Ministry of Science ICT and Future Planning
2004
Dongguk University WISE
2004
Nowadays, the exploration of zinc oxide nanoparticles (ZnO NPs) based products is booming in various directions bio-nanomedicine and other consumer products, but comprehensive toxicological impact posed by ZnO NPs still remains unclear. The present study systematically investigates correlates toxicity evaluation RAW 264.7 murine macrophages (in vitro) male ICR mice vivo) two different administration routes, i.e. g.i. i.p. at doses. vitro studies showed a slight rise intracellular reactive...
Abstract Endometriosis is a disease characterized by implants of endometrial tissue outside the uterine cavity and strongly associated with infertility. Focal adhesion to peritoneum an indication incipient endometriosis. In this study, we examined effect various cytokines that are known be involved in pathology endometriosis on cell adhesion. Among investigated cytokines, transforming growth factor-β1 (TGF-β1) increased cells mesothelium through induction α2-6 sialylation. The expression...
A natural compound C23 H32 O4 Cl, ascochlorin (ASC) isolated from an incomplete fungus, Ascochyta viciae has been known to have several biological activities as antibiotic, antifungal, anti-cancer, anti-hypolipidemic, and anti-hypertension agent. In this study, anti-inflammatory activity investigated in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells, since ASC not observed on the inflammatory events. The present study clearly shown that (1-50 μM) significantly suppressed...
Abstract The Warburg effect, wherein cancer cells prefer glycolysis rather than oxidative phosphorylation even under normoxic conditions, is a major characteristic of malignant tumors. Lactate dehydrogenase A (LDHA) the main enzyme regulating and thus, target for novel anti-cancer drug development. Through our ongoing screening inhibitors, we found that several selenobenzene compounds have inhibitory effects on LDHA activity. Among them, 1-(phenylseleno)-4-(trifluoromethyl) benzene (PSTMB)...
Vascular endothelial growth factor and its receptor (VEGF-VEGFR) system play a critical role in the regulation of angiogenesis lymphangiogenesis vertebrates. Each VEGF has specific receptors, which it activates by binding to extracellular domain and, thus, regulates angiogenic balance early embryonic adult stages. However, de-regulation VEGF-VEGFR implicates directly various diseases, particularly cancer. Moreover, tumor needs dedicated blood supply provide oxygen other essential nutrients....
Sirtuin 7 (SIRT7) plays an important role in tumor development, and has been characterized as a potent regulator of cellular stress. However, the effect SIRT7 on sorafenib acquired resistance remains unclear possible anti-tumor mechanism beyond this process HCC not clarified. We examined therapeutic potential determined whether it functions synergistically with to overcome chemoresistance.
The aim of this study was to investigate the underlying mechanisms responsible for anticancer effects lupeol on human non‑small cell lung cancer (NSCLC). MTT assay and Trypan blue exclusion were used evaluate viability. DAPI staining flow cytometric analysis detect apoptosis. Molecular docking western blot performed determine target lupeol. We found that suppressed proliferation colony formation NSCLC cells in a dose‑dependent manner. In addition, increased chromatin condensation,...
Resistance to anticancer therapeutics occurs in virtually every type of cancer and becomes a major difficulty treatment. Although 5-fluorouracil (5FU) is the first-line choice therapy for gastric cancer, its effectiveness limited owing drug resistance. Recently, altered metabolism, including Warburg effect, preference glycolysis rather than oxidative phosphorylation energy production, has been accepted as pivotal mechanism regulating resistance chemotherapy. Thus, we investigated detailed...
Osimertinib, a selective third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), effectively targets the EGFR T790M mutant in non-small cell lung cancer (NSCLC). However, newly identified C797S mutation confers resistance to osimertinib. In this study, we explored role of pyruvate dehydrogenase 1 (PDK1) osimertinib resistance. Patients exhibiting initially displayed elevated PDK1 expression. Osimertinib-resistant lines with were established using A549,...
The sirtuins (SIRTs), a family of NAD + -dependent class III histone deacetylase, are involved in various biological processes including cell survival, division, senescence, and metabolism via activation the stress-response pathway.Recently, inhibition SIRTs has been considered promising anticancer strategy, but their precise mechanisms action not well understood.In particular, relevance p53 to SIRT-induced effects fully elucidated.We investigated novel SIRT inhibitor, MHY2256, its efficacy...