A5091686187- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Water Treatment and Disinfection
- Bone and Dental Protein Studies
- Biochemical and Molecular Research
- Vitamin D Research Studies
- Bone Metabolism and Diseases
- Reproductive System and Pregnancy
- Pharmacological Effects of Medicinal Plants
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Parathyroid Disorders and Treatments
Pusan National University
2022-2024
Kyungpook National University
2013
Osimertinib, a selective third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), effectively targets the EGFR T790M mutant in non-small cell lung cancer (NSCLC). However, newly identified C797S mutation confers resistance to osimertinib. In this study, we explored role of pyruvate dehydrogenase 1 (PDK1) osimertinib resistance. Patients exhibiting initially displayed elevated PDK1 expression. Osimertinib-resistant lines with were established using A549,...
The transdifferentiation of vascular smooth muscle cells (VSMCs) into osteoblast-like has been implicated in the context calcification. We investigated roles vitamin D receptor (Vdr) and runt-related transcription factor 2 (Runx2) osteoblastic differentiation VSMCs response to D3 using vitro cultures vivo Vdr knockout (Vdr-/-) Runx2 carboxy-terminus truncated heterozygous (Runx2+/ΔC) mice. Treatment with active promoted matrix mineral deposition, increased expressions Vdr, Runx2, genes but...
Endometriosis is a gynecological disease prevalent in women of reproductive age, and it characterized by the ectopic presence growth eutopic endometrium. The pathophysiology diagnostic biomarkers endometriosis have not yet been comprehensively determined. To discover molecular markers pathways underlying pathogenesis endometriosis, we identified differentially expressed genes (DEGs) three Gene Expression Omnibus microarray datasets (GSE11691, GSE23339, GSE7305) performed gene set enrichment...
Frankincense, a resin derived from trees of the Boswellia genus, has been used as an incense and type herbal medicine for treating inflammatory diseases such arthritis, chronic bowel illness, asthma. While endometriosis is well-known gynecological illness caused by ectopic attachment development uterine tissue over menstrual cycle, impact frankincense on this poorly understood. The purpose study was to explore effects endometriosis.